col18a1.L collagen type XVIII alpha 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: col18a1.L
Official Full Name: collagen type XVIII alpha 1 L homeolog
Primary source: Xenbase:XB-GENE-941374
Locus tag: XELAEV_18044797mg
See related: EnsemblRapid:ENSXLAG00005026277 AllianceGenome:Xenbase:XB-GENE-941374
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: kno; kno1; col18a1; col18sv-a
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and extracellular matrix organization. Predicted to be located in collagen-containing extracellular matrix and extracellular space. Predicted to be part of collagen trimer. Is expressed in anatomical system; mesenchyme; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in primary angle-closure glaucoma. Orthologous to human COL18A1 (collagen type XVIII alpha 1 chain). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (81655859..81761491)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (71156459..71262388)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: collagen type XVIII alpha 1 L homeolog

Names: type XVIII collagen long; type XVIII collagen middle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087652.1 → NP_001081121.1 collagen type XVIII alpha 1 L homeolog precursor

See identical proteins and their annotated locations for NP_001081121.1

Status: PROVISIONAL

Source sequence(s)

AY052763

UniProtKB/TrEMBL

A0A974BUW7, Q8JFF7

Related

ENSXLAP00005079267.1, ENSXLAT00005080858.1

Conserved Domains (3) summary

pfam01391
Location:623 → 681

Collagen; Collagen triple helix repeat (20 copies)

cd00247
Location:1130 → 1300

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...

cl22861
Location:31 → 219

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...