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    SMC2 structural maintenance of chromosomes 2 [ Homo sapiens (human) ]

    Gene ID: 10592, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SMC2provided by HGNC
    Official Full Name
    structural maintenance of chromosomes 2provided by HGNC
    Primary source
    HGNC:HGNC:14011
    See related
    Ensembl:ENSG00000136824 MIM:605576; AllianceGenome:HGNC:14011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAPE; CAP-E; SMC-2; SMC2L1
    Summary
    Predicted to enable chromatin binding activity. Involved in mitotic chromosome condensation and positive regulation of chromosome condensation. Located in condensed chromosome; cytoplasm; and nuclear lumen. Part of condensin complex. Implicated in colon adenocarcinoma. Biomarker of colorectal cancer. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 6.5), testis (RPKM 6.0) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SMC2 in Genome Data Viewer
    Location:
    9q31.1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (104088263..104141419)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (116267420..116315130)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (106856590..106903700)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376192 Neighboring gene uncharacterized LOC105376193 Neighboring gene long intergenic non-protein coding RNA 3094 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:106855873-106856542 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:106856543-106857210 Neighboring gene SMC2 divergent transcript Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:106994559-106995758 Neighboring gene uncharacterized LOC105376194 Neighboring gene topoisomerase I binding, arginine and serine rich like, pseudogene Neighboring gene WDR45-like pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Structural maintenance of chromosomes 2 is identified as an oncogene in bladder cancer in vitro and in vivo. Han YH, et al. Neoplasma, 2020 Mar. PMID 31986889
    2. Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells. Murakami-Tonami Y, et al. Cell Cycle, 2014. PMID 24553121, Free PMC Article
    3. Streptavidin-Binding Peptide (SBP)-tagged SMC2 allows single-step affinity fluorescence, blotting or purification of the condensin complex. Kim JH, et al. BMC Biochem, 2010 Dec 31. PMID 21194474, Free PMC Article
    4. Cloning, expression, crystallization and preliminary X-ray crystallographic analysis of a human condensin SMC2 hinge domain with short coiled coils. Kawahara K, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Sep 1. PMID 20823528, Free PMC Article
    5. SMC2 knockdown inhibits malignant progression of lung adenocarcinoma by upregulating BTG2 expression. He Y, et al. Cell Signal, 2024 Aug. PMID 38729325

    See all (180) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SMC2 knockdown inhibits malignant progression of lung adenocarcinoma by upregulating BTG2 expression.
      Title: SMC2 knockdown inhibits malignant progression of lung adenocarcinoma by upregulating BTG2 expression.
    2. Structural maintenance of chromosomes 2 is identified as an oncogene in bladder cancer in vitro and in vivo.
      Title: Structural maintenance of chromosomes 2 is identified as an oncogene in bladder cancer in vitro and in vivo.
    3. Rs3818626 and rs9895829 were significantly associated with SMC2 and TP53 messenger RNA expression.
      Title: Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer.
    4. SMC2 (or the condensin complex) is a novel molecular target for the treatment of MYCN-amplified neuroblastoma.
      Title: Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells.
    5. analysis of functional differences of SMC2 and SMC4 hinge domain between condensins and cohesin in DNA recognition
      Title: Structural Basis for Dimer Formation of Human Condensin Structural Maintenance of Chromosome Proteins and Its Implications for Single-stranded DNA Recognition.
    6. SMC2 gene is altered by both frameshift mutation and loss of expression in gastric and colorectal cancers, suggesting that SMC2 gene alterations might be involved in pathogenesis of these cancers
      Title: Mutational and expressional analysis of SMC2 gene in gastric and colorectal cancers with microsatellite instability.
    7. WNT signaling can directly activate SMC2 transcription as a key player in the mitotic cell division machinery.
      Title: Human SMC2 protein, a core subunit of human condensin complex, is a novel transcriptional target of the WNT signaling pathway and a new therapeutic target.
    8. Studies indicate that tagged SMC2 subunit of the condensin complex with the streptavidin-Binding Peptide optimising efficacious use of this tag for protein analysis.
      Title: Streptavidin-Binding Peptide (SBP)-tagged SMC2 allows single-step affinity fluorescence, blotting or purification of the condensin complex.
    9. human SMC2 hinge domain with short coiled coils was cloned, expressed, purified and crystallized in the orthorhombic space group C222 in native and SeMet-derivatized forms
      Title: Cloning, expression, crystallization and preliminary X-ray crystallographic analysis of a human condensin SMC2 hinge domain with short coiled coils.
    10. mutation analysis of hCAP-C & hCAP-E in leukemia-lymphoma cell lines including 8 pyothorax-associated lymphoma (PAL); 3 of 8 PAL cell lines have hCAP-C or hCAP-E heterozygous mutations, indicating condensin mutations are relatively frequent in PAL
      Title: Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
    EBI GWAS Catalog
    Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Interaction of HIV-1 Tat with SMC2 in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10093

