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    XRCC5 X-ray repair cross complementing 5 [ Gallus gallus (chicken) ]

    Gene ID: 424222, updated on 3-Dec-2024

    Summary

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    Symbol
    XRCC5provided by CGNC
    Full Name
    X-ray repair cross complementing 5provided by CGNC
    Primary source
    CGNC:8733
    See related
    Ensembl:ENSGALG00010021235
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See XRCC5 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (23121282..23165084, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (23040108..23084072, complement)

    Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124418126 Neighboring gene membrane associated ring-CH-type finger 4 Neighboring gene uncharacterized LOC107053887 Neighboring gene transmembrane protein 169 Neighboring gene peroxisomal trans-2-enoyl-CoA reductase Neighboring gene mitogen-activated protein kinase kinase kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation. Abe T, et al. Cell Signal, 2008 Nov. PMID 18674614
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KU70 and DNA-PKcs unexpectedly function together during the induction of apoptosis.
      Title: KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to X-ray IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ku70:Ku80 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    X-ray repair cross-complementing protein 5
    Names
    X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
    X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa)
    XP_040532570.1
    XP_040532571.2
    XP_040559816.2
    XP_046778102.1
    XP_046778103.1
    XP_046799672.1
    XP_046799673.1
    XP_422072.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      23121282..23165084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_422072.8 → XP_422072.5  X-ray repair cross-complementing protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZBK8, A0A8V0ZIP8
      Related
      ENSGALP00010030666.1, ENSGALT00010051475.1
      Conserved Domains (2) summary
      cd00873
      Location:281 → 579
      KU80; Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...
      cl00057
      Location:45 → 209
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. XM_046943716.1 → XP_046799672.1  X-ray repair cross-complementing protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZBK8

    3. XM_046943717.1 → XP_046799673.1  X-ray repair cross-complementing protein 5 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZBK8

    4. XM_040703882.2 → XP_040559816.2  X-ray repair cross-complementing protein 5 isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZBK8

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      23040108..23084072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040676636.2 → XP_040532570.1  X-ray repair cross-complementing protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZBK8
      Conserved Domains (2) summary
      cd00873
      Location:281 → 579
      KU80; Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...
      cl00057
      Location:45 → 209
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. XM_046922146.1 → XP_046778102.1  X-ray repair cross-complementing protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZBK8

    3. XM_046922147.1 → XP_046778103.1  X-ray repair cross-complementing protein 5 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZBK8

    4. XM_040676637.2 → XP_040532571.2  X-ray repair cross-complementing protein 5 isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZBK8
    Nucleotide Protein Strain
    Heading Accession and Version

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