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    DENND2B DENN domain containing 2B [ Gallus gallus (chicken) ]

    Gene ID: 423055, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DENND2Bprovided by CGNC
    Official Full Name
    DENN domain containing 2Bprovided by CGNC
    Primary source
    CGNC:4427
    See related
    Ensembl:ENSGALG00010020602
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    ST5
    Orthologs
    human mouse all
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    Genomic context

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    See DENND2B in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (9252768..9403428)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (9221956..9372725)

    Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene C11orf16 homolog Neighboring gene achaete-scute complex homolog 3 (Drosophila) Neighboring gene A-kinase interacting protein 1 Neighboring gene small nucleolar RNA SNORA3/SNORA45 family Neighboring gene small nucleolar RNA SNORA3/SNORA45 family Neighboring gene ribosomal protein L27a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    suppression of tumorigenicity 5 protein; DENN domain-containing protein 2B
    Names
    suppression of tumorigenicity 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      9252768..9403428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046941985.1 → XP_046797941.1  DENN domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL81

    2. XM_046941986.1 → XP_046797942.1  DENN domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL81

    3. XM_015286487.4 → XP_015141973.2  DENN domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL81
      Conserved Domains (3) summary
      smart00801
      Location:1006 → 1072
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:775 → 958
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:679 → 767
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    4. XM_004941391.5 → XP_004941448.1  DENN domain-containing protein 2B isoform X3

      Conserved Domains (3) summary
      smart00801
      Location:602 → 668
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:275 → 363
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:370 → 551
      DENN; DENN (AEX-3) domain

    5. XM_046941981.1 → XP_046797937.1  DENN domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL81

    6. XM_046941983.1 → XP_046797939.1  DENN domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL81

    7. XM_015286486.4 → XP_015141972.2  DENN domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL81
      Related
      ENSGALP00010029380.1, ENSGALT00010049722.1
      Conserved Domains (3) summary
      smart00801
      Location:1006 → 1072
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:775 → 958
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:679 → 767
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    8. XM_040701334.2 → XP_040557268.1  DENN domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL81
      Conserved Domains (3) summary
      smart00801
      Location:1006 → 1072
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:775 → 958
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:679 → 767
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    9. XM_046941988.1 → XP_046797944.1  DENN domain-containing protein 2B isoform X2

    10. XM_046941980.1 → XP_046797936.1  DENN domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL81

    11. XM_040701337.2 → XP_040557271.1  DENN domain-containing protein 2B isoform X3

      Conserved Domains (3) summary
      smart00801
      Location:602 → 668
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:275 → 363
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:370 → 551
      DENN; DENN (AEX-3) domain

    12. XM_046941989.1 → XP_046797945.1  DENN domain-containing protein 2B isoform X2

    13. XM_420988.7 → XP_420988.3  DENN domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL81
      Conserved Domains (3) summary
      smart00801
      Location:1006 → 1072
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:775 → 958
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:679 → 767
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    14. XM_015286490.4 → XP_015141976.1  DENN domain-containing protein 2B isoform X3

      Conserved Domains (3) summary
      smart00801
      Location:602 → 668
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:275 → 363
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:370 → 551
      DENN; DENN (AEX-3) domain

    15. XM_046941982.1 → XP_046797938.1  DENN domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL81

    16. XM_046941984.1 → XP_046797940.1  DENN domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL81

    17. XM_040701336.2 → XP_040557270.1  DENN domain-containing protein 2B isoform X2

      Conserved Domains (3) summary
      smart00801
      Location:826 → 892
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:595 → 778
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:499 → 587
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    18. XM_004941390.5 → XP_004941447.2  DENN domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL81
      Conserved Domains (3) summary
      smart00801
      Location:1006 → 1072
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:775 → 958
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:679 → 767
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    19. XM_025150880.3 → XP_025006648.1  DENN domain-containing protein 2B isoform X3

      Conserved Domains (3) summary
      smart00801
      Location:602 → 668
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:275 → 363
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:370 → 551
      DENN; DENN (AEX-3) domain

    20. XM_046941979.1 → XP_046797935.1  DENN domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL81

    21. XM_015286489.4 → XP_015141975.2  DENN domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL81
      Conserved Domains (3) summary
      smart00801
      Location:1006 → 1072
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:775 → 958
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:679 → 767
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    22. XM_046941990.1 → XP_046797946.1  DENN domain-containing protein 2B isoform X2

