Mfsd5 major facilitator superfamily domain containing 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mfsd5provided by MGI
Official Full Name: major facilitator superfamily domain containing 5provided by MGI
Primary source: MGI:MGI:2145901
See related: Ensembl:ENSMUSG00000045665 AllianceGenome:MGI:2145901
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AW556797; D15Mgi27
Summary: Predicted to enable molybdate ion transmembrane transporter activity. Predicted to be involved in molybdate ion transport. Predicted to be located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system; liver; and spinal cord. Orthologous to human MFSD5 (major facilitator superfamily domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 50.9), mammary gland adult (RPKM 49.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F2; 15 57.44 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (102187891..102190179)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (102279456..102281744)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that Mfsd5 and Mfsd11 are both affected by altered energy homeostasis, suggesting plausible involvement in the energy regulation. Moreover, the first histological mapping of MFSD5 and MFSD11 shows ubiquitous expression in the periphery and the central nervous system of mice, where the proteins are expressed in excitatory and inhibitory mouse brain neurons.
Title: The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124854 (e-PCR)
- UniSTS:161676

AW556797 (e-PCR)
- UniSTS:186050

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables molybdate ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables molybdate ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in molybdate ion transport	IEA Inferred from Electronic Annotation more info
involved_in molybdate ion transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: molybdate-anion transporter

Names: major facilitator superfamily domain-containing protein 5; molybdate transporter 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134100.4 → NP_598861.1 molybdate-anion transporter

See identical proteins and their annotated locations for NP_598861.1

Status: PROVISIONAL

Source sequence(s)

AK089268

Consensus CDS

CCDS27877.1

UniProtKB/Swiss-Prot

Q921Y4

Related

ENSMUSP00000061997.5, ENSMUST00000051341.6

Conserved Domains (1) summary

cl21472
Location:6 → 328

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...