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kinetochore organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic chromosome condensation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of chromosome condensation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of chromosome condensation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chromosome separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in condensed chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of condensin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of condensin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    structural maintenance of chromosomes protein 2
    Names
    SMC protein 2
    SMC2 (structural maintenance of chromosomes 2, yeast)-like 1
    XCAP-E homolog
    chromosome-associated protein E
    structural maintenance of chromosomes (SMC) family member, chromosome-associated protein E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042550.2 → NP_001036015.1  structural maintenance of chromosomes protein 2

      See identical proteins and their annotated locations for NP_001036015.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
      Source sequence(s)
      AK001485, AK124957, AL354938, AL833191, BC032705, BF969462
      Consensus CDS
      CCDS35086.1
      UniProtKB/Swiss-Prot
      O95347, Q6IEE0, Q9P1P2
      UniProtKB/TrEMBL
      B7ZLZ7
      Related
      ENSP00000363919.3, ENST00000374787.7
      Conserved Domains (8) summary
      pfam06673
      Location:252 → 465
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      cd03273
      Location:1 → 172
      ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
      smart00968
      Location:522 → 639
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1168
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:740 → 841
      DUF4200; Domain of unknown function (DUF4200)
      pfam15456
      Location:193 → 287
      Uds1; Up-regulated During Septation
      cl19219
      Location:636 → 777
      DUF342; Protein of unknown function (DUF342)
      cl21455
      Location:1074 → 1168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001042551.2 → NP_001036016.1  structural maintenance of chromosomes protein 2

      See identical proteins and their annotated locations for NP_001036016.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AL354938, AL833191, BC032705, BF969462
      Consensus CDS
      CCDS35086.1
      UniProtKB/Swiss-Prot
      O95347, Q6IEE0, Q9P1P2
      UniProtKB/TrEMBL
      B7ZLZ7
      Conserved Domains (8) summary
      pfam06673
      Location:252 → 465
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      cd03273
      Location:1 → 172
      ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
      smart00968
      Location:522 → 639
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1168
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:740 → 841
      DUF4200; Domain of unknown function (DUF4200)
      pfam15456
      Location:193 → 287
      Uds1; Up-regulated During Septation
      cl19219
      Location:636 → 777
      DUF342; Protein of unknown function (DUF342)
      cl21455
      Location:1074 → 1168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001265602.2 → NP_001252531.1  structural maintenance of chromosomes protein 2

      See identical proteins and their annotated locations for NP_001252531.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AK292599, AL833191, BC144163, BF969462, BN000163
      Consensus CDS
      CCDS35086.1
      UniProtKB/Swiss-Prot
      O95347, Q6IEE0, Q9P1P2
      UniProtKB/TrEMBL
      B7ZLZ7
      Related
      ENSP00000286398.7, ENST00000286398.11
      Conserved Domains (8) summary
      pfam06673
      Location:252 → 465
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      cd03273
      Location:1 → 172
      ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
      smart00968
      Location:522 → 639
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1168
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:740 → 841
      DUF4200; Domain of unknown function (DUF4200)
      pfam15456
      Location:193 → 287
      Uds1; Up-regulated During Septation
      cl19219
      Location:636 → 777
      DUF342; Protein of unknown function (DUF342)
      cl21455
      Location:1074 → 1168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_006444.3 → NP_006435.2  structural maintenance of chromosomes protein 2

