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    CG17760 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36385, updated on 9-Dec-2024

    Summary

    Official Symbol
    CG17760provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033756
    Locus tag
    Dmel_CG17760
    See related
    AllianceGenome:FB:FBgn0033756
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD21019; Dmel\CG17760; Galphaq; GNAQ/11/14
    Summary
    Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and phospholipase C-activating dopamine receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in labellum. Human ortholog(s) of this gene implicated in Sturge-Weber syndrome; autosomal dominant hypocalcemia 2; congestive heart failure; familial hypocalciuric hypercalcemia 2; and familial multiple nevi flammei. Orthologous to human GNA11 (G protein subunit alpha 11) and GNAQ (G protein subunit alpha q). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See CG17760 in Genome Data Viewer
    Location:
    49B9-49B10; 2-67 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12625808..12628619)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8513313..8516124)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene G protein alpha subunit q Neighboring gene uncharacterized protein Neighboring gene muskelin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding  
    enables G protein-coupled receptor binding  
    enables G-protein beta/gamma-subunit complex binding  
    enables G-protein beta/gamma-subunit complex binding  
    enables GTPase activity  
    enables GTPase activity  
    enables guanyl nucleotide binding  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    part_of heterotrimeric G-protein complex  

    General protein information

    Preferred Names
    uncharacterized protein
    Names
    CG17760-PB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12625808..12628619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043074.2 → NP_001036539.1  uncharacterized protein Dmel_CG17760 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036539.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQV5
      Conserved Domains (2) summary
      cd00066
      Location:34 → 347
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:13 → 351
      G_alpha; G protein alpha subunit
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