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    MIR100HG mir-100-let-7a-2-mir-125b-1 cluster host gene [ Homo sapiens (human) ]

    Gene ID: 399959, updated on 10-Dec-2024

    Summary

    Official Symbol
    MIR100HGprovided by HGNC
    Official Full Name
    mir-100-let-7a-2-mir-125b-1 cluster host geneprovided by HGNC
    Primary source
    HGNC:HGNC:39522
    See related
    Ensembl:ENSG00000255248 MIM:615965; AllianceGenome:HGNC:39522
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AGD1; lncRNA-N2; linc-NeD125
    Summary
    This gene produces long non-coding RNAs that act as regulators of cell proliferation. Alternative promoter usage and splicing results in multiple transcript variants. Some transcript variants may promote growth, while others may act to negatively regulate cell division. [provided by RefSeq, May 2016]
    Expression
    Broad expression in ovary (RPKM 32.2), gall bladder (RPKM 20.3) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MIR100HG in Genome Data Viewer
    Location:
    11q24.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (122028329..122422871, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (122057374..122452245, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (121899037..122293579, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984402 Neighboring gene VISTA enhancer hs872 Neighboring gene RNA, U6 small nuclear 256, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:121976285-121976785 Neighboring gene microRNA 125b-1 Neighboring gene microRNA let-7a-2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:122050835-122052034 Neighboring gene BH3-like motif containing, cell death inducer Neighboring gene microRNA 10526 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:122067486-122068685 Neighboring gene microRNA 100 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:122100557-122101387 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:122244306-122244840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4007 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:122292931-122294130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:122312133-122312797 Neighboring gene RNA, U4atac small nuclear 10, pseudogene Neighboring gene RNA, U4atac small nuclear 5, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association analysis identified a novel susceptible locus for pathological myopia at 11q24.1.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Other Names

    • adipogenesis down-regulated transcript 1
    • lncRNA neuronal 2
    • mir-100-let-7a-2 cluster host gene (non-protein coding)
    • neuronal differentiation lncRNA hosting miR-125

    Clone Names

    • FLJ11490, FLJ18351, FLJ34394, FLJ41953, DKFZp686L0115, DKFZp686J24156

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024430.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the reference variant.
      Source sequence(s)
      AK311309, AP000755, AP001924
    2. NR_137175.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924
      Related
      ENST00000529823.3
    3. NR_137176.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as linc-NeD125) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, BC040599, BX538058
    4. NR_137177.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, BC040599, BX538058, BX647608
      Related
      ENST00000524376.3
    5. NR_137178.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) represents use of an alternate promoter, differs in the 5' and 3' exon structure, and is shorter than variant 1.
      Source sequence(s)
      AP001924, BC089451
    6. NR_137179.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA861327
      Related
      ENST00000780377.1
    7. NR_137180.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA788103, DA808613
    8. NR_137181.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000755, AP001924, DA153922
    9. NR_137182.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AB485963, AP000755, AP001924
      Related
      ENST00000664908.2
    10. NR_137183.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA474693, DA650430
      Related
      ENST00000656793.2
    11. NR_137184.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA474693, DA659486
    12. NR_137185.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA474693, DA649890
    13. NR_137186.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA597554
      Related
      ENST00000660603.1
    14. NR_137187.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA027094, DA597554
      Related
      ENST00000648209.1
    15. NR_137188.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001359, AP001924, DA349788
    16. NR_137189.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA769636
      Related
      ENST00000654519.2
    17. NR_137190.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA532588
      Related
      ENST00000531071.6
    18. NR_137191.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DB248200
      Related
      ENST00000532890.6
    19. NR_137192.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP000755, AP001359, AP001835, AP001924
      Related
      ENST00000661848.1
    20. NR_137193.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP000755, AP001359, AP001924, KF459774
      Related
      ENST00000662950.1
    21. NR_137194.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001359, AP001924, KF459774
      Related
      ENST00000663296.1
    22. NR_137195.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924
      Related
      ENST00000658364.2
    23. NR_137196.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924
      Related
      ENST00000653167.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      122028329..122422871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      122057374..122452245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)