REL REL proto-oncogene, NF-kB subunit [Gallus gallus (chicken)] - Gene

Summary

Symbol: RELprovided by CGNC
Full Name: REL proto-oncogene, NF-kB subunitprovided by CGNC
Primary source: CGNC:5934
See related: Ensembl:ENSGALG00010019036
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: p68-c-rel
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	3	NC_052534.1 (2114854..2148940)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	3	NC_052575.1 (2081519..2115667)

Chromosome 3 - NC_052534.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alterations between v-Rel and c-Rel locate within the Rel homology region (RHR) of the family that might confer functional differences.
Title: Discreet mutations from c-Rel to v-Rel alter kappaB DNA recognition, IkappaBalpha binding, and dimerization: implications for v-Rel oncogenicity.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to stress	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to cytokine	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: proto-oncogene c-Rel

Names: C-Rel protein; C-Rel proto-oncogene protein; p68; v-rel avian reticuloendotheliosis viral oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167726.2 → NP_001161198.2 proto-oncogene c-Rel

Status: VALIDATED

Source sequence(s)

JAENSK010000059

UniProtKB/Swiss-Prot

P16236

UniProtKB/TrEMBL

F1P3A5

Related

ENSGALP00010027485.1, ENSGALT00010046110.1

Conserved Domains (2) summary

cd07933
Location:7 → 178

RHD-n_c-Rel; N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel

cd01177
Location:185 → 280

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...