SELENOP2 selenoprotein P2 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: SELENOP2provided by CGNC
Official Full Name: selenoprotein P2provided by CGNC
Primary source: CGNC:52226
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: SELPB; SEPP2; SEPP1L
Summary: This gene has 5-exon structure similar to chicken selenoprotein P1 gene (GeneID:431587). These two genes are thought to have arisen by whole genome duplication. This gene encodes a vertebrate-specific selenoprotein that contains a single selenocysteine (Sec) residue compared to 13 Sec residues in chicken selenoprotein P. The exact function of this selenoprotein is not known; however, it is predicted to have a signal peptide, so it is probably secreted like selenoprotein P, and may function as an extracellular antioxidant. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains a single SECIS element. [provided by RefSeq, Feb 2018]
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Genomic context

Location:: chromosome: 8

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	8	NC_052539.1 (20715680..20718064, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	8	NC_052580.1 (20724785..20727169, complement)

Chromosome 8 - NC_052539.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

At super-nutritional Se, most selenoproteins were upregulated in chicken kidney, but Sepp2 and Sep15 was only upregulated in Se excess (5.0 mg/kg) bird.
Title: Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables selenium binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in selenium compound metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: selenoprotein Pb

Names: selenoprotein P 2; selenoprotein P, plasma, 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001348769.2 → NP_001335698.1 selenoprotein Pb precursor

Status: REVIEWED

Source sequence(s)

JAENSK010000239

Conserved Domains (1) summary

pfam04592
Location:23 → 238

SelP_N; Selenoprotein P, N terminal region

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

20715680..20718064 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

20724785..20727169 complement

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GenBank, FASTA, Sequence Viewer (Graphics)