SEMA7A semaphorin 7A [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: SEMA7Aprovided by CGNC
Official Full Name: semaphorin 7Aprovided by CGNC
Primary source: CGNC:969
See related: Ensembl:ENSGALG00010021187
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 10

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	10	NC_052541.1 (2548353..2582471)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	10	NC_052582.1 (2421710..2455834)

Chromosome 10 - NC_052541.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sema3D expression is limited to neural crest cells migrating out of the midbrain/hindbrain regions, while Sema7A expression is widespread in both cranial and trunk neural crest cells
Title: Sema3D and Sema7A have distinct expression patterns in chick embryonic development.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables chemorepellent activity	IEA Inferred from Electronic Annotation more info	PubMed
enables integrin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables semaphorin receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of axon extension involved in axon guidance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neural crest cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of axon extension	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of macrophage cytokine production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in semaphorin-plexin signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: semaphorin-7A

Names: sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A; semaphorin 7A (John Milton Hagen blood group); semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199749.2 → NP_001186678.1 semaphorin-7A precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000245

UniProtKB/TrEMBL

A0A8V0ZPB2, F1NIZ9

Related

ENSGALP00010030540.1, ENSGALT00010051349.1

Conserved Domains (3) summary

cd11243
Location:47 → 461

Sema_7A; The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108)

smart00423
Location:463 → 511

PSI; domain found in Plexins, Semaphorins and Integrins

cl11960
Location:524 → 599

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

2548353..2582471

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046898954.1 → XP_046754910.1 semaphorin-7A isoform X8
XM_046898956.1 → XP_046754912.1 semaphorin-7A isoform X8
XM_046898958.1 → XP_046754914.1 semaphorin-7A isoform X8
XM_046898959.1 → XP_046754915.1 semaphorin-7A isoform X8
XM_046898960.1 → XP_046754916.1 semaphorin-7A isoform X8
XM_046898961.1 → XP_046754917.1 semaphorin-7A isoform X8
XM_046898955.1 → XP_046754911.1 semaphorin-7A isoform X8
XM_046898952.1 → XP_046754908.1 semaphorin-7A isoform X2

UniProtKB/TrEMBL

A0A8V0ZPB2
XM_046898953.1 → XP_046754909.1 semaphorin-7A isoform X4

UniProtKB/TrEMBL

A0A8V0ZPB2

Related

ENSGALP00010030543.1, ENSGALT00010051352.1
XM_040706249.2 → XP_040562183.1 semaphorin-7A isoform X6

UniProtKB/TrEMBL

A0A8V0ZPB2

Conserved Domains (3) summary

cd11243
Location:46 → 460

Sema_7A; The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108)

smart00423
Location:462 → 510

PSI; domain found in Plexins, Semaphorins and Integrins

cl11960
Location:536 → 588

Ig; Immunoglobulin domain
XM_040706244.2 → XP_040562178.1 semaphorin-7A isoform X1

UniProtKB/TrEMBL

A0A8V0ZPB2

Conserved Domains (3) summary

cd11243
Location:133 → 547

Sema_7A; The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108)

smart00423
Location:549 → 587

PSI; domain found in Plexins, Semaphorins and Integrins

cl11960
Location:623 → 675

Ig; Immunoglobulin domain
XM_040706248.2 → XP_040562182.1 semaphorin-7A isoform X5

UniProtKB/TrEMBL

A0A8V0ZPB2

Conserved Domains (3) summary

cd11243
Location:81 → 495

Sema_7A; The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108)

smart00423
Location:497 → 535

PSI; domain found in Plexins, Semaphorins and Integrins

cl11960
Location:571 → 623

Ig; Immunoglobulin domain
XM_040706246.2 → XP_040562180.1 semaphorin-7A isoform X3

UniProtKB/TrEMBL

A0A8V0ZPB2

Conserved Domains (3) summary

cd11243
Location:101 → 515

Sema_7A; The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108)

smart00423
Location:517 → 555

PSI; domain found in Plexins, Semaphorins and Integrins

cl11960
Location:591 → 643

Ig; Immunoglobulin domain
XM_046898963.1 → XP_046754919.1 semaphorin-7A isoform X8
XM_040706250.2 → XP_040562184.1 semaphorin-7A isoform X8

Conserved Domains (4) summary

cd11243
Location:1 → 393

Sema_7A; The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108)

smart00423
Location:395 → 443

PSI; domain found in Plexins, Semaphorins and Integrins

cd00096
Location:478 → 484

Ig; Ig strand C [structural motif]

cl11960
Location:454 → 527

Ig; Immunoglobulin domain
XM_046898962.1 → XP_046754918.1 semaphorin-7A isoform X8
XM_015278806.4 → XP_015134292.1 semaphorin-7A isoform X8

Conserved Domains (4) summary

cd11243
Location:1 → 393

Sema_7A; The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108)

smart00423
Location:395 → 443

PSI; domain found in Plexins, Semaphorins and Integrins

cd00096
Location:478 → 484

Ig; Ig strand C [structural motif]

cl11960
Location:454 → 527

Ig; Immunoglobulin domain
XM_015278803.4 → XP_015134289.1 semaphorin-7A isoform X7

UniProtKB/TrEMBL

A0A8V0ZB91, A0A8V0ZPB2

Related

ENSGALP00010030537.1, ENSGALT00010051346.1