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    CDKN2A cyclin dependent kinase inhibitor 2A [ Canis lupus familiaris (dog) ]

    Gene ID: 100271861, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CDKN2Aprovided by VGNC
    Official Full Name
    cyclin dependent kinase inhibitor 2Aprovided by VGNC
    Primary source
    VGNC:VGNC:109332
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    p16; INK4a; p14ARF; p16INK4A
    Annotation information
    Annotation category: not annotated on reference assembly
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    Genomic context

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    See CDKN2A in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 11 NC_049232.1 (41337054..41366301, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 11 NC_049271.1 (40835885..40865099, complement)

    Chromosome 11 - NC_049271.1Genomic Context describing neighboring genes Neighboring gene methylthioadenosine phosphorylase Neighboring gene uncharacterized LOC119873924 Neighboring gene uncharacterized LOC111098066 Neighboring gene uncharacterized LOC119873925 Neighboring gene uncharacterized LOC102153066 Neighboring gene cyclin dependent kinase inhibitor 2B

    Chromosome 11 - NC_049232.1Genomic Context describing neighboring genes Neighboring gene methylthioadenosine phosphorylase Neighboring gene uncharacterized LOC119873924 Neighboring gene uncharacterized LOC111098066 Neighboring gene uncharacterized LOC119873925 Neighboring gene uncharacterized LOC102153066 Neighboring gene cyclin dependent kinase inhibitor 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Frequent genetic defects in the p16/INK4A tumor suppressor in canine cell models of breast cancer and melanoma. Lutful Kabir FM, et al. In Vitro Cell Dev Biol Anim, 2021 May. PMID 34014456
    2. Identification of common predisposing loci to hematopoietic cancers in four dog breeds. Hédan B, et al. PLoS Genet, 2021 Apr. PMID 33793571, Free PMC Article
    3. Inhibition of p16 tumor suppressor gene expression via promoter hypermethylation in canine lymphoid tumor cells. Fujiwara-Igarashi A, et al. Res Vet Sci, 2014 Aug. PMID 24815345
    4. Novel frameshift mutation in the p16/INK4A tumor suppressor gene in canine breast cancer alters expression from the p16/INK4A/p14ARF locus. Lutful Kabir FM, et al. J Cell Biochem, 2013 Jan. PMID 22833492
    5. The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer. Shearin AL, et al. Cancer Epidemiol Biomarkers Prev, 2012 Jul. PMID 22623710, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genome-Wide Analyses for Osteosarcoma in Leonberger Dogs Reveal the CDKN2A/B Gene Locus as a Major Risk Locus.
      Title: Genome-Wide Analyses for Osteosarcoma in Leonberger Dogs Reveal the CDKN2A/B Gene Locus as a Major Risk Locus.
    2. Frequent genetic defects in the p16/INK4A tumor suppressor in canine cell models of breast cancer and melanoma.
      Title: Frequent genetic defects in the p16/INK4A tumor suppressor in canine cell models of breast cancer and melanoma.
    3. Identification of common predisposing loci to hematopoietic cancers in four dog breeds.
      Title: Identification of common predisposing loci to hematopoietic cancers in four dog breeds.
    4. 14-3-3sigma protein may be an alternative binding partner for p16 active during cell quiescence and may associate with p16 during cell differentiation.
      Title: Evaluation of 14-3-3 sigma as a potential partner of p16 in quiescence and differentiation.
    5. no significant difference in expression between human papillomavirus-positive and -negative Bowen disease
      Title: Human papillomavirus infection in Bowen disease: negative p53 expression, not p16(INK4a) overexpression, is correlated with human papillomavirus-associated Bowen disease.
    6. This study revealed the inactivation of p16 gene through hypermethylation of its CpG island in a fraction of canine lymphoid tumor cells.
      Title: Inhibition of p16 tumor suppressor gene expression via promoter hypermethylation in canine lymphoid tumor cells.
    7. The greyhound locus exhibiting the strongest association, located 150 kilobases upstream of the genes CDKN2A/B, is also the most rearranged locus in canine osteosarcoma tumors.
      Title: Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B.
    8. In lipomas, the increase of HMGA2 due to 12q14-15 chromosomal rearrangements is accompanied by an increased expression of p14Arf.
      Title: Permanent activation of HMGA2 in lipomas mimics its temporal physiological activation linked to the gain of adipose tissue.
    9. In this study, the full-length complementary DNA (cDNA) of the canine p16 gene was cloned using the 5' and 3' rapid amplification of cDNA ends methods.
      Title: Simultaneous inactivation of the p16, p15 and p14 genes encoding cyclin-dependent kinase inhibitors in canine T-lymphoid tumor cells.
    10. Novel frameshift mutation in the p16/INK4A tumor suppressor gene is described in canine breast cancer that alters expression from the p16/INK4A/p14ARF locus.
      Title: Novel frameshift mutation in the p16/INK4A tumor suppressor gene in canine breast cancer alters expression from the p16/INK4A/p14ARF locus.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A
    Names
    cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
    p16/INK4A cyclin-dependent kinase inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049271.1 Alternate UMICH_Zoey_3.1

      Range
      40835885..40865099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038490416.1 → XP_038346344.1  cyclin-dependent kinase inhibitor 2A isoform X1

      Conserved Domains (2) summary
      COG0666
      Location:8 → 115
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:36 → 66
      ANK; ANK repeat [structural motif]

    2. XM_038490417.1 → XP_038346345.1  cyclin-dependent kinase inhibitor 2A isoform X2

      Conserved Domains (2) summary
      COG0666
      Location:18 → 110
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:42 → 73
      ANK; ANK repeat [structural motif]

    3. XM_038490420.1 → XP_038346348.1  cyclin-dependent kinase inhibitor 2A isoform X3

      Conserved Domains (2) summary
      COG0666
      Location:2 → 72
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:25 → 57
      ANK; ANK repeat [structural motif]

    4. XM_038490418.1 → XP_038346346.1  cyclin-dependent kinase inhibitor 2A isoform X3

      Conserved Domains (2) summary
      COG0666
      Location:2 → 72
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:25 → 57
      ANK; ANK repeat [structural motif]

    5. XM_038490419.1 → XP_038346347.1  cyclin-dependent kinase inhibitor 2A isoform X3

      Conserved Domains (2) summary
      COG0666
      Location:2 → 72
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:25 → 57
      ANK; ANK repeat [structural motif]

    6. XM_038490421.1 → XP_038346349.1  cyclin-dependent kinase inhibitor 2A isoform X4

      Conserved Domains (2) summary
      COG0666
      Location:8 → 115
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:36 → 66
      ANK; ANK repeat [structural motif]

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049232.1 Alternate UU_Cfam_GSD_1.0

      Range
      41337054..41366301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038552530.1 → XP_038408458.1  cyclin-dependent kinase inhibitor 2A isoform X1

      UniProtKB/TrEMBL
      I6Q2X5, K7YN73
      Conserved Domains (2) summary
      COG0666
      Location:8 → 115
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:36 → 66
      ANK; ANK repeat [structural motif]

    2. XM_038552531.1 → XP_038408459.1  cyclin-dependent kinase inhibitor 2A isoform X2

      Conserved Domains (2) summary
      COG0666
      Location:18 → 110
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:42 → 73
      ANK; ANK repeat [structural motif]

    3. XM_038552534.1 → XP_038408462.1  cyclin-dependent kinase inhibitor 2A isoform X3

      Conserved Domains (2) summary
      COG0666
      Location:2 → 72
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:25 → 57
      ANK; ANK repeat [structural motif]

    4. XM_038552532.1 → XP_038408460.1  cyclin-dependent kinase inhibitor 2A isoform X3

      Conserved Domains (2) summary
      COG0666
      Location:2 → 72
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:25 → 57
      ANK; ANK repeat [structural motif]

    5. XM_038552533.1 → XP_038408461.1  cyclin-dependent kinase inhibitor 2A isoform X3

      Conserved Domains (2) summary
      COG0666
      Location:2 → 72
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:25 → 57
      ANK; ANK repeat [structural motif]

    6. XM_038552535.1 → XP_038408463.1  cyclin-dependent kinase inhibitor 2A isoform X4

      UniProtKB/TrEMBL
      A0A8C0MZM8, A0A8P0TTY2
      Conserved Domains (2) summary
      COG0666
      Location:8 → 115
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:36 → 66
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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