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    PEAK1 pseudopodium enriched atypical kinase 1 [ Homo sapiens (human) ]

    Gene ID: 79834, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PEAK1provided by HGNC
    Official Full Name
    pseudopodium enriched atypical kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:29431
    See related
    Ensembl:ENSG00000173517 MIM:614248; AllianceGenome:HGNC:29431
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SGK269
    Summary
    This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]
    Expression
    Ubiquitous expression in spleen (RPKM 15.5), lung (RPKM 8.0) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PEAK1 in Genome Data Viewer
    Location:
    15q24.3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (77100654..77420914, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (74961123..75281210, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (77400500..77712446, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9885 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77306630-77307130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77311440-77312012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77325558-77326195 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77326833-77327470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77327471-77328106 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:77335480-77336679 Neighboring gene proline-serine-threonine phosphatase interacting protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6695 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77376319-77376819 Neighboring gene tetraspanin 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:77406591-77406779 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77429442-77429992 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77448039-77448540 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77448541-77449040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9893 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 27 Neighboring gene long intergenic non-protein coding RNA 597 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:77574557-77575155 Neighboring gene MPRA-validated peak2392 silencer Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:77708008-77708676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6698 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9896 Neighboring gene high mobility group 20A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77789555-77790354 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77787952-77788752 Neighboring gene Sharpr-MPRA regulatory region 2172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77799871-77800847 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77801824-77802800 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77802801-77803775 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77817641-77818484 Neighboring gene uncharacterized LOC101929457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77819329-77820172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77821015-77821858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77821859-77822700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77822701-77823544 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:77826181-77826682 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:77826683-77827182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77833845-77834524 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:77836028-77836242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77844823-77845466 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77846672-77847265 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77847266-77847858 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77849641-77850232 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77849047-77849640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77857721-77858585 Neighboring gene uncharacterized LOC105370906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77863406-77863906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77863907-77864407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77866115-77866615 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77874268-77874768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77876983-77877794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77892119-77892619 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:77893796-77893952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77897574-77898293 Neighboring gene Sharpr-MPRA regulatory region 5143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77903637-77904464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77906671-77907170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77908397-77909223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77913981-77914496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77914497-77915012 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77916045-77916560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77922113-77922678 Neighboring gene leucine rich repeat and Ig domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Overexpression of PEAK1 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling. Ding C, et al. Cell Death Dis, 2018 Jul 23. PMID 30038287, Free PMC Article
    2. PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFβ Responses in Breast Cancer. Agajanian M, et al. PLoS One, 2015. PMID 26267863, Free PMC Article
    3. Pseudopodium enriched atypical kinase 1(PEAK1) promotes invasion and of melanoma cells by activating JAK/STAT3 signals. Pan M, et al. Bioengineered, 2021 Dec. PMID 34365903, Free PMC Article
    4. PEAK1 promotes invasion and metastasis and confers drug resistance in breast cancer. Wang X, et al. Clin Exp Med, 2022 Aug. PMID 34554318, Free PMC Article
    5. PEAK1, a novel kinase target in the fight against cancer. Kelber JA, et al. Oncotarget, 2010 Jul. PMID 21301050, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosome-delivered circSATB2 targets the miR-330-5p/PEAK1 axis to regulate proliferation, migration and invasion of lung cancer cells.
      Title: Exosome-delivered circSATB2 targets the miR-330-5p/PEAK1 axis to regulate proliferation, migration and invasion of lung cancer cells.
    2. Clinical Significance of PEAK1 Expression and BRAF V600E Mutation in Papillary Thyroid Cancer.
      Title: Clinical Significance of PEAK1 Expression and BRAF V600E Mutation in Papillary Thyroid Cancer.
    3. PEAK1 promotes invasion and metastasis and confers drug resistance in breast cancer.
      Title: PEAK1 promotes invasion and metastasis and confers drug resistance in breast cancer.
    4. PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins.
      Title: PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins.
    5. LncRNA NORAD, sponging miR-363-3p, promotes invasion and EMT by upregulating PEAK1 and activating the ERK signaling pathway in NSCLC cells.
      Title: LncRNA NORAD, sponging miR-363-3p, promotes invasion and EMT by upregulating PEAK1 and activating the ERK signaling pathway in NSCLC cells.
    6. Pseudopodium enriched atypical kinase 1(PEAK1) promotes invasion and of melanoma cells by activating JAK/STAT3 signals.
      Title: Pseudopodium enriched atypical kinase 1(PEAK1) promotes invasion and of melanoma cells by activating JAK/STAT3 signals.
    7. BioID-Screening Identifies PEAK1 and SHP2 as Components of the ALK Proximitome in Neuroblastoma Cells.
      Title: BioID-Screening Identifies PEAK1 and SHP2 as Components of the ALK Proximitome in Neuroblastoma Cells.
    8. AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network.
      Title: AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network.
    9. PEAK1 functions as a tumor promoter in colorectal cancer cells, and its expression is regulated by the EGFR/KRas signaling axis and miR-181d.
      Title: PEAK1, acting as a tumor promoter in colorectal cancer, is regulated by the EGFR/KRas signaling axis and miR-181d.
    10. PEAK1 overexpression could induce epithelial-to-mesenchymal transition (EMT) and the expression of matrix metalloproteinase-2 (MMP2) and MMP9 both in vitro and in vivo, whereas PEAK1 knockout had the opposite effects.
      Title: Overexpression of PEAK1 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21140, FLJ34483, KIAA2002

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of focal adhesion assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inactive tyrosine-protein kinase PEAK1
    Names
    NKF3 kinase family member
    sugen kinase 269
    tyrosine-protein kinase SgK269
    NP_001371955.1
    NP_001371956.1
    NP_001374014.1
    NP_001374015.1
    NP_079052.2
    XP_005254732.1
    XP_011520336.1
    XP_011520337.1
    XP_011520338.1
    XP_011520339.1
    XP_011520340.1
    XP_011520341.1
    XP_011520344.1
    XP_047289010.1
    XP_047289011.1
    XP_047289012.1
    XP_047289013.1
    XP_047289014.1
    XP_047289016.1
    XP_047289017.1
    XP_047289018.1
    XP_047289019.1
    XP_047289020.1
    XP_047289021.1
    XP_047289023.1
    XP_047289024.1
    XP_047289025.1
    XP_047289026.1
    XP_047289027.1
    XP_047289028.1
    XP_047289029.1
    XP_047289030.1
    XP_047289031.1
    XP_047289032.1
    XP_047289033.1
    XP_047289034.1
    XP_054234791.1
    XP_054234792.1
    XP_054234793.1
    XP_054234794.1
    XP_054234795.1
    XP_054234796.1
    XP_054234797.1
    XP_054234798.1
    XP_054234799.1
    XP_054234800.1
    XP_054234801.1
    XP_054234802.1
    XP_054234803.1
    XP_054234804.1
    XP_054234805.1
    XP_054234806.1
    XP_054234807.1
    XP_054234808.1
    XP_054234809.1
    XP_054234810.1
    XP_054234811.1
    XP_054234812.1
    XP_054234813.1
    XP_054234814.1
    XP_054234815.1
    XP_054234816.1
    XP_054234817.1
    XP_054234818.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034037.2 RefSeqGene

      Range
      5810..317756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001385026.1 → NP_001371955.1  inactive tyrosine-protein kinase PEAK1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, 4, and 5 all encode the same isoform (a).
      Source sequence(s)
      AC060773, AC087465, AC090984, AC107883
      Consensus CDS
      CCDS42062.1
      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792
      Related
      ENSP00000507603.1, ENST00000682557.1
      Conserved Domains (1) summary
      cl21453
      Location:1503 → 1668
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001385027.1 → NP_001371956.1  inactive tyrosine-protein kinase PEAK1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC060773, AC087465, AC090984
      UniProtKB/TrEMBL
      H0YN99

    3. NM_001387085.1 → NP_001374014.1  inactive tyrosine-protein kinase PEAK1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 1, 2, and 5, encodes isoform a.
      Source sequence(s)
      AC060773, AC087465, AC090984, AC107883
      Consensus CDS
      CCDS42062.1
      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792
      Conserved Domains (1) summary
      cl21453
      Location:1503 → 1668
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001387086.1 → NP_001374015.1  inactive tyrosine-protein kinase PEAK1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 2, and 4, encodes isoform a.
      Source sequence(s)
      AC060773, AC087465, AC090984, AC107883
      Consensus CDS
      CCDS42062.1
      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792
      Conserved Domains (1) summary
      cl21453
      Location:1503 → 1668
      PKc_like; Protein Kinases, catalytic domain

    5. NM_024776.5 → NP_079052.2  inactive tyrosine-protein kinase PEAK1 isoform a

      See identical proteins and their annotated locations for NP_079052.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (a).
      Source sequence(s)
      AC060773, AC087465, AC090984, AC107883
      Consensus CDS
      CCDS42062.1
      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792
      Conserved Domains (1) summary
      cl21453
      Location:1503 → 1668
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      77100654..77420914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433077.1 → XP_047289033.1  inactive tyrosine-protein kinase PEAK1 isoform X2

    2. XM_047433076.1 → XP_047289032.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    3. XM_047433057.1 → XP_047289013.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    4. XM_047433073.1 → XP_047289029.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    5. XM_047433074.1 → XP_047289030.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    6. XM_047433072.1 → XP_047289028.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    7. XM_047433065.1 → XP_047289021.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    8. XM_047433068.1 → XP_047289024.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    9. XM_047433063.1 → XP_047289019.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792
      Related
      ENSP00000452796.2, ENST00000560626.6

    10. XM_047433067.1 → XP_047289023.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    11. XM_047433055.1 → XP_047289011.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    12. XM_047433054.1 → XP_047289010.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    13. XM_047433061.1 → XP_047289017.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    14. XM_011522038.3 → XP_011520340.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      See identical proteins and their annotated locations for XP_011520340.1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792
      Conserved Domains (1) summary
      cl21453
      Location:1503 → 1668
      PKc_like; Protein Kinases, catalytic domain

    15. XM_011522039.3 → XP_011520341.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      See identical proteins and their annotated locations for XP_011520341.1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792
      Conserved Domains (1) summary
      cl21453
      Location:1503 → 1668
      PKc_like; Protein Kinases, catalytic domain

    16. XM_011522034.3 → XP_011520336.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      See identical proteins and their annotated locations for XP_011520336.1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792
      Conserved Domains (1) summary
      cl21453
      Location:1503 → 1668
      PKc_like; Protein Kinases, catalytic domain

    17. XM_011522036.3 → XP_011520338.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      See identical proteins and their annotated locations for XP_011520338.1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792
      Conserved Domains (1) summary
      cl21453
      Location:1503 → 1668
      PKc_like; Protein Kinases, catalytic domain

    18. XM_011522037.3 → XP_011520339.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      See identical proteins and their annotated locations for XP_011520339.1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792
      Conserved Domains (1) summary
      cl21453
      Location:1503 → 1668
      PKc_like; Protein Kinases, catalytic domain

    19. XM_011522035.3 → XP_011520337.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      See identical proteins and their annotated locations for XP_011520337.1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792
      Conserved Domains (1) summary
      cl21453
      Location:1503 → 1668
      PKc_like; Protein Kinases, catalytic domain

    20. XM_047433060.1 → XP_047289016.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    21. XM_047433056.1 → XP_047289012.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    22. XM_047433069.1 → XP_047289025.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    23. XM_047433064.1 → XP_047289020.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    24. XM_047433070.1 → XP_047289026.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    25. XM_047433058.1 → XP_047289014.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    26. XM_047433062.1 → XP_047289018.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    27. XM_047433071.1 → XP_047289027.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    28. XM_047433075.1 → XP_047289031.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792

    29. XM_005254675.5 → XP_005254732.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      See identical proteins and their annotated locations for XP_005254732.1

      UniProtKB/Swiss-Prot
      Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7, Q9H792
      Related
      ENSP00000309230.4, ENST00000312493.5
      Conserved Domains (1) summary
      cl21453
      Location:1503 → 1668
      PKc_like; Protein Kinases, catalytic domain

    30. XM_011522042.3 → XP_011520344.1  inactive tyrosine-protein kinase PEAK1 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:465 → 628
      PKc_like; Protein Kinases, catalytic domain

    31. XM_047433078.1 → XP_047289034.1  inactive tyrosine-protein kinase PEAK1 isoform X3

      UniProtKB/TrEMBL
      H0YN99

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      74961123..75281210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378841.1 → XP_054234816.1  inactive tyrosine-protein kinase PEAK1 isoform X2

    2. XM_054378840.1 → XP_054234815.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    3. XM_054378819.1 → XP_054234794.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    4. XM_054378838.1 → XP_054234813.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    5. XM_054378837.1 → XP_054234812.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    6. XM_054378831.1 → XP_054234806.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    7. XM_054378833.1 → XP_054234808.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    8. XM_054378827.1 → XP_054234802.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    9. XM_054378832.1 → XP_054234807.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    10. XM_054378818.1 → XP_054234793.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    11. XM_054378817.1 → XP_054234792.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    12. XM_054378826.1 → XP_054234801.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    13. XM_054378825.1 → XP_054234800.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    14. XM_054378824.1 → XP_054234799.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    15. XM_054378816.1 → XP_054234791.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    16. XM_054378822.1 → XP_054234797.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    17. XM_054378821.1 → XP_054234796.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    18. XM_054378820.1 → XP_054234795.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    19. XM_054378823.1 → XP_054234798.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    20. XM_054378835.1 → XP_054234810.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    21. XM_054378830.1 → XP_054234805.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    22. XM_054378834.1 → XP_054234809.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    23. XM_054378828.1 → XP_054234803.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    24. XM_054378829.1 → XP_054234804.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    25. XM_054378839.1 → XP_054234814.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    26. XM_054378836.1 → XP_054234811.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    27. XM_054378843.1 → XP_054234818.1  inactive tyrosine-protein kinase PEAK1 isoform X4

    28. XM_054378842.1 → XP_054234817.1  inactive tyrosine-protein kinase PEAK1 isoform X3

      UniProtKB/TrEMBL
      H0YN99
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H792.4 GenPept UniProtKB/Swiss-Prot:Q9H792

    Gene LinkOut

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