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    spidey spidey [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31703, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spideyprovided by FlyBase
    Official Full Name
    spideyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029975
    Locus tag
    Dmel_CG1444
    See related
    AllianceGenome:FB:FBgn0029975
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1444; Dmel\CG1444; Kar; KAR; KAR[CG1444]
    Summary
    Predicted to enable very-long-chain 3-oxoacyl-CoA reductase activity. Involved in cellular response to nutrient levels; negative regulation of cell growth; and positive regulation of lipid storage. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; head epidermis primordium; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to several human genes including HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spidey in Genome Data Viewer
    Location:
    7C2-7C2; 1-21 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7908931..7911885)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7802964..7805918)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene by S6 Neighboring gene defective proboscis extension response 14 Neighboring gene snazarus Neighboring gene hold'em

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood. Storelli G, et al. Dev Cell, 2019 Jan 28. PMID 30554999, Free PMC Article
    2. Drosophila melanogaster Acetyl-CoA-carboxylase sustains a fatty acid-dependent remote signal to waterproof the respiratory system. Parvy JP, et al. PLoS Genet, 2012. PMID 22956916, Free PMC Article
    3. Drosophila Spidey/Kar Regulates Oenocyte Growth via PI3-Kinase Signaling. Cinnamon E, et al. PLoS Genet, 2016 Aug. PMID 27500738, Free PMC Article
    4. Steroid Hormone Signaling Is Essential for Pheromone Production and Oenocyte Survival. Chiang YN, et al. PLoS Genet, 2016 Jun. PMID 27333054, Free PMC Article
    5. BEAF regulates cell-cycle genes through the controlled deposition of H3K9 methylation marks into its conserved dual-core binding sites. Emberly E, et al. PLoS Biol, 2008 Dec 23. PMID 19108610, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables very-long-chain 3-oxoacyl-CoA reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to nutrient levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    spidey
    Names
    CG1444-PA
    spidey-PA
    NP_572420.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7908931..7911885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132192.3 → NP_572420.1  spidey [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572420.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3N1
      Related
      FBpp0071047
      Conserved Domains (2) summary
      PLN02780
      Location:8 → 321
      PLN02780; ketoreductase/ oxidoreductase
      cd05356
      Location:52 → 288
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3N1 Q9W3N1

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