Nr1h2 nuclear receptor subfamily 1, group H, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nr1h2provided by RGD
Official Full Name: nuclear receptor subfamily 1, group H, member 2provided by RGD
Primary source: RGD:61906
See related: EnsemblRapid:ENSRNOG00000019812 AllianceGenome:RGD:61906
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LXRB; OR-1; LXRbeta; LXR beta
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear retinoid X receptor binding activity. Contributes to sequence-specific DNA binding activity. Involved in regulation of gene expression; response to nutrient levels; and retinoic acid receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Biomarker of obesity. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR1H2 (nuclear receptor subfamily 1 group H member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 230.4), Lung (RPKM 225.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (104178483..104183863, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (95041967..95047358, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (100554577..100559896, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The present work's main objective was to study the effect of different high fat diets on LXRs expression (in hypothalamus and liver), and lipid profile.
Title: High-Fat Diets and LXRs Expression in Rat Liver and Hypothalamus.
We observed increased expression of LXRalpha from an early stage of nephrosis. To explore the role of increased LXRalpha in diseased kidney in vitro, NRK52E, normal kidney tubular epithelial cells, were forced to overexpress LXRalpha. These cells showed significantly lower lipid accumulation than mock cells did. In contrast, LXRbeta knockdown led to increased lipid accumulation in mock cells, and constancy in overexpre...
Title: Each liver X receptor (LXR) type has a different purpose in different situations.
Results show that hippocampal LXRbeta levels were negatively correlated with the severity of the depressive-like behaviors. LXRbeta knockdown in hippocampus produced depression-like behaviors and impaired hippocampal neurogenesis, and conversely, the LXRbeta activation improved the depression-like behaviors and reversed the impaired hippocampal neurogenesis in rats.
Title: Liver X receptor β in the hippocampus: A potential novel target for the treatment of major depressive disorder?
SHP promoted SUMO1 attachment to LXRbeta by stabilizing the E3 SUMO ligase PIAS1.
Title: Small heterodimer partner SHP mediates liver X receptor (LXR)-dependent suppression of inflammatory signaling by promoting LXR SUMOylation specifically in astrocytes.
Data show that TO901317 increased expression of both Liver X receptors (LXRalpha and LXRbeta) isoforms and its target genes: sterol response element binding protein 1c (SREBP-1c) and acetyl-coenzyme A carboxylase 1 (ACC1) in the heart of streptozotocin-diabetes.
Title: Liver X Receptor Agonist TO901317 Prevents Diacylglycerols Accumulation in the Heart of Streptozotocin-Diabetic Rats.
LXR-beta has roles in regulation of endothelial cellular senescence, related to its antiatherogenic properties
Title: Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes.
Data indicate that myelin alters the macrophage Phenotype by activating the liver-X-receptor beta (LXRbeta) isoform.
Title: Myelin-derived lipids modulate macrophage activity by liver X receptor activation.
Agonists for LXR-beta and peroxisome proliferator-activated receptor delta induce vectorial cholesterol transport through the cholangiocyte basolateral membrane via ATP-binding cassette cholesterol transporter A1 induction.
Title: Liver X receptor β and peroxisome proliferator-activated receptor δ regulate cholesterol transport in murine cholangiocytes.
LXRs may trigger neurochemical and neurophysiological responses for the control of food intake and energy expenditure through these receptors.
Title: Alterations of LXRα and LXRβ expression in the hypothalamus of glucose-intolerant rats.
Elevated insulin secretion from liver X receptor-activated pancreatic beta-cells involves increased de novo lipid synthesis and triacylglyceride turnover.
Title: Elevated insulin secretion from liver X receptor-activated pancreatic beta-cells involves increased de novo lipid synthesis and triacylglyceride turnover.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

AJ132602 (e-PCR)
- UniSTS:185710

AA891955 (e-PCR)
- UniSTS:250032

RH140629 (e-PCR)
- UniSTS:222698

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables apolipoprotein A-I receptor binding	IEA Inferred from Electronic Annotation more info
enables apolipoprotein A-I receptor binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear retinoid X receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear retinoid X receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear retinoid X receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear retinoid X receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol storage	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cholesterol storage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of lipid transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lipid transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of pinocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of pinocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteolysis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine acyl-chain remodeling	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine acyl-chain remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of high-density lipoprotein particle assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of high-density lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid storage	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipoprotein lipase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pancreatic juice secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of pancreatic juice secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of secretion of lysosomal enzymes	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of secretion of lysosomal enzymes	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinoic acid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: oxysterols receptor LXR-beta

Names: UR; liver X receptor beta; nuclear orphan receptor LXR-beta; orphan nuclear receptor OR-1; ubiquitous receptor; ubiquitously-expressed nuclear receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398609.1 → NP_001385538.1 oxysterols receptor LXR-beta isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q62694, Q62755

UniProtKB/TrEMBL

A6JAR1, A9UMV6

Related

ENSRNOP00000026862.5, ENSRNOT00000026862.7

Conserved Domains (2) summary

cd06954
Location:209 → 444

NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors

cl02596
Location:58 → 154

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
NM_001398610.1 → NP_001385539.1 oxysterols receptor LXR-beta isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q62694, Q62755

UniProtKB/TrEMBL

A6JAR1, A9UMV6

Conserved Domains (2) summary

cd06954
Location:209 → 444

NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors

cl02596
Location:58 → 154

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
NM_001398611.1 → NP_001385540.1 oxysterols receptor LXR-beta isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8L2QE94, A9UMV6

Conserved Domains (2) summary

cd06954
Location:206 → 441

NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors

cl02596
Location:55 → 151

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
NM_031626.3 → NP_113814.2 oxysterols receptor LXR-beta isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8L2QE94, A9UMV6

Conserved Domains (2) summary

cd06954
Location:206 → 441

NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors

cl02596
Location:55 → 151

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

104178483..104183863 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088764.2 → XP_038944692.1 oxysterols receptor LXR-beta isoform X1

UniProtKB/TrEMBL

A9UMV6

Conserved Domains (2) summary

cd06954
Location:138 → 373

NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors

cl02596
Location:1 → 83

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers