TXNRD3 thioredoxin reductase 3 [Gallus gallus (chicken)] - Gene

Summary

Symbol: TXNRD3provided by CGNC
Full Name: thioredoxin reductase 3provided by CGNC
Primary source: CGNC:4647
See related: Ensembl:ENSGALG00010021129
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Summary: The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals and some vertebrates. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2017]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	12	NC_052543.1 (10561077..10580831)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	12	NC_052584.1 (10589044..10608787)

Chromosome 12 - NC_052543.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dietary low Se downregulated the mRNA expressions of Gpx1-4, Txnrd3, Sepn1, Selw, Sepx1, Selh, and SEPSECS.
Title: Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info	PubMed
enables glutathione-disulfide reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info	PubMed
enables thioredoxin-disulfide reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info	PubMed
involved_in glutathione metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: thioredoxin reductase 3

NP_001116249.1

EC 1.8.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122777.3 → NP_001116249.1 thioredoxin reductase 3

Status: REVIEWED

Source sequence(s)

JAENSK010000252

UniProtKB/TrEMBL

A0A8V0ZNY0

Related

ENSGALP00010030414.1, ENSGALT00010051223.1

Conserved Domains (5) summary

cd03419
Location:27 → 108

GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

TIGR01438
Location:118 → 606

TGR; thioredoxin and glutathione reductase selenoprotein

pfam00070
Location:299 → 375

Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase

pfam02852
Location:478 → 588

Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

cl21454
Location:116 → 164

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins