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    USP28 ubiquitin specific peptidase 28 [ Homo sapiens (human) ]

    Gene ID: 57646, updated on 10-Dec-2024

    Summary

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    Official Symbol
    USP28provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 28provided by HGNC
    Primary source
    HGNC:HGNC:12625
    See related
    Ensembl:ENSG00000048028 MIM:610748; AllianceGenome:HGNC:12625
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016]
    Expression
    Ubiquitous expression in heart (RPKM 11.8), lymph node (RPKM 4.2) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See USP28 in Genome Data Viewer
    Location:
    11q23.2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (113797875..113875572, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (113808211..113885899, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (113668597..113746294, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37 member A13, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3911 Neighboring gene activating transcription factor 4 pseudogene 4 Neighboring gene ISG20L2 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:113720382-113720923 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:113720924-113721464 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:113721465-113722005 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:113722006-113722545 Neighboring gene RNA, U6 small nuclear 1107, pseudogene Neighboring gene U7 small nuclear RNA Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:113744182-113744682 Neighboring gene Sharpr-MPRA regulatory region 42 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:113746853-113747514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5543 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:113752951-113753737 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:113756096-113756882 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:113766496-113766696 Neighboring gene 5-hydroxytryptamine receptor 3B Neighboring gene ReSE screen-validated silencer GRCh37_chr11:113813804-113813933 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:113822687-113823240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113827432-113828317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113835585-113836084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113845393-113846054 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113846055-113846714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113859815-113860316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113860317-113860816 Neighboring gene 5-hydroxytryptamine receptor 3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K. Prieto-Garcia C, et al. Mol Oncol, 2022 Sep. PMID 35364627, Free PMC Article
    2. USP28 regulates deubiquitination of histone H2A and cell proliferation. Li F, et al. Exp Cell Res, 2019 Jun 1. PMID 30910399
    3. Knockdown of USP28 enhances the radiosensitivity of esophageal cancer cells via the c-Myc/hypoxia-inducible factor-1 alpha pathway. Weili Z, et al. J Cell Biochem, 2019 Jan. PMID 30206969
    4. Comprehensive prognostic and immunological analysis of Ubiquitin Specific Peptidase 28 in pan-cancers and identification of its role in hepatocellular carcinoma cell lines. Zhou W, et al. Aging (Albany NY), 2023 Jul 13. PMID 37450415, Free PMC Article
    5. USP28 is a potential prognostic marker for bladder cancer. Guo G, et al. Tumour Biol, 2014 May. PMID 24347490

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage.
      Title: The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage.
    2. Control of cell proliferation by memories of mitosis.
      Title: Control of cell proliferation by memories of mitosis.
    3. USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells.
      Title: USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells.
    4. The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cells.
      Title: The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cells.
    5. Comprehensive prognostic and immunological analysis of Ubiquitin Specific Peptidase 28 in pan-cancers and identification of its role in hepatocellular carcinoma cell lines.
      Title: Comprehensive prognostic and immunological analysis of Ubiquitin Specific Peptidase 28 in pan-cancers and identification of its role in hepatocellular carcinoma cell lines.
    6. Inhibition of deubiquitinase USP28 attenuates cyst growth in autosomal dominant polycystic kidney disease.
      Title: Inhibition of deubiquitinase USP28 attenuates cyst growth in autosomal dominant polycystic kidney disease.
    7. USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K.
      Title: USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K.
    8. The deubiquitinase USP28 stabilizes the expression of RecQ family helicases and maintains the viability of triple negative breast cancer cells.
      Title: The deubiquitinase USP28 stabilizes the expression of RecQ family helicases and maintains the viability of triple negative breast cancer cells.
    9. Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling.
      Title: Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling.
    10. USP28 promotes aerobic glycolysis of colorectal cancer by increasing stability of FOXC1.
      Title: USP28 promotes aerobic glycolysis of colorectal cancer by increasing stability of FOXC1.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • KIAA1515

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to UV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deubiquitination TAS
    Traceable Author Statement
    more info
    		  
    involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ionizing radiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 28
    Names
    deubiquitinating enzyme 28
    ubiquitin thioesterase 28
    ubiquitin thiolesterase 28
    ubiquitin-specific-processing protease 28
    NP_001287958.1
    NP_001333181.1
    NP_001333182.1
    NP_001333183.1
    NP_001333184.1
    NP_001333186.1
    NP_001333187.1
    NP_001333188.1
    NP_001333189.1
    NP_001333190.1
    NP_001333191.1
    NP_001333192.1
    NP_001333193.1
    NP_001333194.1
    NP_001333196.1
    NP_001333197.1
    NP_001333198.1
    NP_001333199.1
    NP_001333200.1
    NP_001333201.1
    NP_001333202.1
    NP_001387713.1
    NP_001387714.1
    NP_001387715.1
    NP_001387716.1
    NP_001387717.1
    NP_001387718.1
    NP_001387719.1
    NP_001387720.1
    NP_001387721.1
    NP_001387722.1
    NP_001387723.1
    NP_001387724.1
    NP_001387725.1
    NP_001387726.1
    NP_001387728.1
    NP_001387729.1
    NP_001387730.1
    NP_001387731.1
    NP_001387732.1
    NP_001387733.1
    NP_001387734.1
    NP_001387735.1
    NP_001387736.1
    NP_001387738.1
    NP_001387739.1
    NP_001387740.1
    NP_001387741.1
    NP_001387742.1
    NP_065937.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051668.1 RefSeqGene

      Range
      4999..82696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001301029.2 → NP_001287958.1  ubiquitin carboxyl-terminal hydrolase 28 isoform b

      See identical proteins and their annotated locations for NP_001287958.1

      Status: REVIEWED

      Source sequence(s)
      AK304770, AP001874, AP003170, BC035986, BF434481, DB061316
      Consensus CDS
      CCDS73394.1
      UniProtKB/TrEMBL
      B4E3L3, G3V1N5
      Related
      ENSP00000444991.1, ENST00000545540.5
      Conserved Domains (3) summary
      cd02665
      Location:38 → 523
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:38 → 142
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:36 → 273
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. NM_001346252.4 → NP_001333181.1  ubiquitin carboxyl-terminal hydrolase 28 isoform c

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      Consensus CDS
      CCDS91596.1
      UniProtKB/TrEMBL
      A0A8V8TLZ9
      Related
      ENSP00000513009.1, ENST00000696973.1

    3. NM_001346253.2 → NP_001333182.1  ubiquitin carboxyl-terminal hydrolase 28 isoform d

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    4. NM_001346254.2 → NP_001333183.1  ubiquitin carboxyl-terminal hydrolase 28 isoform e

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    5. NM_001346255.2 → NP_001333184.1  ubiquitin carboxyl-terminal hydrolase 28 isoform f

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    6. NM_001346257.2 → NP_001333186.1  ubiquitin carboxyl-terminal hydrolase 28 isoform g

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    7. NM_001346258.2 → NP_001333187.1  ubiquitin carboxyl-terminal hydrolase 28 isoform h

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/Swiss-Prot
      Q96RU2

    8. NM_001346259.2 → NP_001333188.1  ubiquitin carboxyl-terminal hydrolase 28 isoform i

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      Conserved Domains (3) summary
      COG5207
      Location:136 → 608
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02665
      Location:137 → 622
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd20487
      Location:740 → 1019
      USP28_C; carboxyl-terminal domain of ubiquitin-specific protease 28 (USP28)

    9. NM_001346260.2 → NP_001333189.1  ubiquitin carboxyl-terminal hydrolase 28 isoform j

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    10. NM_001346261.2 → NP_001333190.1  ubiquitin carboxyl-terminal hydrolase 28 isoform k

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    11. NM_001346262.2 → NP_001333191.1  ubiquitin carboxyl-terminal hydrolase 28 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variant 2, encodes isoform b.
      Source sequence(s)
      AP001874, AP003170, KF459544
      Consensus CDS
      CCDS73394.1
      UniProtKB/TrEMBL
      B4E3L3, G3V1N5

    12. NM_001346263.2 → NP_001333192.1  ubiquitin carboxyl-terminal hydrolase 28 isoform l

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    13. NM_001346264.2 → NP_001333193.1  ubiquitin carboxyl-terminal hydrolase 28 isoform m

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    14. NM_001346265.2 → NP_001333194.1  ubiquitin carboxyl-terminal hydrolase 28 isoform n

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    15. NM_001346267.2 → NP_001333196.1  ubiquitin carboxyl-terminal hydrolase 28 isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variant 17, encodes isoform o.
      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    16. NM_001346268.2 → NP_001333197.1  ubiquitin carboxyl-terminal hydrolase 28 isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variant 16, encodes isoform o.
      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    17. NM_001346269.2 → NP_001333198.1  ubiquitin carboxyl-terminal hydrolase 28 isoform p

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 19 and 20, encodes isoform p.
      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    18. NM_001346270.2 → NP_001333199.1  ubiquitin carboxyl-terminal hydrolase 28 isoform p

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 18 and 20, encodes isoform p.
      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    19. NM_001346271.2 → NP_001333200.1  ubiquitin carboxyl-terminal hydrolase 28 isoform p

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 18 and 19, encodes isoform p.
      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    20. NM_001346272.2 → NP_001333201.1  ubiquitin carboxyl-terminal hydrolase 28 isoform q

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    21. NM_001346273.2 → NP_001333202.1  ubiquitin carboxyl-terminal hydrolase 28 isoform r

      Status: REVIEWED

      Source sequence(s)
      AP001874, BC065928, DB061316
      Consensus CDS
      CCDS86248.1
      UniProtKB/Swiss-Prot
      Q96RU2
      Related
      ENSP00000445743.1, ENST00000537706.5
      Conserved Domains (3) summary
      cd02665
      Location:163 → 397
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14355
      Location:23 → 64
      UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
      cl02553
      Location:163 → 267
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    22. NM_001400784.1 → NP_001387713.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    23. NM_001400785.1 → NP_001387714.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    24. NM_001400786.1 → NP_001387715.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    25. NM_001400787.1 → NP_001387716.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    26. NM_001400788.1 → NP_001387717.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    27. NM_001400789.1 → NP_001387718.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    28. NM_001400790.1 → NP_001387719.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    29. NM_001400791.1 → NP_001387720.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    30. NM_001400792.1 → NP_001387721.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    31. NM_001400793.1 → NP_001387722.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    32. NM_001400794.1 → NP_001387723.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170

    33. NM_001400795.1 → NP_001387724.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    34. NM_001400796.1 → NP_001387725.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    35. NM_001400797.1 → NP_001387726.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    36. NM_001400799.1 → NP_001387728.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 34

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    37. NM_001400800.1 → NP_001387729.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    38. NM_001400801.1 → NP_001387730.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5
      Related
      ENSP00000442431.1, ENST00000544967.5

    39. NM_001400802.1 → NP_001387731.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    40. NM_001400803.1 → NP_001387732.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    41. NM_001400804.1 → NP_001387733.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    42. NM_001400805.1 → NP_001387734.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 38

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    43. NM_001400806.1 → NP_001387735.1  ubiquitin carboxyl-terminal hydrolase 28 isoform q

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    44. NM_001400807.1 → NP_001387736.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    45. NM_001400809.1 → NP_001387738.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 40

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    46. NM_001400810.1 → NP_001387739.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 41

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    47. NM_001400811.1 → NP_001387740.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    48. NM_001400812.1 → NP_001387741.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 42

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    49. NM_001400813.1 → NP_001387742.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      G3V1N5

    50. NM_020886.4 → NP_065937.1  ubiquitin carboxyl-terminal hydrolase 28 isoform a

      See identical proteins and their annotated locations for NP_065937.1

      Status: REVIEWED

      Source sequence(s)
      AF266283, AP001874, AP003170, BC035986, BF434481, DB061316
      Consensus CDS
      CCDS31680.1
      UniProtKB/Swiss-Prot
      B0YJC0, B0YJC1, Q6NZX9, Q96RU2, Q9P213
      Related
      ENSP00000003302.4, ENST00000003302.8
      Conserved Domains (4) summary
      cd02665
      Location:163 → 648
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14355
      Location:23 → 64
      UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
      cl02553
      Location:163 → 267
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:161 → 398
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RNA

    1. NR_174609.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      113797875..113875572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      113808211..113885899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96RU2.1 GenPept UniProtKB/Swiss-Prot:Q96RU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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