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    Rad23a RAD23 homolog A, nucleotide excision repair protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361381, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rad23aprovided by RGD
    Official Full Name
    RAD23 homolog A, nucleotide excision repair proteinprovided by RGD
    Primary source
    RGD:1309899
    See related
    EnsemblRapid:ENSRNOG00000003026 AllianceGenome:RGD:1309899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including enzyme binding activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in several processes, including positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of viral genome replication; and protein destabilization. Predicted to act upstream of or within DNA damage response. Predicted to be located in Golgi apparatus and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleoplasm. Orthologous to human RAD23A (RAD23 homolog A, nucleotide excision repair protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 292.7), Spleen (RPKM 265.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rad23a in Genome Data Viewer
    Location:
    19q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40219235..40225543)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23313563..23320702)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25949488..25956677, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene phenylalanyl-tRNA synthetase subunit alpha Neighboring gene GADD45G interacting protein 1 Neighboring gene calreticulin Neighboring gene uncharacterized LOC134483324 Neighboring gene DAN domain BMP antagonist family member 5 Neighboring gene uncharacterized LOC134483325 Neighboring gene nuclear factor I X

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    UV excision repair protein RAD23 homolog A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013190.2NP_001013208.1  UV excision repair protein RAD23 homolog A isoform 1

      See identical proteins and their annotated locations for NP_001013208.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      F7FJT3, Q5XFX7
      Conserved Domains (4) summary
      cd01805
      Location:380
      RAD23_N; Ubiquitin-like domain of RAD23
      cd14377
      Location:162201
      UBA1_Rad23; UBA1 domain of Rad23 proteins found in metazoa
      TIGR00601
      Location:3325
      rad23; UV excision repair protein Rad23
      pfam09280
      Location:231286
      XPC-binding; XPC-binding domain
    2. NM_001399101.1NP_001386030.1  UV excision repair protein RAD23 homolog A isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IY71, F7FJT3
      Conserved Domains (1) summary
      TIGR00601
      Location:3361
      rad23; UV excision repair protein Rad23
    3. NM_001399102.1NP_001386031.1  UV excision repair protein RAD23 homolog A isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      F7FJT3
      Related
      ENSRNOP00000004042.6, ENSRNOT00000004042.7
      Conserved Domains (1) summary
      TIGR00601
      Location:3360
      rad23; UV excision repair protein Rad23

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      40219235..40225543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772411.4XP_008770633.1  UV excision repair protein RAD23 homolog A isoform X1

      UniProtKB/TrEMBL
      F7FJT3
      Conserved Domains (4) summary
      cd01805
      Location:380
      RAD23_N; Ubiquitin-like domain of RAD23
      smart00213
      Location:377
      UBQ; Ubiquitin homologues
      cd14377
      Location:162201
      UBA1_Rad23; UBA1 domain of Rad23 proteins found in metazoa
      pfam09280
      Location:232287
      XPC-binding; XPC-binding domain

    RNA

    1. XR_010060012.1 RNA Sequence