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    SSBP2 single stranded DNA binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 23635, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SSBP2provided by HGNC
    Official Full Name
    single stranded DNA binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:15831
    See related
    Ensembl:ENSG00000145687 MIM:607389; AllianceGenome:HGNC:15831
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSPC116; SOSS-B2
    Summary
    This gene encodes a subunit of a protein complex that interacts with single-stranded DNA and is involved in the DNA damage response and maintenance of genome stability. The encoded protein may also play a role in telomere repair. A variant of this gene may be associated with survival in human glioblastoma patients. [provided by RefSeq, Sep 2016]
    Expression
    Ubiquitous expression in ovary (RPKM 6.2), brain (RPKM 5.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SSBP2 in Genome Data Viewer
    Location:
    5q14.1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (81412804..81751807, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (81897401..82236409, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (80708623..81047626, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CKMT2 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:80564272-80565471 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:80565548-80566100 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:80566101-80566651 Neighboring gene MPRA-validated peak5313 silencer Neighboring gene creatine kinase, mitochondrial 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:80597135-80597924 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:80597925-80598714 Neighboring gene zinc finger CCHC-type containing 9 Neighboring gene acyl-CoA thioesterase 12 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:80728863-80729548 Neighboring gene NANOG hESC enhancer GRCh37_chr5:80746651-80747152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16141 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:80983594-80984094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16143 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16146 Neighboring gene CRISPRi-validated cis-regulatory element chr5.2009 Neighboring gene CRISPRi-validated cis-regulatory element chr5.2010 Neighboring gene uncharacterized LOC107986384 Neighboring gene uncharacterized LOC107986385 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22733

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Cigarette smoke induces promoter methylation of single-stranded DNA-binding protein 2 in human esophageal squamous cell carcinoma. Huang Y, et al. Int J Cancer, 2011 May 15. PMID 20658532, Free PMC Article
    2. SSBP2, a candidate tumor suppressor gene, induces growth arrest and differentiation of myeloid leukemia cells. Liang H, et al. Oncogene, 2005 Apr 14. PMID 15782145
    3. SSBP2 variants are associated with survival in glioblastoma patients. Xiao Y, et al. Clin Cancer Res, 2012 Jun 1. PMID 22472174, Free PMC Article
    4. Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes. Fleisig HB, et al. Oncogene, 2007 Jul 19. PMID 17311003
    5. Novel SSBP2-JAK2 fusion gene resulting from a t(5;9)(q14.1;p24.1) in pre-B acute lymphocytic leukemia. Poitras JL, et al. Genes Chromosomes Cancer, 2008 Oct. PMID 18618714

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SSBP2-CSF1R is a recurrent fusion in B-lineage acute lymphoblastic leukemia with diverse genetic presentation and variable outcome.
      Title: SSBP2-CSF1R is a recurrent fusion in B-lineage acute lymphoblastic leukemia with diverse genetic presentation and variable outcome.
    2. The structural details of the interaction of single-stranded DNA binding protein hSSB2 (NABP1/OBFC2A) with UV-damaged DNA.
      Title: The structural details of the interaction of single-stranded DNA binding protein hSSB2 (NABP1/OBFC2A) with UV-damaged DNA.
    3. CcRCC with low SSBP2 expression was associated with adverse clinicopathological characteristics and poor patient outcomes.
      Title: Low Expression of Single-stranded DNA Binding Protein 2 (SSBP2) Predicts Unfavourable Postoperative Outcomes in Patients With Clear Cell Renal Cell Carcinoma.
    4. Single-stranded DNA binding proteins (SSBPs) interact specifically with the LDB/Chip conserved domain (LCCD) of LDB proteins and stabilize LDBs by preventing their proteasomal degradation, thus promoting their functions in gene regulation.
      Title: Crystal structure of human LDB1 in complex with SSBP2.
    5. This study reports a crystal structure of the highly conserved N-terminal LUFS domain of human SSBP2 at 1.52 A resolution.
      Title: Crystal structure of the LUFS domain of human single-stranded DNA binding Protein 2 (SSBP2).
    6. SSBP-2-positive hepatocellular carcinomas were significantly associated with aggressive phenotypes and poor clinical outcome.
      Title: Single-stranded DNA binding protein 2 expression is associated with patient survival in hepatocellular carcinoma.
    7. The minor allele of SSBP2 SNP rs17296479 and the increased tumor expression of SSBP2 were statistically significantly associated with poorer overall survival among glioblastoma patients
      Title: SSBP2 variants are associated with survival in glioblastoma patients.
    8. results indicate that cigarette smoking is a cause of SSBP2 promoter methylation and that SSBP2 harbors a tumor suppressive role in ESCC through inhibition of the Wnt signaling pathway
      Title: Cigarette smoke induces promoter methylation of single-stranded DNA-binding protein 2 in human esophageal squamous cell carcinoma.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. ZNF198-FGFR1 is associated with phosphorylation of several proteins including SSBP2, ABL, FLJ14235, CALM and TRIM4 proteins.
      Title: Phosphorylation of the SSBP2 and ABL proteins by the ZNF198-FGFR1 fusion kinase seen in atypical myeloproliferative disorders as revealed by phosphopeptide-specific MS.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.
    EBI GWAS Catalog
    SSBP2 variants are associated with survival in glioblastoma patients.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686F03273

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    single-stranded DNA-binding protein 2
    Names
    sequence-specific single-stranded-DNA-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051589.1 RefSeqGene

      Range
      5157..343450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256732.3 → NP_001243661.1  single-stranded DNA-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001243661.1

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      Consensus CDS
      CCDS75268.1
      UniProtKB/TrEMBL
      A0A087X159, B7Z4K7
      Related
      ENSP00000483921.1, ENST00000615665.5
      Conserved Domains (2) summary
      smart00667
      Location:19 → 45
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:83 → 346
      SSDP; Single-stranded DNA binding protein, SSDP

    2. NM_001256733.3 → NP_001243662.1  single-stranded DNA-binding protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001243662.1

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      Consensus CDS
      CCDS58963.1
      UniProtKB/TrEMBL
      B7Z4K7
      Related
      ENSP00000423969.1, ENST00000505980.5
      Conserved Domains (2) summary
      smart00667
      Location:19 → 45
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:83 → 318
      SSDP; Single-stranded DNA binding protein, SSDP

    3. NM_001256734.3 → NP_001243663.1  single-stranded DNA-binding protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001243663.1

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      Consensus CDS
      CCDS58962.1
      UniProtKB/TrEMBL
      B7Z4K7
      Related
      ENSP00000424657.1, ENST00000515395.5
      Conserved Domains (2) summary
      smart00667
      Location:19 → 45
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:92 → 316
      SSDP; Single-stranded DNA binding protein, SSDP

    4. NM_001256735.3 → NP_001243664.1  single-stranded DNA-binding protein 2 isoform 5

      See identical proteins and their annotated locations for NP_001243664.1

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      Consensus CDS
      CCDS58961.1
      UniProtKB/TrEMBL
      B7Z4K7
      Related
      ENSP00000426183.1, ENST00000514493.5
      Conserved Domains (2) summary
      smart00667
      Location:19 → 45
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:92 → 308
      SSDP; Single-stranded DNA binding protein, SSDP

    5. NM_001256736.3 → NP_001243665.1  single-stranded DNA-binding protein 2 isoform 6

      See identical proteins and their annotated locations for NP_001243665.1

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      Consensus CDS
      CCDS58960.1
      UniProtKB/TrEMBL
      B7Z4K7
      Related
      ENSP00000422961.1, ENST00000509053.5
      Conserved Domains (2) summary
      smart00667
      Location:19 → 45
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:92 → 297
      SSDP; Single-stranded DNA binding protein, SSDP

    6. NM_001345886.2 → NP_001332815.1  single-stranded DNA-binding protein 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7
      Conserved Domains (2) summary
      smart00667
      Location:19 → 45
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:83 → 335
      SSDP; Single-stranded DNA binding protein, SSDP

    7. NM_001394350.1 → NP_001381279.1  single-stranded DNA-binding protein 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7
      Conserved Domains (1) summary
      smart00667
      Location:19 → 45
      LisH; Lissencephaly type-1-like homology motif

    8. NM_001394351.1 → NP_001381280.1  single-stranded DNA-binding protein 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      Q9P038
      Conserved Domains (1) summary
      pfam04503
      Location:79 → 334
      SSDP; Single-stranded DNA binding protein, SSDP

    9. NM_001394352.1 → NP_001381281.1  single-stranded DNA-binding protein 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7
      Conserved Domains (2) summary
      smart00667
      Location:19 → 45
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:83 → 327
      SSDP; Single-stranded DNA binding protein, SSDP

    10. NM_001400340.1 → NP_001387269.1  single-stranded DNA-binding protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      Consensus CDS
      CCDS75268.1
      UniProtKB/TrEMBL
      A0A087X159, B7Z4K7

    11. NM_001400341.1 → NP_001387270.1  single-stranded DNA-binding protein 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    12. NM_001400342.1 → NP_001387271.1  single-stranded DNA-binding protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      Consensus CDS
      CCDS4056.1
      UniProtKB/Swiss-Prot
      B2R5W1, B7Z1J2, B7Z2L9, B7Z665, D6RH18, E9PB74, E9PDA8, P81877, Q8N2Q2, Q9BWW6, Q9Y4T7
      UniProtKB/TrEMBL
      B7Z4K7

    13. NM_001400343.1 → NP_001387272.1  single-stranded DNA-binding protein 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    14. NM_001400344.1 → NP_001387273.1  single-stranded DNA-binding protein 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    15. NM_001400345.1 → NP_001387274.1  single-stranded DNA-binding protein 2 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    16. NM_001400346.1 → NP_001387275.1  single-stranded DNA-binding protein 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    17. NM_001400347.1 → NP_001387276.1  single-stranded DNA-binding protein 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    18. NM_001400348.1 → NP_001387277.1  single-stranded DNA-binding protein 2 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    19. NM_001400349.1 → NP_001387278.1  single-stranded DNA-binding protein 2 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    20. NM_001400350.1 → NP_001387279.1  single-stranded DNA-binding protein 2 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    21. NM_001400351.1 → NP_001387280.1  single-stranded DNA-binding protein 2 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419
      UniProtKB/TrEMBL
      H0Y9M5

    22. NM_001400352.1 → NP_001387281.1  single-stranded DNA-binding protein 2 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    23. NM_001400353.1 → NP_001387282.1  single-stranded DNA-binding protein 2 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    24. NM_001400354.1 → NP_001387283.1  single-stranded DNA-binding protein 2 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    25. NM_001400355.1 → NP_001387284.1  single-stranded DNA-binding protein 2 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    26. NM_001400356.1 → NP_001387285.1  single-stranded DNA-binding protein 2 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      H0Y9M5

    27. NM_001400357.1 → NP_001387286.1  single-stranded DNA-binding protein 2 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    28. NM_001400358.1 → NP_001387287.1  single-stranded DNA-binding protein 2 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    29. NM_001400359.1 → NP_001387288.1  single-stranded DNA-binding protein 2 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419
      UniProtKB/TrEMBL
      B7Z4K7

    30. NM_001400360.1 → NP_001387289.1  single-stranded DNA-binding protein 2 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      H0Y9M5
      Related
      ENSP00000425146.1, ENST00000504985.5

    31. NM_001400361.1 → NP_001387290.1  single-stranded DNA-binding protein 2 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      H0Y9M5

    32. NM_001400362.1 → NP_001387291.1  single-stranded DNA-binding protein 2 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      H0Y9M5

    33. NM_001400363.1 → NP_001387292.1  single-stranded DNA-binding protein 2 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      H0Y9M5
      Related
      ENSP00000424561.1, ENST00000512923.5

    34. NM_001400364.1 → NP_001387293.1  single-stranded DNA-binding protein 2 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419

    35. NM_001400366.1 → NP_001387295.1  single-stranded DNA-binding protein 2 isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    36. NM_001400367.1 → NP_001387296.1  single-stranded DNA-binding protein 2 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      H0Y9M5

    37. NM_001400368.1 → NP_001387297.1  single-stranded DNA-binding protein 2 isoform 34

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      H0Y9M5

    38. NM_001400369.1 → NP_001387298.1  single-stranded DNA-binding protein 2 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    39. NM_001400371.1 → NP_001387300.1  single-stranded DNA-binding protein 2 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      H0Y9M5

    40. NM_001400374.1 → NP_001387303.1  single-stranded DNA-binding protein 2 isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      Q9P038

    41. NM_001400375.1 → NP_001387304.1  single-stranded DNA-binding protein 2 isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      UniProtKB/TrEMBL
      B7Z4K7

    42. NM_012446.5 → NP_036578.2  single-stranded DNA-binding protein 2 isoform 2

      See identical proteins and their annotated locations for NP_036578.2

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250
      Consensus CDS
      CCDS4056.1
      UniProtKB/Swiss-Prot
      B2R5W1, B7Z1J2, B7Z2L9, B7Z665, D6RH18, E9PB74, E9PDA8, P81877, Q8N2Q2, Q9BWW6, Q9Y4T7
      UniProtKB/TrEMBL
      B7Z4K7
      Related
      ENSP00000322977.4, ENST00000320672.9
      Conserved Domains (2) summary
      smart00667
      Location:19 → 45
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:83 → 338
      SSDP; Single-stranded DNA binding protein, SSDP

    RNA

    1. NR_174525.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    2. NR_174526.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    3. NR_174527.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    4. NR_174528.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC093250

    5. NR_174529.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    6. NR_174530.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    7. NR_174531.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    8. NR_174532.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    9. NR_174533.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    10. NR_174534.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    11. NR_174535.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    12. NR_174536.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    13. NR_174537.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    14. NR_174538.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    15. NR_174539.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419

    16. NR_174540.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    17. NR_174541.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    18. NR_174542.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    19. NR_174543.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    20. NR_174544.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    21. NR_174545.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    22. NR_174546.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    23. NR_174547.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    24. NR_174548.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    25. NR_174549.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    26. NR_174550.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    27. NR_174551.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    28. NR_174552.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    29. NR_174553.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    30. NR_174554.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    31. NR_174555.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    32. NR_174556.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    33. NR_174557.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    34. NR_174558.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    35. NR_174559.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419

    36. NR_174560.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    37. NR_174561.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    38. NR_174562.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    39. NR_174563.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010623, AC016562, AC026419, AC093250

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      81412804..81751807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417066.1 → XP_047273022.1  single-stranded DNA-binding protein 2 isoform X5

      UniProtKB/TrEMBL
      H0Y9M5

    2. XM_047417062.1 → XP_047273018.1  single-stranded DNA-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      H0Y9M5

    3. XM_047417061.1 → XP_047273017.1  single-stranded DNA-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      H0Y9M5

    4. XM_047417060.1 → XP_047273016.1  single-stranded DNA-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      B7Z4K7

    5. XM_047417058.1 → XP_047273014.1  single-stranded DNA-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      Q9P038

    6. XM_047417065.1 → XP_047273021.1  single-stranded DNA-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      H0Y9M5

    7. XM_047417059.1 → XP_047273015.1  single-stranded DNA-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      Q9P038

    8. XM_017009309.2 → XP_016864798.1  single-stranded DNA-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      H0Y9M5
      Conserved Domains (1) summary
      pfam04503
      Location:12 → 234
      SSDP; Single-stranded DNA binding protein, SSDP

    9. XM_017009308.2 → XP_016864797.1  single-stranded DNA-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      H0Y9M5
      Conserved Domains (1) summary
      pfam04503
      Location:12 → 234
      SSDP; Single-stranded DNA binding protein, SSDP

    10. XM_047417064.1 → XP_047273020.1  single-stranded DNA-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      H0Y9M5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      81897401..82236409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352278.1 → XP_054208253.1  single-stranded DNA-binding protein 2 isoform X5

      UniProtKB/TrEMBL
      H0Y9M5

    2. XM_054352274.1 → XP_054208249.1  single-stranded DNA-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      H0Y9M5

    3. XM_054352273.1 → XP_054208248.1  single-stranded DNA-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      H0Y9M5

    4. XM_054352272.1 → XP_054208247.1  single-stranded DNA-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      B7Z4K7

    5. XM_054352271.1 → XP_054208246.1  single-stranded DNA-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      Q9P038

    6. XM_054352275.1 → XP_054208250.1  single-stranded DNA-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      H0Y9M5

    7. XM_054352277.1 → XP_054208252.1  single-stranded DNA-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      H0Y9M5

    8. XM_054352276.1 → XP_054208251.1  single-stranded DNA-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      H0Y9M5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P81877.2 GenPept UniProtKB/Swiss-Prot:P81877

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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