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    ncapd2.S non-SMC condensin I complex subunit D2 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 398080, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ncapd2.S
    Official Full Name
    non-SMC condensin I complex subunit D2 S homeolog
    Primary source
    Xenbase:XB-GENE-5854852
    Locus tag
    XELAEV_18036724mg
    See related
    EnsemblRapid:ENSXLAG00005023197 AllianceGenome:Xenbase:XB-GENE-5854852
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    pEg7; capd2; cnap1; ncapd2
    Summary
    Predicted to act upstream of or within cell division and mitotic chromosome condensation. Predicted to be located in cytosol. Is expressed in genital system. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NCAPD2 (non-SMC condensin I complex subunit D2). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See ncapd2.S in Genome Data Viewer
    Location:
    chromosome: 7S
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7S NC_054384.1 (4886803..4914060)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7S NC_030737.1 (4906041..4933251)

    Chromosome 7S - NC_054384.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 384 S homeolog Neighboring gene inhibitor of growth family member 4 S homeolog Neighboring gene small nucleolar RNA U85 Neighboring gene small nucleolar RNA U85 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase S homeolog Neighboring gene intermediate filament family orphan 1 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. pEg7, a new Xenopus protein required for mitotic chromosome condensation in egg extracts. Cubizolles F, et al. J Cell Biol, 1998 Dec 14. PMID 9852142, Free PMC Article
    2. 13S condensin actively reconfigures DNA by introducing global positive writhe: implications for chromosome condensation. Kimura K, et al. Cell, 1999 Jul 23. PMID 10428035
    3. Phosphorylation and activation of 13S condensin by Cdc2 in vitro. Kimura K, et al. Science, 1998 Oct 16. PMID 9774278
    4. Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein. Hirano T, et al. Cell, 1997 May 16. PMID 9160743
    5. The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A. Takemoto A, et al. Nat Struct Mol Biol, 2009 Dec. PMID 19915589

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitotic chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    condensin complex subunit 1
    Names
    13S condensin XCAP-D2 subunit
    chromosome assembly protein XCAP-D2
    chromosome condensation-related SMC-associated protein 1
    chromosome-associated protein D2
    eg7
    non-SMC condensin I complex, subunit D2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001088371.1 → NP_001081840.1  condensin complex subunit 1

      See identical proteins and their annotated locations for NP_001081840.1

      Status: PROVISIONAL

      Source sequence(s)
      AF067969
      UniProtKB/Swiss-Prot
      Q9YGS5, Q9YHY6
      UniProtKB/TrEMBL
      B7ZSB4
      Related
      ENSXLAP00005070796.1, ENSXLAT00005072342.1
      Conserved Domains (5) summary
      COG5098
      Location:57 → 1221
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      pfam12717
      Location:1045 → 1210
      Cnd1; non-SMC mitotic condensation complex subunit 1
      pfam12922
      Location:73 → 236
      Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term
      pfam16000
      Location:1258 → 1354
      CARMIL_C; CARMIL C-terminus
      sd00044
      Location:1031 → 1060
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054384.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      4886803..4914060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041570421.1 → XP_041426355.1  condensin complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A1L8FDW9, A0A974H9I9, B7ZSB4
      Conserved Domains (3) summary
      COG5098
      Location:57 → 1216
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      sd00044
      Location:1026 → 1055
      HEAT; HEAT repeat [structural motif]
      pfam16000
      Location:1253 → 1348
      CARMIL_C; CARMIL C-terminus

    2. XM_041570424.1 → XP_041426358.1  condensin complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A8J1L9Z9, B7ZSB4
      Conserved Domains (2) summary
      COG5098
      Location:118 → 1174
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      sd00044
      Location:984 → 1013
      HEAT; HEAT repeat [structural motif]

    3. XM_041570423.1 → XP_041426357.1  condensin complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A8J1L9Z9, B7ZSB4
      Related
      ENSXLAP00005070681.1, ENSXLAT00005072225.1
      Conserved Domains (2) summary
      COG5098
      Location:118 → 1174
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      sd00044
      Location:984 → 1013
      HEAT; HEAT repeat [structural motif]

    4. XM_041570422.1 → XP_041426356.1  condensin complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A1L8FDW9, A0A974H9I9, B7ZSB4
      Related
      ENSXLAP00005070230.1, ENSXLAT00005071768.1
      Conserved Domains (3) summary
      COG5098
      Location:57 → 1216
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      sd00044
      Location:1026 → 1055
      HEAT; HEAT repeat [structural motif]
      pfam16000
      Location:1253 → 1348
      CARMIL_C; CARMIL C-terminus

    5. XM_041570425.1 → XP_041426359.1  condensin complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A8J1L9Z9, B7ZSB4
      Conserved Domains (2) summary
      COG5098
      Location:118 → 1174
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      sd00044
      Location:984 → 1013
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9YHY6.1 GenPept UniProtKB/Swiss-Prot:Q9YHY6

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