Grin2d glutamate receptor, ionotropic, NMDA2D (epsilon 4) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grin2dprovided by MGI
Official Full Name: glutamate receptor, ionotropic, NMDA2D (epsilon 4)provided by MGI
Primary source: MGI:MGI:95823
See related: Ensembl:ENSMUSG00000002771 AllianceGenome:MGI:95823
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NR2D; GluN2D; NMDAR2D
Summary: Enables NMDA glutamate receptor activity. Involved in regulation of synaptic plasticity. Acts upstream of or within adult locomotory behavior; regulation of sensory perception of pain; and startle response. Located in synapse. Is expressed in brain. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 46. Orthologous to human GRIN2D (glutamate ionotropic receptor NMDA type subunit 2D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 12.8), CNS E18 (RPKM 5.9) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.54 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (45481307..45520708, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45831883..45871194, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential expression of GluN2 NMDA receptor subunits in the dorsal horn of male and female rats.
Title: Differential expression of GluN2 NMDA receptor subunits in the dorsal horn of male and female rats.
Understanding the role of the NMDA receptor subunit, GluN2D, in mediating NMDA receptor antagonist-induced behavioral disruptions in male and female mice.
Title: Understanding the role of the NMDA receptor subunit, GluN2D, in mediating NMDA receptor antagonist-induced behavioral disruptions in male and female mice.
Potential Roles for the GluN2D NMDA Receptor Subunit in Schizophrenia.
Title: Potential Roles for the GluN2D NMDA Receptor Subunit in Schizophrenia.
GluN2D Subunit in Parvalbumin Interneurons Regulates Prefrontal Cortex Feedforward Inhibitory Circuit and Molecular Networks Relevant to Schizophrenia.
Title: GluN2D Subunit in Parvalbumin Interneurons Regulates Prefrontal Cortex Feedforward Inhibitory Circuit and Molecular Networks Relevant to Schizophrenia.
GluN2D subunit-containing NMDA receptors regulate reticular thalamic neuron function and seizure susceptibility.
Title: GluN2D subunit-containing NMDA receptors regulate reticular thalamic neuron function and seizure susceptibility.
GluN2D expression is regulated by restraint stress and supports active stress coping bouts.
Title: GluN2D expression is regulated by restraint stress and supports active stress coping bouts.
Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice.
Title: Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice.
Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model.
Title: Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model.
NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice.
Title: NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice.
High Salt Intake Recruits Tonic Activation of NR2D Subunit-Containing Extrasynaptic NMDARs in Vasopressin Neurons.
Title: High Salt Intake Recruits Tonic Activation of NR2D Subunit-Containing Extrasynaptic NMDARs in Vasopressin Neurons.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Grin2d (e-PCR), detects polymorphism
- UniSTS:531451

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NMDA glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables NMDA glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables NMDA glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NMDA glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables glutamate binding	IEA Inferred from Electronic Annotation more info
enables glutamate binding	ISO Inferred from Sequence Orthology more info
enables glutamate-gated calcium ion channel activity	ISO Inferred from Sequence Orthology more info
enables glutamate-gated calcium ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables glutamate-gated receptor activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane import into cytosol	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane import into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cellular response to L-glutamate	IEA Inferred from Electronic Annotation more info
involved_in cellular response to L-glutamate	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ionotropic glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal synaptic plasticity	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within startle response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NMDA selective glutamate receptor complex	ISO Inferred from Sequence Orthology more info
part_of NMDA selective glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in hippocampal mossy fiber to CA3 synapse	IEA Inferred from Electronic Annotation more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	NAS Non-traceable Author Statement more info	PubMed
located_in presynaptic active zone membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutamate receptor ionotropic, NMDA 2D

Names: GluRepsilon4; N-methyl D-aspartate receptor subtype 2D; glur epsilon 4; glutamate [NMDA] receptor subunit epsilon-4; ionotropic NMDA glutamate receptor epsilon 4 subunit type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008172.3 → NP_032198.2 glutamate receptor ionotropic, NMDA 2D precursor

See identical proteins and their annotated locations for NP_032198.2

Status: VALIDATED

Source sequence(s)

AC149053

Consensus CDS

CCDS21267.1

UniProtKB/Swiss-Prot

C9K0Z5, Q03391

UniProtKB/TrEMBL

C9K0Z4

Related

ENSMUSP00000147663.2, ENSMUST00000211713.2

Conserved Domains (2) summary

cd13718
Location:427 → 827

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:48 → 410

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

45481307..45520708 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152692.1 → XP_036008585.1 glutamate receptor ionotropic, NMDA 2D isoform X9

