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    GRB2 growth factor receptor bound protein 2 [ Gallus gallus (chicken) ]

    Gene ID: 386572, updated on 10-Oct-2024

    Summary

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    Symbol
    GRB2provided by CGNC
    Full Name
    growth factor receptor bound protein 2provided by CGNC
    Primary source
    CGNC:6067
    See related
    Ensembl:ENSGALG00010029705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See GRB2 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 18 NC_052549.1 (11374859..11421360, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 18 NC_052590.1 (10975328..11021849, complement)

    Chromosome 18 - NC_052549.1Genomic Context describing neighboring genes Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene uncharacterized LOC121107145 Neighboring gene mitochondrial ribosomal protein S7 Neighboring gene MIF4G domain containing Neighboring gene solute carrier family 25 member 19 Neighboring gene transmembrane protein 94 Neighboring gene CASK interacting protein 2 Neighboring gene melanin-concentrating hormone receptor 1 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene LLGL2, scribble cell polarity complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of the SHC proteins on tyrosine correlates with the transformation of fibroblasts and erythroblasts by the v-sea tyrosine kinase. Crowe AJ, et al. Oncogene, 1994 Feb. PMID 8290264
    2. Sequence of a chicken cDNA encoding a GRB2 protein. Wasenius VM, et al. Gene, 1993 Dec 8. PMID 8262390
    3. The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner. Manno B, et al. Eur J Immunol, 2016 Nov. PMID 27550373
    4. Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes. Stork B, et al. Immunity, 2004 Nov. PMID 15539154
    5. Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells. Stork B, et al. EMBO J, 2007 Feb 21. PMID 17290227, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SHIP individually binds both components of the negative regulatory adaptor complex Dok-3 and Grb2;. Trimolecular complex formation between SHIP, Dok-3 and Grb2 is complemented by binding of SHIP to phosphorylated Igalpha/Igbeta for stable association in BCR signalosomes
      Title: The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner.
    2. The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters
      Title: The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    growth factor receptor-bound protein 2
    Names
    SH2/SH3 adapter GRB2
    adapter protein GRB2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398121.1 → NP_001385050.1  growth factor receptor-bound protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000317
      UniProtKB/TrEMBL
      A3R0S3
      Conserved Domains (3) summary
      cd09941
      Location:56 → 150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:1 → 56
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160 → 212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    2. NM_001398122.1 → NP_001385051.1  growth factor receptor-bound protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000317
      UniProtKB/TrEMBL
      A3R0S3
      Conserved Domains (3) summary
      cd09941
      Location:56 → 150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:1 → 56
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160 → 212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    3. NM_001398123.1 → NP_001385052.1  growth factor receptor-bound protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000317
      UniProtKB/TrEMBL
      A3R0S3
      Related
      ENSGALP00010044538.1, ENSGALT00010071848.1
      Conserved Domains (3) summary
      cd09941
      Location:56 → 150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:1 → 56
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160 → 212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    4. NM_001398124.1 → NP_001385053.1  growth factor receptor-bound protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000317
      UniProtKB/TrEMBL
      A0A8V1APV6
      Conserved Domains (3) summary
      cd09941
      Location:78 → 172
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:1 → 78
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:182 → 234
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    5. NM_204411.2 → NP_989742.2  growth factor receptor-bound protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000317
      UniProtKB/TrEMBL
      A3R0S3
      Conserved Domains (3) summary
      cd09941
      Location:56 → 150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:1 → 56
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160 → 212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052549.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      11374859..11421360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046901968.1 → XP_046757924.1  growth factor receptor-bound protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V1APV6

    2. XM_015295375.4 → XP_015150861.1  growth factor receptor-bound protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q07883
      UniProtKB/TrEMBL
      A0A8V1APV6
      Related
      ENSGALP00010044539.1, ENSGALT00010071849.1
      Conserved Domains (3) summary
      cd09941
      Location:78 → 172
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:1 → 78
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:182 → 234
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    3. XM_015295374.4 → XP_015150860.1  growth factor receptor-bound protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q07883
      UniProtKB/TrEMBL
      A0A8V1APV6
      Conserved Domains (3) summary
      cd09941
      Location:78 → 172
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:1 → 78
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:182 → 234
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    4. XM_025141539.3 → XP_024997307.1  growth factor receptor-bound protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q07883
      UniProtKB/TrEMBL
      A0A8V1APV6
      Conserved Domains (3) summary
      cd09941
      Location:78 → 172
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:1 → 78
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:182 → 234
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052590.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      10975328..11021849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046929249.1 → XP_046785205.1  growth factor receptor-bound protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V1APV6

    2. XM_046929248.1 → XP_046785204.1  growth factor receptor-bound protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V1APV6

    3. XM_046929247.1 → XP_046785203.1  growth factor receptor-bound protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V1APV6

    4. XM_046929250.1 → XP_046785206.1  growth factor receptor-bound protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V1APV6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07883.1 GenPept UniProtKB/Swiss-Prot:Q07883

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