      See identical proteins and their annotated locations for NP_006435.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AF092563, AK124957, AL354938, AL833191, BC017845, BC032705, BC055081, BF969462
      Consensus CDS
      CCDS35086.1
      UniProtKB/Swiss-Prot
      O95347, Q6IEE0, Q9P1P2
      UniProtKB/TrEMBL
      B7ZLZ7
      Related
      ENSP00000363925.3, ENST00000374793.8
      Conserved Domains (8) summary
      pfam06673
      Location:252 → 465
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      cd03273
      Location:1 → 172
      ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
      smart00968
      Location:522 → 639
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1168
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:740 → 841
      DUF4200; Domain of unknown function (DUF4200)
      pfam15456
      Location:193 → 287
      Uds1; Up-regulated During Septation
      cl19219
      Location:636 → 777
      DUF342; Protein of unknown function (DUF342)
      cl21455
      Location:1074 → 1168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      104088263..104141419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518149.4 → XP_011516451.1  structural maintenance of chromosomes protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011516451.1

      UniProtKB/Swiss-Prot
      O95347, Q6IEE0, Q9P1P2
      UniProtKB/TrEMBL
      B7ZLZ7
      Conserved Domains (8) summary
      pfam06673
      Location:252 → 465
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      cd03273
      Location:1 → 172
      ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
      smart00968
      Location:522 → 639
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1168
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:740 → 841
      DUF4200; Domain of unknown function (DUF4200)
      pfam15456
      Location:193 → 287
      Uds1; Up-regulated During Septation
      cl19219
      Location:636 → 777
      DUF342; Protein of unknown function (DUF342)
      cl21455
      Location:1074 → 1168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_047422644.1 → XP_047278600.1  structural maintenance of chromosomes protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZLZ7

    3. XM_017014210.3 → XP_016869699.1  structural maintenance of chromosomes protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZLZ7
      Conserved Domains (6) summary
      pfam06673
      Location:202 → 415
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      smart00968
      Location:472 → 589
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1118
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:690 → 791
      DUF4200; Domain of unknown function (DUF4200)
      cl19219
      Location:586 → 727
      DUF342; Protein of unknown function (DUF342)
      cl21455
      Location:1024 → 1118
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_017014211.3 → XP_016869700.1  structural maintenance of chromosomes protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZLZ7
      Conserved Domains (6) summary
      pfam06673
      Location:202 → 415
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      smart00968
      Location:472 → 589
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1118
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:690 → 791
      DUF4200; Domain of unknown function (DUF4200)
      cl19219
      Location:586 → 727
      DUF342; Protein of unknown function (DUF342)
      cl21455
      Location:1024 → 1118
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_011518150.3 → XP_011516452.1  structural maintenance of chromosomes protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011516452.1

      UniProtKB/TrEMBL
      B7ZLZ7
      Conserved Domains (6) summary
      pfam06673
      Location:202 → 415
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      smart00968
      Location:472 → 589
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1118
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:690 → 791
      DUF4200; Domain of unknown function (DUF4200)
      cl19219
      Location:586 → 727
      DUF342; Protein of unknown function (DUF342)
      cl21455
      Location:1024 → 1118
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    6. XM_006716933.4 → XP_006716996.1  structural maintenance of chromosomes protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006716996.1

      UniProtKB/Swiss-Prot
      O95347, Q6IEE0, Q9P1P2
      UniProtKB/TrEMBL
      B7ZLZ7
      Conserved Domains (8) summary
      pfam06673
      Location:252 → 465
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      cd03273
      Location:1 → 172
      ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
      smart00968
      Location:522 → 639
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1168
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:740 → 841
      DUF4200; Domain of unknown function (DUF4200)
      pfam15456
      Location:193 → 287
      Uds1; Up-regulated During Septation
      cl19219
      Location:636 → 777
      DUF342; Protein of unknown function (DUF342)
      cl21455
      Location:1074 → 1168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    7. XM_011518151.3 → XP_011516453.1  structural maintenance of chromosomes protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011516453.1

