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    RET ret proto-oncogene [ Gallus gallus (chicken) ]

    Gene ID: 396107, updated on 3-Dec-2024

    Summary

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    Symbol
    RETprovided by CGNC
    Full Name
    ret proto-oncogeneprovided by CGNC
    Primary source
    CGNC:1837
    See related
    Ensembl:ENSGALG00010011131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See RET in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (5477834..5584430, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (5364542..5443960, complement)

    Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene RasGEF domain family member 1A Neighboring gene microRNA mir-12280 Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 2 Neighboring gene uncharacterized LOC121111190 Neighboring gene paired box protein 6 homolog Neighboring gene BMS1, ribosome biogenesis factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The receptor tyrosine kinase RET regulates hindgut colonization by sacral neural crest cells. Delalande JM, et al. Dev Biol, 2008 Jan 1. PMID 18031721
    2. Expression of ret in the chicken embryo suggests roles in regionalisation of the vagal neural tube and somites and in development of multiple neural crest and placodal lineages. Robertson K, et al. Mech Dev, 1995 Nov. PMID 8645600
    3. RET overactivation leads to concurrent Hirschsprung disease and intestinal ganglioneuromas. Nagy N, et al. Development, 2020 Nov 5. PMID 32994173, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proto-oncogene tyrosine-protein kinase receptor Ret
    NP_990521.3
    XP_040558213.1
    XP_040558214.1
    XP_040558215.1
    XP_046775888.1
    XP_046775889.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205190.3 → NP_990521.3  proto-oncogene tyrosine-protein kinase receptor Ret precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000227
      UniProtKB/TrEMBL
      Q90601
      Related
      ENSGALP00010015190.1, ENSGALT00010026638.1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      5477834..5584430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040702280.2 → XP_040558214.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform X2

      UniProtKB/TrEMBL
      A0A8V0Y3L0
      Conserved Domains (2) summary
      cd05045
      Location:633 → 922
      PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
      smart00112
      Location:106 → 178
      CA; Cadherin repeats

    2. XM_040702279.2 → XP_040558213.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform X1

      UniProtKB/TrEMBL
      A0A8V0YGR1, Q9PSD4
      Related
      ENSGALP00010015192.1, ENSGALT00010026641.1
      Conserved Domains (3) summary
      cd05045
      Location:714 → 1003
      PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
      cd11304
      Location:26 → 94
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:187 → 259
      CA; Cadherin repeats

    3. XM_040702281.1 → XP_040558215.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform X2

      UniProtKB/TrEMBL
      A0A8V0Y3L0
      Related
      ENSGALP00010015196.1, ENSGALT00010026645.1
      Conserved Domains (2) summary
      cd05045
      Location:633 → 922
      PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
      smart00112
      Location:106 → 178
      CA; Cadherin repeats

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      5364542..5443960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046919932.1 → XP_046775888.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform X1

      UniProtKB/TrEMBL
      Q9PSD4

    2. XM_046919933.1 → XP_046775889.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform X2

      UniProtKB/TrEMBL
      A0A8V0Y3L0
    Nucleotide Protein Strain
    Heading Accession and Version

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