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    PRY PTPN13 like Y-linked [ Homo sapiens (human) ]

    Gene ID: 9081, updated on 22-Oct-2024

    Summary

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    Official Symbol
    PRYprovided by HGNC
    Official Full Name
    PTPN13 like Y-linkedprovided by HGNC
    Primary source
    HGNC:HGNC:14024
    See related
    Ensembl:ENSG00000169789 MIM:400019; AllianceGenome:HGNC:14024
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRY1; PTPN13LY
    Summary
    This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. Two nearly identical copies of this gene exist within a palindromic region. This record represents the more telomeric copy. [provided by RefSeq, Aug 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See PRY in Genome Data Viewer
    Location:
    Yq11.223
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (22490397..22514637)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (22907275..22931519, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (24636544..24660784)

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein Y-linked family 1 member J Neighboring gene uncharacterized LOC101929148 Neighboring gene testis expressed transcript, Y-linked 6 Neighboring gene elongin C pseudogene 8 Neighboring gene chromodomain Y-linked 13 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression pattern of the Y-linked PRY gene suggests a function in apoptosis but not in spermatogenesis. Stouffs K, et al. Mol Hum Reprod, 2004 Jan. PMID 14665702
    2. Characterization of the genomic organization, localization and expression of four PRY genes (PRY1, PRY2, PRY3 and PRY4). Stouffs K, et al. Mol Hum Reprod, 2001 Jul. PMID 11420382
    3. A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region. Repping S, et al. Genomics, 2004 Jun. PMID 15177557
    4. Y Chromosome Infertility. Adam MP, et al. , 1993. PMID 20301513
    5. Functional coherence of the human Y chromosome. Lahn BT, et al. Science, 1997 Oct 24. PMID 9381176

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Spermatogenic failure, Y-linked, 2
    MedGen: C1839071 OMIM: 415000 GeneReviews: Y Chromosome Infertility
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • testis-specific PTP-BL-related protein on Y

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_197358.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008175
      Related
      ENST00000303728.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      22490397..22514637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      22907275..22931519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_032916.1: Suppressed sequence

      Description
      NG_032916.1: This RefSeq was removed by NCBI staff.

    2. NM_004676.2: Suppressed sequence

      Description
      NM_004676.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14603.2 GenPept UniProtKB/Swiss-Prot:O14603

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