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    HTR2B 5-hydroxytryptamine receptor 2B [ Bos taurus (domestic cattle) ]

    Gene ID: 407135, updated on 1-Jan-2025

    Summary

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    Official Symbol
    HTR2Bprovided by VGNC
    Official Full Name
    5-hydroxytryptamine receptor 2Bprovided by VGNC
    Primary source
    VGNC:VGNC:29997
    See related
    BGD:BT11519; Ensembl:ENSBTAG00000039772
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    5HT2B; 5-HT2B; 5htr2b
    Orthologs
    human mouse all
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    Genomic context

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    See HTR2B in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (118894096..118909723, complement)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 3 Neighboring gene chromosome 2 C2orf72 homolog Neighboring gene proteasome 26S subunit, non-ATPase 1 Neighboring gene U6 spliceosomal RNA Neighboring gene armadillo repeat containing 9 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. 5-HT(2) receptor-mediated phosphoinositide hydrolysis in bovine ciliary epithelium. Inoue-Matsuhisa E, et al. J Ocul Pharmacol Ther, 2003 Feb. PMID 12648304
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 5-HT(2) receptors are coupled to phospholipase C in bovine ciliary epithelium.
      Title: 5-HT(2) receptor-mediated phosphoinositide hydrolysis in bovine ciliary epithelium.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neurotransmitter receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of behavior IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5-hydroxytryptamine receptor 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205448.1 → NP_001192377.1  5-hydroxytryptamine receptor 2B

      See identical proteins and their annotated locations for NP_001192377.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000002
      UniProtKB/TrEMBL
      F6QI78
      Related
      ENSBTAP00000052700.4, ENSBTAT00000052796.4
      Conserved Domains (2) summary
      pfam00001
      Location:70 → 379
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:70 → 246
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      118894096..118909723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010802399.4 → XP_010800701.1  5-hydroxytryptamine receptor 2B isoform X1

      UniProtKB/TrEMBL
      F6QI78
      Conserved Domains (2) summary
      pfam00001
      Location:29 → 338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:29 → 205
      7tm_4; Olfactory receptor

    2. XM_024999400.2 → XP_024855168.1  5-hydroxytryptamine receptor 2B isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:10 → 32
      7tm_GPCRs; TM helix 3 [structural motif]
      cl28897
      Location:1 → 279
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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