Grk6 G protein-coupled receptor kinase 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grk6provided by RGD
Official Full Name: G protein-coupled receptor kinase 6provided by RGD
Primary source: RGD:61986
See related: EnsemblRapid:ENSRNOG00000014615 AllianceGenome:RGD:61986
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gprk6
Summary: Enables G protein-coupled receptor kinase activity. Involved in several processes, including cellular response to lipopolysaccharide; desensitization of G protein-coupled receptor signaling pathway; and negative regulation of anion channel activity. Predicted to be located in membrane. Predicted to be active in cytoplasm. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GRK6 (G protein-coupled receptor kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 344.0), Spleen (RPKM 326.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (9182160..9198380, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (9177018..9192813, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (9705917..9721921, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of GRK6 alleviates chronic visceral hypersensitivity through downregulation of P2Y6 receptors in anterior cingulate cortex of rats with prenatal maternal stress.
Title: Overexpression of GRK6 alleviates chronic visceral hypersensitivity through downregulation of P2Y6 receptors in anterior cingulate cortex of rats with prenatal maternal stress.
Downregulation of GRK6 in arcuate nucleus promotes chronic visceral hypersensitivity via NF-kappaB upregulation in adult rats with neonatal maternal deprivation.
Title: Downregulation of GRK6 in arcuate nucleus promotes chronic visceral hypersensitivity via NF-κB upregulation in adult rats with neonatal maternal deprivation.
Study shows that secreted miR-27a induced by cyclic stretch modulates the proliferation of endothelial cells in hypertension via g-protein-coupled receptor kinase 6.
Title: Secreted miR-27a Induced by Cyclic Stretch Modulates the Proliferation of Endothelial Cells in Hypertension via GRK6.
GRK6 might be a key molecular involved in peripheral mechanism of neuropathic pain and that overexpression of GRK6 might be a potential strategy for treatment for neuropathic pain through inhibition of CXCR2 signal pathway.
Title: Overexpression of GRK6 attenuates neuropathic pain via suppression of CXCR2 in rat dorsal root ganglion.
The ratio of GRK6/ARRB2 in DSP model rats was significantly higher than that in controls.
Title: G protein-coupled receptor kinase 6/β-arrestin 2 system in a rat model of dopamine supersensitivity psychosis.
Up-regulation in GRK6 protein expression after LPS stimulation.
Title: Expression of G-protein-coupled receptor kinase 6 (GRK6) after acute spinal cord injury in adult rat.
decreased expression of GRK6 in the spinal cord in the neuropathic pain model. Low GRK6 level per se is not sufficient to induce a decrease in pain threshold except in the presence of an inflammatory stimulus.
Title: Decreased expression and role of GRK6 in spinal cord of rats after chronic constriction injury.
GRK-6 is involved in the mechanism by which estrogen/oocytes augments follicle-stimulating hormone action in granulosa cells.
Title: GRK-6 mediates FSH action synergistically enhanced by estrogen and the oocyte in rat granulosa cells.
Tianqi Pingchan Granule can increase the expression of GRK6, inhibit the increase of abnormal involuntary movement, and reduce the incidence of levodopa-induced dyskinesia in rats with Parkinson disease.
Title: [Effects of Chinese herbal medicine Tianqi Pingchan Granule on G protein-coupled receptor kinase 6 involved in the prevention of levodopa-induced dyskinesia in rats with Parkinson disease].
endogenous GRK6 mediate homologous beta-AR desensitization in myometrial cells.
Title: Endogenous G protein-coupled receptor kinase 6 triggers homologous beta-adrenergic receptor desensitization in primary uterine smooth muscle cells.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor kinase activity	IEA Inferred from Electronic Annotation more info
enables beta-adrenergic receptor kinase activity	IEA Inferred from Electronic Annotation more info
enables beta-adrenergic receptor kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in desensitization of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in desensitization of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of anion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G protein-coupled receptor kinase 6

Names: g protein-coupled receptor kinase GRK6

NP_001106183.1

EC 2.7.11.16

NP_001106184.1

EC 2.7.11.16

NP_113845.2

EC 2.7.11.16

XP_038951961.1

EC 2.7.11.16

XP_063132786.1

EC 2.7.11.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001112712.2 → NP_001106183.1 G protein-coupled receptor kinase 6 isoform c

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

P97548

Related

ENSRNOP00000073781.2, ENSRNOT00000079063.3

Conserved Domains (2) summary

cd05630
Location:185 → 469

STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6

cl02565
Location:35 → 179

RGS; Regulator of G protein signaling (RGS) domain superfamily
NM_001112713.1 → NP_001106184.1 G protein-coupled receptor kinase 6 isoform b

Status: VALIDATED

Source sequence(s)

AF040750, EX488847

UniProtKB/TrEMBL

F1LNP2, Q792R1

Related

ENSRNOP00000050134.4, ENSRNOT00000047958.6

Conserved Domains (3) summary

smart00220
Location:186 → 448

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05630
Location:185 → 469

STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6

cl02565
Location:35 → 179

RGS; Regulator of G protein signaling (RGS) domain superfamily
NM_031657.4 → NP_113845.2 G protein-coupled receptor kinase 6 isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

P97549

Related

ENSRNOP00000101572.1, ENSRNOT00000171946.1

Conserved Domains (3) summary

smart00220
Location:186 → 448

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05630
Location:185 → 469

STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6

cl02565
Location:35 → 179

RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

9182160..9198380 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276716.1 → XP_063132786.1 G protein-coupled receptor kinase 6 isoform X1
XM_039096033.2 → XP_038951961.1 G protein-coupled receptor kinase 6 isoform X2

Conserved Domains (1) summary

cl21453
Location:1 → 204

PKc_like; Protein Kinases, catalytic domain