    23. XM_046941992.1 → XP_046797948.1  DENN domain-containing protein 2B isoform X2

    24. XM_046941987.1 → XP_046797943.1  DENN domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL81

    25. XM_040701335.2 → XP_040557269.1  DENN domain-containing protein 2B isoform X2

      Conserved Domains (3) summary
      smart00801
      Location:826 → 892
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:595 → 778
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:499 → 587
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    26. XM_040701339.2 → XP_040557273.1  DENN domain-containing protein 2B isoform X4

      Conserved Domains (3) summary
      smart00801
      Location:494 → 560
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:263 → 446
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:167 → 255
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      9221956..9372725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040673358.2 → XP_040529292.1  DENN domain-containing protein 2B isoform X1

      Conserved Domains (3) summary
      smart00801
      Location:1006 → 1072
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:679 → 767
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:774 → 955
      DENN; DENN (AEX-3) domain

    2. XM_040673365.2 → XP_040529299.1  DENN domain-containing protein 2B isoform X3

      Conserved Domains (3) summary
      smart00801
      Location:602 → 668
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:275 → 363
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:370 → 551
      DENN; DENN (AEX-3) domain

    3. XM_046919469.1 → XP_046775425.1  DENN domain-containing protein 2B isoform X1

    4. XM_046919468.1 → XP_046775424.1  DENN domain-containing protein 2B isoform X1

    5. XM_040673359.2 → XP_040529293.1  DENN domain-containing protein 2B isoform X1

      Conserved Domains (3) summary
      smart00801
      Location:1006 → 1072
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:679 → 767
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:774 → 955
      DENN; DENN (AEX-3) domain

    6. XM_046919472.1 → XP_046775428.1  DENN domain-containing protein 2B isoform X2

    7. XM_040673357.2 → XP_040529291.1  DENN domain-containing protein 2B isoform X1

      Conserved Domains (3) summary
      smart00801
      Location:1006 → 1072
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:679 → 767
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:774 → 955
      DENN; DENN (AEX-3) domain

    8. XM_040673364.2 → XP_040529298.1  DENN domain-containing protein 2B isoform X3

      Conserved Domains (3) summary
      smart00801
      Location:602 → 668
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:275 → 363
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:370 → 551
      DENN; DENN (AEX-3) domain

    9. XM_046919470.1 → XP_046775426.1  DENN domain-containing protein 2B isoform X1

    10. XM_040673363.2 → XP_040529297.1  DENN domain-containing protein 2B isoform X2

      Conserved Domains (3) summary
      smart00801
      Location:826 → 892
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:595 → 778
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:499 → 587
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    11. XM_040673360.2 → XP_040529294.1  DENN domain-containing protein 2B isoform X1

      Conserved Domains (3) summary
      smart00801
      Location:1006 → 1072
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:679 → 767
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:774 → 955
      DENN; DENN (AEX-3) domain

    12. XM_040673366.2 → XP_040529300.1  DENN domain-containing protein 2B isoform X3

      Conserved Domains (3) summary
      smart00801
      Location:602 → 668
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:275 → 363
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:370 → 551
      DENN; DENN (AEX-3) domain

    13. XM_046919467.1 → XP_046775423.1  DENN domain-containing protein 2B isoform X1

    14. XM_040673361.2 → XP_040529295.1  DENN domain-containing protein 2B isoform X1

      Conserved Domains (3) summary
      smart00801
      Location:1006 → 1072
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:679 → 767
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:774 → 955
      DENN; DENN (AEX-3) domain

    15. XM_046919473.1 → XP_046775429.1  DENN domain-containing protein 2B isoform X2

    16. XM_046919474.1 → XP_046775430.1  DENN domain-containing protein 2B isoform X2

    17. XM_046919471.1 → XP_046775427.1  DENN domain-containing protein 2B isoform X1

    18. XM_040673362.2 → XP_040529296.1  DENN domain-containing protein 2B isoform X2

      Conserved Domains (3) summary
      smart00801
      Location:826 → 892
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:595 → 778
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:499 → 587
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    19. XM_040673368.2 → XP_040529302.1  DENN domain-containing protein 2B isoform X4

      Conserved Domains (3) summary
      smart00801
      Location:494 → 560
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:263 → 446
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:167 → 255
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    Nucleotide Protein Strain
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