      UniProtKB/TrEMBL
      B7ZLZ7
      Conserved Domains (6) summary
      pfam06673
      Location:202 → 415
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      smart00968
      Location:472 → 589
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1118
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:690 → 791
      DUF4200; Domain of unknown function (DUF4200)
      cl19219
      Location:586 → 727
      DUF342; Protein of unknown function (DUF342)
      cl21455
      Location:1024 → 1118
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    8. XM_047422648.1 → XP_047278604.1  structural maintenance of chromosomes protein 2 isoform X3

      UniProtKB/TrEMBL
      B7ZLZ7

    9. XM_047422649.1 → XP_047278605.1  structural maintenance of chromosomes protein 2 isoform X5

      UniProtKB/TrEMBL
      B7ZLZ7

    10. XM_011518153.2 → XP_011516455.1  structural maintenance of chromosomes protein 2 isoform X4

      See identical proteins and their annotated locations for XP_011516455.1

      UniProtKB/TrEMBL
      B7ZLZ7
      Conserved Domains (7) summary
      pfam06673
      Location:252 → 465
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      cd03273
      Location:1 → 172
      ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
      smart00968
      Location:522 → 639
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1090
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:740 → 841
      DUF4200; Domain of unknown function (DUF4200)
      cl19219
      Location:636 → 777
      DUF342; Protein of unknown function (DUF342)
      cl21455
      Location:1074 → 1090
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    11. XM_024447383.2 → XP_024303151.1  structural maintenance of chromosomes protein 2 isoform X6

      UniProtKB/TrEMBL
      Q2KQ72
      Conserved Domains (1) summary
      COG1196
      Location:1 → 713
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    12. XM_017014206.2 → XP_016869695.1  structural maintenance of chromosomes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O95347, Q6IEE0, Q9P1P2
      UniProtKB/TrEMBL
      B7ZLZ7
      Conserved Domains (8) summary
      pfam06673
      Location:252 → 465
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      cd03273
      Location:1 → 172
      ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
      smart00968
      Location:522 → 639
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1168
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:740 → 841
      DUF4200; Domain of unknown function (DUF4200)
      pfam15456
      Location:193 → 287
      Uds1; Up-regulated During Septation
      cl19219
      Location:636 → 777
      DUF342; Protein of unknown function (DUF342)
      cl21455
      Location:1074 → 1168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    13. XM_047422647.1 → XP_047278603.1  structural maintenance of chromosomes protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZLZ7

    14. XM_017014209.2 → XP_016869698.1  structural maintenance of chromosomes protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZLZ7
      Conserved Domains (6) summary
      pfam06673
      Location:202 → 415
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      smart00968
      Location:472 → 589
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1118
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:690 → 791
      DUF4200; Domain of unknown function (DUF4200)
      cl19219
      Location:586 → 727
      DUF342; Protein of unknown function (DUF342)
      cl21455
      Location:1024 → 1118
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    15. XM_017014208.2 → XP_016869697.1  structural maintenance of chromosomes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O95347, Q6IEE0, Q9P1P2
      UniProtKB/TrEMBL
      B7ZLZ7
      Conserved Domains (8) summary
      pfam06673
      Location:252 → 465
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      cd03273
      Location:1 → 172
      ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
      smart00968
      Location:522 → 639
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1168
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:740 → 841
      DUF4200; Domain of unknown function (DUF4200)
      pfam15456
      Location:193 → 287
      Uds1; Up-regulated During Septation
      cl19219
      Location:636 → 777
      DUF342; Protein of unknown function (DUF342)
      cl21455
      Location:1074 → 1168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    16. XM_047422646.1 → XP_047278602.1  structural maintenance of chromosomes protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZLZ7

    17. XM_011518148.3 → XP_011516450.1  structural maintenance of chromosomes protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011516450.1

