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    Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 [ Mus musculus (house mouse) ]

    Gene ID: 15486, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hsd17b2provided by MGI
    Official Full Name
    hydroxysteroid (17-beta) dehydrogenase 2provided by MGI
    Primary source
    MGI:MGI:1096386
    See related
    Ensembl:ENSMUSG00000031844 AllianceGenome:MGI:1096386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Acts upstream of or within in utero embryonic development and placenta development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including adrenal gland; genitourinary system; gut; labyrinthine zone; and liver. Orthologous to human HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 84.5), colon adult (RPKM 79.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hsd17b2 in Genome Data Viewer
    Location:
    8 E1; 8 64.82 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (118427752..118485767)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (117700982..117759030)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31717 Neighboring gene predicted gene, 38416 Neighboring gene predicted gene, 31774 Neighboring gene predicted gene, 39261 Neighboring gene STARR-positive B cell enhancer mm9_chr8:120303396-120303696 Neighboring gene STARR-positive B cell enhancer ABC_E9744 Neighboring gene M phase phosphoprotein 6 Neighboring gene STARR-positive B cell enhancer ABC_E1377

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Impaired cortical bone acquisition and osteoblast differentiation in mice with osteoblast-targeted disruption of glucocorticoid signaling. Sher LB, et al. Calcif Tissue Int, 2006 Aug. PMID 16927049
    2. Androgen receptor and 17beta-HSD type 2 regulation in neonatal mouse lung development. Boucher E, et al. Mol Cell Endocrinol, 2009 Nov 13. PMID 19576262
    3. Ontogeny of 17beta-hydroxysteroid dehydrogenase type 2 mRNA expression in the developing mouse placenta and fetus. Mustonen M, et al. Mol Cell Endocrinol, 1997 Oct 31. PMID 9406847
    4. 17Beta-HSD type 5 expression and the emergence of differentiated epithelial Type II cells in fetal lung: a novel role for androgen during the surge of surfactant. Tremblay Y, et al. Mol Cell Endocrinol, 2006 Mar 27. PMID 16337335
    5. Expression of mouse 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase type 7 in the ovary, uterus, and placenta: localization from implantation to late pregnancy. Nokelainen P, et al. Endocrinology, 2000 Feb. PMID 10650959

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results demonstrate temporal and spatial regulation of androgen receptor and 17beta-HSD 2 during the sacculo-alveolar transition period of mouse lung development suggesting control of androgen action.[17beta HSD2]
      Title: Androgen receptor and 17beta-HSD type 2 regulation in neonatal mouse lung development.
    2. HSD17B2 plays a role in the cellular organization of the mouse placenta.
      Title: Placenta defects and embryonic lethality resulting from disruption of mouse hydroxysteroid (17-beta) dehydrogenase 2 gene.
    3. Hsd17b2 has a role in cortical bone acquisition and full osteoblast differentiation
      Title: Impaired cortical bone acquisition and osteoblast differentiation in mice with osteoblast-targeted disruption of glucocorticoid signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables testosterone dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables testosterone dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables testosterone dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in androgen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in androgen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in androgen metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in estrogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in estrogen biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within placenta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    estradiol 17-beta-dehydrogenase 2
    Names
    17 HSD type 2
    17-beta-HSD 2
    17-beta-hydroxysteroid dehydrogenase 2
    17-beta-hydroxysteroid dehydrogenase type 2
    testosterone 17-beta-dehydrogenase
    NP_001411758.1
    NP_032316.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424829.1 → NP_001411758.1  estradiol 17-beta-dehydrogenase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC112964, AC122036

    2. NM_008290.3 → NP_032316.2  estradiol 17-beta-dehydrogenase 2 isoform 1

      See identical proteins and their annotated locations for NP_032316.2

      Status: VALIDATED

      Source sequence(s)
      AC112964, AC122036
      Consensus CDS
      CCDS40491.1
      UniProtKB/Swiss-Prot
      O08898, P51658
      Related
      ENSMUSP00000034304.8, ENSMUST00000034304.9
      Conserved Domains (2) summary
      cd09805
      Location:84 → 364
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
      pfam00106
      Location:84 → 279
      adh_short; short chain dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      118427752..118485767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51658.2 GenPept UniProtKB/Swiss-Prot:P51658

    Gene LinkOut

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