UniProtKB/TrEMBL

C9K0Z4

Conserved Domains (2) summary

cd13718
Location:408 → 825

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cl10011
Location:156 → 402

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_006540631.5 → XP_006540694.3 glutamate receptor ionotropic, NMDA 2D isoform X7

UniProtKB/TrEMBL

C9K0Z4

Conserved Domains (2) summary

cd13718
Location:432 → 832

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cl10011
Location:156 → 415

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_036152691.1 → XP_036008584.1 glutamate receptor ionotropic, NMDA 2D isoform X5

UniProtKB/TrEMBL

C9K0Z4

Conserved Domains (2) summary

cd13718
Location:432 → 843

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cl10011
Location:156 → 415

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_011250804.4 → XP_011249106.3 glutamate receptor ionotropic, NMDA 2D isoform X6

UniProtKB/TrEMBL

C9K0Z4

Conserved Domains (2) summary

cd13718
Location:432 → 838

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cl10011
Location:156 → 415

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_036152690.1 → XP_036008583.1 glutamate receptor ionotropic, NMDA 2D isoform X4

UniProtKB/TrEMBL

C9K0Z4

Conserved Domains (2) summary

cd13718
Location:432 → 849

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cl10011
Location:156 → 415

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_036152688.1 → XP_036008581.1 glutamate receptor ionotropic, NMDA 2D isoform X2

UniProtKB/TrEMBL

C9K0Z4

Conserved Domains (3) summary

PHA03247
Location:1239 → 1335

PHA03247; large tegument protein UL36; Provisional

cd13718
Location:432 → 849

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cl10011
Location:156 → 415

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_036152687.1 → XP_036008580.1 glutamate receptor ionotropic, NMDA 2D isoform X1

UniProtKB/TrEMBL

C9K0Z4

Conserved Domains (2) summary

cd13718
Location:432 → 849

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cl10011
Location:156 → 415

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_011250802.3 → XP_011249104.1 glutamate receptor ionotropic, NMDA 2D isoform X3

See identical proteins and their annotated locations for XP_011249104.1

UniProtKB/TrEMBL

C9K0Z4

Conserved Domains (2) summary

cd13718
Location:427 → 844

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:48 → 410

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
XM_030242150.2 → XP_030098010.1 glutamate receptor ionotropic, NMDA 2D isoform X3

UniProtKB/TrEMBL

C9K0Z4

Conserved Domains (2) summary

cd13718
Location:427 → 844

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:48 → 410

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
XM_011250800.4 → XP_011249102.1 glutamate receptor ionotropic, NMDA 2D isoform X3

See identical proteins and their annotated locations for XP_011249102.1

UniProtKB/TrEMBL

C9K0Z4

Conserved Domains (2) summary

cd13718
Location:427 → 844

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:48 → 410

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
XM_030242151.2 → XP_030098011.1 glutamate receptor ionotropic, NMDA 2D isoform X8

UniProtKB/Swiss-Prot

C9K0Z5, Q03391

UniProtKB/TrEMBL

C9K0Z4

Related

ENSMUSP00000002848.8, ENSMUST00000002848.10

Conserved Domains (2) summary

cd13718
Location:427 → 827

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:48 → 410

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
XM_036152689.1 → XP_036008582.1 glutamate receptor ionotropic, NMDA 2D isoform X3

UniProtKB/TrEMBL

C9K0Z4

Conserved Domains (2) summary

cd13718
Location:427 → 844

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:48 → 410

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
XM_030242153.2 → XP_030098013.1 glutamate receptor ionotropic, NMDA 2D isoform X11

Conserved Domains (2) summary

pfam10565
Location:344 → 373

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

cl21456
Location:1 → 307

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_030242152.2 → XP_030098012.1 glutamate receptor ionotropic, NMDA 2D isoform X10

UniProtKB/TrEMBL

C9K0Z4

Conserved Domains (3) summary

PHA03247
Location:1217 → 1313

PHA03247; large tegument protein UL36; Provisional

cd13718
Location:427 → 827

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:48 → 410

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
XM_036152693.1 → XP_036008586.1 glutamate receptor ionotropic, NMDA 2D isoform X12

Conserved Domains (3) summary

pfam00060
Location:603 → 768

Lig_chan; Ligand-gated ion channel

cl10011
Location:156 → 415

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl21456
Location:432 → 773

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily