Zw Zwischenferment [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Zwprovided by FlyBase
Official Full Name: Zwischenfermentprovided by FlyBase
Primary source: FLYBASE:FBgn0004057
Locus tag: Dmel_CG12529
See related: AllianceGenome:FB:FBgn0004057
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12529; Dmel\CG12529; G-6-PD; G-6-pdh; G-6pd; G-6PD; G6-pd; G6-PD; g6pd; G6pd; G6PD; G6pdh; G6PDH; zw
Summary: Enables glucose-6-phosphate dehydrogenase activity. Involved in pentose-phosphate shunt, oxidative branch. Predicted to be active in cytosol. Is expressed in adult fat body and adult head. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 18D13-18D13; 1-63 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19667252..19672353)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19561285..19566386)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

glucose-6-phosphate dehydrogenase overexpression extends the life span of Drosophila melanogaster
Title: Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables glucose-6-phosphate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucose-6-phosphate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose-6-phosphate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables glucose-6-phosphate dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in NADP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose 6-phosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt, oxidative branch	IBA Inferred from Biological aspect of Ancestor more info
involved_in pentose-phosphate shunt, oxidative branch	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zwischenferment

Names: CG12529-PA; CG12529-PB; CG12529-PC; Glucose-6-phosphate DH; Zw-PA; Zw-PB; Zw-PC; glucose 6-phosphate dehydrogenase; glucose-6-phosphate 1dehydrogenase; glucose-6-phosphate dehydrogenase; zwishenferment

NP_001285456.1

EC 1.1.-.-

EC 1.1.1.49

NP_523411.1

EC 1.1.-.-

EC 1.1.1.49

NP_728287.1

EC 1.1.-.-

EC 1.1.1.49

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

19667252..19672353

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078687.2 → NP_523411.1 zwischenferment, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523411.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B7FNK0, P12646, Q27574, Q27872, Q27879, Q27881, Q9VWE2, Q9VWE3, X2JEF0

Related

FBpp0074517

Conserved Domains (3) summary

TIGR00871
Location:35 → 498

zwf; glucose-6-phosphate 1-dehydrogenase

pfam00479
Location:39 → 213

G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain

pfam02781
Location:216 → 508

G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain
NM_167676.2 → NP_728287.1 zwischenferment, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728287.1

Status: REVIEWED

Related

FBpp0074518

Conserved Domains (3) summary

TIGR00871
Location:13 → 476

zwf; glucose-6-phosphate 1-dehydrogenase

pfam00479
Location:17 → 191

G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain

pfam02781
Location:194 → 486

G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain
NM_001298527.1 → NP_001285456.1 zwischenferment, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285456.1

Status: REVIEWED

Conserved Domains (3) summary

TIGR00871
Location:13 → 476

zwf; glucose-6-phosphate 1-dehydrogenase

pfam00479
Location:17 → 191

G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain

pfam02781
Location:194 → 486

G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain