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    Plcd1 phospholipase C, delta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24655, updated on 27-Nov-2024

    Summary

    Official Symbol
    Plcd1provided by RGD
    Official Full Name
    phospholipase C, delta 1provided by RGD
    Primary source
    RGD:3346
    See related
    EnsemblRapid:ENSRNOG00000032238 AllianceGenome:RGD:3346
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Plc1
    Summary
    Enables several functions, including inositol 1,4,5 trisphosphate binding activity; phospholipid binding activity; and phosphoric ester hydrolase activity. Involved in several processes, including positive regulation of inositol trisphosphate biosynthetic process; positive regulation of norepinephrine secretion; and response to prostaglandin F. Located in mitochondrial membrane. Used to study congestive heart failure and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Orthologous to human PLCD1 (phospholipase C delta 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 103.2), Muscle (RPKM 72.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Plcd1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (127672955..127695939, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (118795196..118818186, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (127753514..127782070, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene CTD small phosphatase like Neighboring gene microRNA 26a Neighboring gene villin-like Neighboring gene uncharacterized LOC102548352 Neighboring gene DLEC1 cilia and flagella associated protein Neighboring gene acetyl-Coenzyme A acyltransferase 1B Neighboring gene solute carrier family 22, member 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activating protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activating protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables calcium-dependent phospholipid binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables inositol 1,4,5 trisphosphate binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphatidic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylserine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within labyrinthine layer blood vessel development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of inositol trisphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of norepinephrine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to aluminum ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hyperoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to peptide hormone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to prostaglandin F IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
    Names
    PLC-III
    PLC-delta-1
    Phospholipase C-delta1
    phosphoinositide phospholipase C
    phosphoinositide phospholipase C-delta-1
    phospholipase C delta 1 long form
    phospholipase C-III
    NP_058731.2
    XP_006244125.1
    XP_038936754.1
    XP_038936755.1
    XP_038936756.1
    XP_038936757.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017035.2NP_058731.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P10688, Q80WI4, Q9QVD3, Q9QVD4, Q9QVD5
      UniProtKB/TrEMBL
      A6I3V0, G3V9D1
      Conserved Domains (4) summary
      cd00275
      Location:628755
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08593
      Location:295596
      PI-PLCc_delta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta
      cd13363
      Location:22139
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      cd16217
      Location:144283
      EFh_PI-PLCdelta1; EF-hand motif found in phosphoinositide phospholipase C delta 1 (PI-PLC-delta1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      127672955..127695939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244063.5XP_006244125.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y0I7, A6Y857
      Related
      ENSRNOP00000076591.1, ENSRNOT00000113471.2
      Conserved Domains (7) summary
      cd00275
      Location:628782
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08593
      Location:295596
      PI-PLCc_delta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta
      PLN02952
      Location:213778
      PLN02952; phosphoinositide phospholipase C
      cd13363
      Location:22139
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam00169
      Location:30130
      PH; PH domain
      pfam09279
      Location:213295
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam14788
      Location:159208
      EF-hand_10; EF hand
    2. XM_039080826.2XP_038936754.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X2

      UniProtKB/Swiss-Prot
      P10688, Q80WI4, Q9QVD3, Q9QVD4, Q9QVD5
      UniProtKB/TrEMBL
      A0A8I6GIK0
      Related
      ENSRNOP00000090035.1, ENSRNOT00000110954.2
      Conserved Domains (4) summary
      cd00275
      Location:654781
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08593
      Location:321622
      PI-PLCc_delta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta
      cd13363
      Location:48165
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      cd16217
      Location:170309
      EFh_PI-PLCdelta1; EF-hand motif found in phosphoinositide phospholipase C delta 1 (PI-PLC-delta1)
    3. XM_039080828.1XP_038936756.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X4

      Conserved Domains (3) summary
      cd00275
      Location:372499
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08593
      Location:39340
      PI-PLCc_delta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta
      pfam09279
      Location:832
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    4. XM_039080829.2XP_038936757.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X5

      Conserved Domains (3) summary
      cd13363
      Location:22139
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      cd16217
      Location:144283
      EFh_PI-PLCdelta1; EF-hand motif found in phosphoinositide phospholipase C delta 1 (PI-PLC-delta1)
      cl14615
      Location:295430
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    5. XM_039080827.2XP_038936755.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X3

      Conserved Domains (3) summary
      cd13363
      Location:48165
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      cd16217
      Location:170309
      EFh_PI-PLCdelta1; EF-hand motif found in phosphoinositide phospholipase C delta 1 (PI-PLC-delta1)
      cl14615
      Location:321456
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily