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    Cyp4a12b cytochrome P450, family 4, subfamily a, polypeptide 12B [ Mus musculus (house mouse) ]

    Gene ID: 13118, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cyp4a12bprovided by MGI
    Official Full Name
    cytochrome P450, family 4, subfamily a, polypeptide 12Bprovided by MGI
    Primary source
    MGI:MGI:3611747
    See related
    Ensembl:ENSMUSG00000078597 AllianceGenome:MGI:3611747
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cyp4a12
    Summary
    Enables arachidonate omega-hydroxylase activity. Involved in omega-hydroxylase P450 pathway. Predicted to be located in apical plasma membrane; endoplasmic reticulum membrane; and extracellular space. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in liver; metanephros; nervous system; nose; and respiratory system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to several human genes including CYP4A22 (cytochrome P450 family 4 subfamily A member 22). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E18 (RPKM 10.9), genital fat pad adult (RPKM 3.6) and 3 other tissues See more
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    Genomic context

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    See Cyp4a12b in Genome Data Viewer
    Location:
    4 D1; 4 52.99 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115268821..115296231)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115411624..115439034)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 12a Neighboring gene predicted gene, 52675 Neighboring gene STARR-seq mESC enhancer starr_11114 Neighboring gene STARR-seq mESC enhancer starr_11115 Neighboring gene cytochrome P450, family 4, subfamily a, member 30, pseudogene Neighboring gene STARR-seq mESC enhancer starr_11117 Neighboring gene STARR-seq mESC enhancer starr_11118 Neighboring gene STARR-seq mESC enhancer starr_11119 Neighboring gene predicted gene 12837 Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 30b Neighboring gene predicted gene 12833

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta. Le Bouquin R, et al. Fundam Clin Pharmacol, 2004 Apr. PMID 15066132
    2. Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver. Jeffery B, et al. Arch Biochem Biophys, 2004 Sep 15. PMID 15313227
    3. A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans. Heng YM, et al. Biochem J, 1997 Aug 1. PMID 9271096, Free PMC Article
    4. Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation. Muller DN, et al. Biochem J, 2007 Apr 1. PMID 17112342, Free PMC Article
    5. Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs. Bell DR, et al. Biochem J, 1993 Aug 15. PMID 8363569, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 16-hydroxypalmitate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alkane 1-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkane 1-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arachidonate omega-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fatty acid omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene-B4 20-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables medium-chain fatty acid omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arachidonate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in icosanoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in kidney development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lauric acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lauric acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in linoleic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in omega-hydroxylase P450 pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4A12B
    Names
    cytochrome P450, family 4, subfamily a family
    cytochrome P450, family 4, subfamily a, polypeptide 12
    NP_758510.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172306.2 → NP_758510.2  cytochrome P450 4A12B precursor

      Status: VALIDATED

      Source sequence(s)
      AK098123, BB665127, BC060945
      Consensus CDS
      CCDS18490.1
      UniProtKB/Swiss-Prot
      A2A974
      UniProtKB/TrEMBL
      B0G0Y1
      Related
      ENSMUSP00000092487.4, ENSMUST00000094887.4
      Conserved Domains (1) summary
      cd20678
      Location:70 → 503
      CYP4B-like; cytochrome P450 family 4, subfamily B and similar cytochrome P450s, including subfamilies A, T, X, and Z

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      115268821..115296231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_007821.2: Suppressed sequence

      Description
      NM_007821.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A974.1 GenPept UniProtKB/Swiss-Prot:A2A974

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