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    Tshr thyroid stimulating hormone receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25360, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tshrprovided by RGD
    Official Full Name
    thyroid stimulating hormone receptorprovided by RGD
    Primary source
    RGD:3911
    See related
    EnsemblRapid:ENSRNOG00000003972 AllianceGenome:RGD:3911
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TSHRA
    Summary
    Enables thyroid-stimulating hormone receptor activity. Involved in positive regulation of cell population proliferation. Predicted to be located in basolateral plasma membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); cardiomyopathy; hyperthyroidism (multiple); and mitral valve prolapse. Orthologous to human TSHR (thyroid stimulating hormone receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 17.6), Lung (RPKM 14.5) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Tshr in Genome Data Viewer
    Location:
    6q31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (116072321..116206009)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (110341585..110475297)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (115170290..115306871)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479243 Neighboring gene centrosomal protein 128 Neighboring gene small nucleolar RNA SNORA79 Neighboring gene general transcription factor 2A subunit 1 Neighboring gene uncharacterized LOC134479244 Neighboring gene stonin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables thyroid-stimulating hormone receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thyroid-stimulating hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables thyroid-stimulating hormone receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables thyroid-stimulating hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thyroid-stimulating hormone receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell surface receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to glycoprotein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glycoprotein ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to thyrotropin-releasing hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to thyrotropin-releasing hormone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cochlea morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dopaminergic neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within inner ear receptor cell development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inner ear receptor cell stereocilium organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of locomotion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thyroid-stimulating hormone signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thyroid-stimulating hormone signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thyroid-stimulating hormone signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    thyrotropin receptor
    Names
    TSH-R

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012888.2NP_037020.2  thyrotropin receptor precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P21463
      UniProtKB/TrEMBL
      A6JEC7, G3V6J1
      Related
      ENSRNOP00000005671.2, ENSRNOT00000005671.6
      Conserved Domains (3) summary
      sd00033
      Location:5477
      LRR_RI; leucine-rich repeat [structural motif]
      cd15964
      Location:415689
      7tmA_TSH-R; thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors
      pfam13306
      Location:65221
      LRR_5; Leucine rich repeats (6 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      116072321..116206009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111802.2XP_038967730.2  thyrotropin receptor isoform X1