U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Adra2b adrenergic receptor, alpha 2b [ Mus musculus (house mouse) ]

    Gene ID: 11552, updated on 27-Nov-2024

    Summary

    Official Symbol
    Adra2bprovided by MGI
    Official Full Name
    adrenergic receptor, alpha 2bprovided by MGI
    Primary source
    MGI:MGI:87935
    See related
    Ensembl:ENSMUSG00000058620 AllianceGenome:MGI:87935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    [a]2B; a2b-AR; Adra-2b; alpha2B; alpha2-C2
    Summary
    Enables alpha2-adrenergic receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway; MAPK cascade; and angiogenesis. Predicted to be located in cell surface; cytosol; and intracellular membrane-bounded organelle. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; central nervous system; liver; and retina. Human ortholog(s) of this gene implicated in diabetic neuropathy; hypertension; myocardial infarction; obesity; and type 2 diabetes mellitus. Orthologous to human ADRA2B (adrenoceptor alpha 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adra2b in Genome Data Viewer
    Location:
    2 F1; 2 61.95 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (127205099..127209141)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127363179..127367221)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:127163035-127163218 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:127163294-127163403 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:127163407-127163608 Neighboring gene STARR-positive B cell enhancer ABC_E8793 Neighboring gene dual specificity phosphatase 2 Neighboring gene astacin like metalloendopeptidase Neighboring gene STARR-seq mESC enhancer starr_05625 Neighboring gene predicted gene, 39923 Neighboring gene STARR-seq mESC enhancer starr_05626 Neighboring gene glycerol-3-phosphate acyltransferase 2, mitochondrial

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adrenergic receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables alpha2-adrenergic receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alpha2-adrenergic receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables alpha2-adrenergic receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables epinephrine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables epinephrine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables epinephrine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adrenergic receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female pregnancy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of uterine smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of uterine smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor transactivation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of vascular associated smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of vascular associated smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    alpha-2B adrenergic receptor
    Names
    alpha-2B adrenoceptor
    alpha-2B adrenoreceptor
    alpha-2BAR
    subtype alpha2-C2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009633.4NP_033763.3  alpha-2B adrenergic receptor

      Status: VALIDATED

      Source sequence(s)
      AL731836
      Consensus CDS
      CCDS16701.2
      UniProtKB/TrEMBL
      Q925K6, Q925K7
      Related
      ENSMUSP00000100539.2, ENSMUST00000104934.2
      Conserved Domains (2) summary
      PRK12323
      Location:209354
      PRK12323; DNA polymerase III subunits gamma and tau; Provisional
      cd15321
      Location:7435
      7tmA_alpha2B_AR; alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      127205099..127209141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)