SLC35B4 solute carrier family 35 member B4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC35B4provided by HGNC
Official Full Name: solute carrier family 35 member B4provided by HGNC
Primary source: HGNC:HGNC:20584
See related: Ensembl:ENSG00000205060 MIM:610923; AllianceGenome:HGNC:20584
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: YEA; YEA4
Summary: Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]
Expression: Ubiquitous expression in placenta (RPKM 6.0), brain (RPKM 5.9) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q33

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (134289332..134320338, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (135597448..135628436, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (133974084..134001682, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel YAP1/SLC35B4 axis promotes gastric cancer (GC) development and progression, and this axis could be a potential candidate for prognosis and therapeutics in GC.
Title: A novel YAP1/SLC35B4 regulatory axis contributes to proliferation and progression of gastric carcinoma.
SLC35B4 single nucleotide polymorphism rs1646724 was associated with recurrence in patients with localized disease and survival in patients with advanced prostate cancer.
Title: A common regulatory variant in SLC35B4 influences the recurrence and survival of prostate cancer.
Our data showed that knock-out of the SLC35B4 gene does not affect major UDP-Xyl- and UDP-GlcNAc-dependent glycosylation pathways.
Title: Lysine at position 329 within a C-terminal dilysine motif is crucial for the ER localization of human SLC35B4.
Glucose levels activate SLC35B4 expression. This triggers a downstream effect via Hsp60 and other proteins. We hypothesize that the downstream effect on the proteins is mediated via altering the glycosylation pattern inside liver cells
Title: SLC35B4, an Inhibitor of Gluconeogenesis, Responds to Glucose Stimulation and Downregulates Hsp60 among Other Proteins in HepG2 Liver Cell Lines.
subcellular localization of SLC35B4
Title: Subcellular localization of UDP-GlcNAc, UDP-Gal and SLC35B4 transporters.
Decreased SLC35B4 expression led to increased gluconeogenesis in HepG2 cells.
Title: Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis.
Transport capabilities for UDP-Glc and UDP-Xyl were determined with Golgi vesicles isolated from transformed cells
Title: The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH47519 (e-PCR)
- UniSTS:61242

AB060201 (e-PCR)
- UniSTS:479805

RH47952 (e-PCR)
- UniSTS:24406

SGC32924 (e-PCR)
- UniSTS:53724

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables UDP-N-acetylglucosamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-N-acetylglucosamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-N-acetylglucosamine transmembrane transporter activity	TAS Traceable Author Statement more info
enables UDP-xylose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-xylose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-xylose transmembrane transporter activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP-N-acetylglucosamine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in UDP-xylose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gluconeogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nucleotide sugar transporter SLC35B4

Names: UDP-Xylose/N-Acetylglucosamine transporter; UDP-xylose and UDP-N-acetylglucosamine transporter; YEA4 homolog; solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032826.5 → NP_116215.1 nucleotide sugar transporter SLC35B4

See identical proteins and their annotated locations for NP_116215.1

Status: VALIDATED

Source sequence(s)

AB052892, AC008154

Consensus CDS

CCDS34756.1

UniProtKB/Swiss-Prot

A4D1P3, A6NNS4, Q53GQ7, Q8TCU7, Q969S0, Q96K33

Related

ENSP00000367770.4, ENST00000378509.9

Conserved Domains (1) summary

pfam08449
Location:2 → 314

UAA; UAA transporter family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

134289332..134320338 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011516645.4 → XP_011514947.1 nucleotide sugar transporter SLC35B4 isoform X1

Conserved Domains (2) summary

pfam08449
Location:28 → 314

UAA; UAA transporter family

cl23754
Location:87 → 310

EamA; EamA-like transporter family
XM_047420996.1 → XP_047276952.1 nucleotide sugar transporter SLC35B4 isoform X2