      UniProtKB/Swiss-Prot
      O95347, Q6IEE0, Q9P1P2
      UniProtKB/TrEMBL
      B7ZLZ7
      Conserved Domains (8) summary
      pfam06673
      Location:252 → 465
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      cd03273
      Location:1 → 172
      ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
      smart00968
      Location:522 → 639
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1168
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:740 → 841
      DUF4200; Domain of unknown function (DUF4200)
      pfam15456
      Location:193 → 287
      Uds1; Up-regulated During Septation
      cl19219
      Location:636 → 777
      DUF342; Protein of unknown function (DUF342)
      cl21455
      Location:1074 → 1168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    18. XM_017014212.2 → XP_016869701.1  structural maintenance of chromosomes protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZLZ7
      Conserved Domains (6) summary
      pfam06673
      Location:202 → 415
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      smart00968
      Location:472 → 589
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1118
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:690 → 791
      DUF4200; Domain of unknown function (DUF4200)
      cl19219
      Location:586 → 727
      DUF342; Protein of unknown function (DUF342)
      cl21455
      Location:1024 → 1118
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      116267420..116315130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361769.1 → XP_054217744.1  structural maintenance of chromosomes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O95347, Q6IEE0, Q9P1P2
      UniProtKB/TrEMBL
      B7ZLZ7

    2. XM_054361776.1 → XP_054217751.1  structural maintenance of chromosomes protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZLZ7

    3. XM_054361767.1 → XP_054217742.1  structural maintenance of chromosomes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O95347, Q6IEE0, Q9P1P2
      UniProtKB/TrEMBL
      B7ZLZ7

    4. XM_054361774.1 → XP_054217749.1  structural maintenance of chromosomes protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZLZ7

    5. XM_054361770.1 → XP_054217745.1  structural maintenance of chromosomes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O95347, Q6IEE0, Q9P1P2
      UniProtKB/TrEMBL
      B7ZLZ7

    6. XM_054361775.1 → XP_054217750.1  structural maintenance of chromosomes protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZLZ7

    7. XM_054361780.1 → XP_054217755.1  structural maintenance of chromosomes protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZLZ7

    8. XM_054361773.1 → XP_054217748.1  structural maintenance of chromosomes protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZLZ7

    9. XM_054361782.1 → XP_054217757.1  structural maintenance of chromosomes protein 2 isoform X3

      UniProtKB/TrEMBL
      B7ZLZ7

    10. XM_054361784.1 → XP_054217759.1  structural maintenance of chromosomes protein 2 isoform X5

      UniProtKB/TrEMBL
      B7ZLZ7

    11. XM_054361783.1 → XP_054217758.1  structural maintenance of chromosomes protein 2 isoform X4

      UniProtKB/TrEMBL
      B7ZLZ7

    12. XM_054361785.1 → XP_054217760.1  structural maintenance of chromosomes protein 2 isoform X6

      UniProtKB/TrEMBL
      Q2KQ72

    13. XM_054361772.1 → XP_054217747.1  structural maintenance of chromosomes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O95347, Q6IEE0, Q9P1P2
      UniProtKB/TrEMBL
      B7ZLZ7

    14. XM_054361771.1 → XP_054217746.1  structural maintenance of chromosomes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O95347, Q6IEE0, Q9P1P2
      UniProtKB/TrEMBL
      B7ZLZ7

    15. XM_054361779.1 → XP_054217754.1  structural maintenance of chromosomes protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZLZ7

    16. XM_054361777.1 → XP_054217752.1  structural maintenance of chromosomes protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZLZ7

    17. XM_054361768.1 → XP_054217743.1  structural maintenance of chromosomes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O95347, Q6IEE0, Q9P1P2
      UniProtKB/TrEMBL
      B7ZLZ7

    18. XM_054361781.1 → XP_054217756.1  structural maintenance of chromosomes protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZLZ7

    19. XM_054361778.1 → XP_054217753.1  structural maintenance of chromosomes protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZLZ7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95347.2 GenPept UniProtKB/Swiss-Prot:O95347

    Gene LinkOut

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