Mapk3 mitogen-activated protein kinase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mapk3provided by MGI
Official Full Name: mitogen-activated protein kinase 3provided by MGI
Primary source: MGI:MGI:1346859
See related: Ensembl:ENSMUSG00000063065 AllianceGenome:MGI:1346859
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p44; Erk1; Ert2; Mnk1; Erk-1; Esrk1; Prkm3; Mtap2k; p44erk1; p44mapk
Summary: Enables MAP kinase activity and phosphotyrosine residue binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; nervous system development; and regulation of DNA-binding transcription factor activity. Acts upstream of or within several processes, including Bergmann glial cell differentiation; ERK1 and ERK2 cascade; and respiratory system development. Located in cytosol; nucleus; and pseudopodium. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Parkinson's disease; carcinoma (multiple); and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in colon adult (RPKM 245.8), large intestine adult (RPKM 217.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.25 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (126358798..126364988)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (126759626..126765816)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SP1 regulates BMSC osteogenic differentiation through the miR-133a-3p/MAPK3 axis : SP1 regulates osteogenic differentiation of BMSCs.
Title: SP1 regulates BMSC osteogenic differentiation through the miR-133a-3p/MAPK3 axis : SP1 regulates osteogenic differentiation of BMSCs.
Taurine promotes insulin synthesis by enhancing Isl-1 expression through miR-7a/RAF1/ERK1/2 pathway.
Title: Taurine promotes insulin synthesis by enhancing Isl-1 expression through miR-7a/RAF1/ERK1/2 pathway.
BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis.
Title: BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis.
Insulin-Like Growth Factor1 Preserves Gastric Pacemaker Cells and Motor Function in Aging via ERK1/2 Activation.
Title: Insulin-Like Growth Factor1 Preserves Gastric Pacemaker Cells and Motor Function in Aging via ERK1/2 Activation.
G Protein-Dependent Activation of the PKA-Erk1/2 Pathway by the Striatal Dopamine D1/D3 Receptor Heteromer Involves Beta-Arrestin and the Tyrosine Phosphatase Shp-2.
Title: G Protein-Dependent Activation of the PKA-Erk1/2 Pathway by the Striatal Dopamine D1/D3 Receptor Heteromer Involves Beta-Arrestin and the Tyrosine Phosphatase Shp-2.
ERK1/2-dependent TSPO overactivation associates with the loss of mitophagy and mitochondrial respiration in ALS.
Title: ERK1/2-dependent TSPO overactivation associates with the loss of mitophagy and mitochondrial respiration in ALS.
Proteomic characterization of spinal cord synaptoneurosomes from Tg-SOD1/G93A mice supports a role for MNK1 and local translation in the early stages of amyotrophic lateral sclerosis.
Title: Proteomic characterization of spinal cord synaptoneurosomes from Tg-SOD1/G93A mice supports a role for MNK1 and local translation in the early stages of amyotrophic lateral sclerosis.
Mechanisms of ERK phosphorylation triggered via mouse formyl peptide receptor 2.
Title: Mechanisms of ERK phosphorylation triggered via mouse formyl peptide receptor 2.
ERK1 loss accelerates the progression of osteoarthritis in aged mice via NRF2/BACH1 signaling.
Title: ERK1 loss accelerates the progression of osteoarthritis in aged mice via NRF2/BACH1 signaling.
Role of MAPK ERK1/2 and p38 in the Regulation of Secretory Functions of Different Populations of Neuroglia in Ethanol-Induced Neurodegeneration.
Title: Role of MAPK ERK1/2 and p38 in the Regulation of Secretory Functions of Different Populations of Neuroglia in Ethanol-Induced Neurodegeneration.

Submit: New GeneRIF Correction See all GeneRIFs (537)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (4) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mapk3 (e-PCR), detects polymorphism
- UniSTS:469817

Prkm3-rs1 (e-PCR), detects polymorphism
- UniSTS:144262

Mapk3 (e-PCR), detects polymorphism
- UniSTS:507052

Mapk3 (e-PCR), detects polymorphism
- UniSTS:143826

Mapk3 (e-PCR), detects polymorphism
- UniSTS:143827

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables MAP kinase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Bergmann glial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ERBB2-ERBB3 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in Schwann cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac neural crest cell development involved in heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage development	IDA Inferred from Direct Assay more info	PubMed
involved_in caveolin-mediated endocytosis	TAS Traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in cellular response to toxic substance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to tumor necrosis factor	IGI Inferred from Genetic Interaction more info	PubMed
involved_in decidualization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within face development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in interleukin-1-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lung morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apolipoprotein binding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within outer ear morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of macrophage proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere capping	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of xenophagy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Golgi inheritance	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of cellular pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in regulation of early endosome to late endosome transport	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of ossification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of stress-activated MAPK cascade	TAS Traceable Author Statement more info	PubMed
involved_in response to epidermal growth factor	ISO Inferred from Sequence Orthology more info
involved_in response to epidermal growth factor	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to exogenous dsRNA	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction in response to DNA damage	IEA Inferred from Electronic Annotation more info
involved_in signal transduction in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thymus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within thyroid gland development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within trachea formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of xenophagy	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	TAS Traceable Author Statement more info	PubMed
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info
located_in caveola	TAS Traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in early endosome	TAS Traceable Author Statement more info	PubMed
located_in focal adhesion	TAS Traceable Author Statement more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in late endosome	TAS Traceable Author Statement more info	PubMed
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in pseudopodium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mitogen-activated protein kinase 3

Names: MAP kinase 3; extracellular signal-regulated kinase 1; insulin-stimulated MAP2 kinase; microtubule-associated protein 2 kinase; p44 MAP kinase; pp42/MAP kinase

NP_036082.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011952.2 → NP_036082.1 mitogen-activated protein kinase 3

See identical proteins and their annotated locations for NP_036082.1

Status: VALIDATED

Source sequence(s)

BC029712, BQ929318

Consensus CDS

CCDS21841.1

UniProtKB/Swiss-Prot

Q61531, Q63844, Q8K0X5, Q91YW5

UniProtKB/TrEMBL

A0A0U1RPX4

Related

ENSMUSP00000051619.10, ENSMUST00000057669.16

Conserved Domains (1) summary

cd07849
Location:37 → 371

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases