Poldip2 DNA polymerase delta interacting protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Poldip2provided by RGD
Official Full Name: DNA polymerase delta interacting protein 2provided by RGD
Primary source: RGD:1307022
See related: EnsemblRapid:ENSRNOG00000009252 AllianceGenome:RGD:1307022
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PDIP38
Summary: Predicted to enable DNA binding activity. Involved in several processes, including positive regulation of Rho guanyl-nucleotide exchange factor activity; positive regulation of focal adhesion assembly; and vascular associated smooth muscle cell proliferation. Located in cell-cell junction; midbody; and mitotic spindle. Orthologous to human POLDIP2 (DNA polymerase delta interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 735.3), Muscle (RPKM 606.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q25

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (63905287..63915655)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (63407237..63417605)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (65781994..65790833)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZEB1 regulates bone metabolism in osteoporotic rats through inducing POLDIP2 transcription.
Title: ZEB1 regulates bone metabolism in osteoporotic rats through inducing POLDIP2 transcription.
Integrin engagement during cell attachment activates Poldip2/Nox4 to oxidize actin, which modulates filamentous actin assembly and its interaction with vinculin.
Title: NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase δ-Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion.
Endogenous Poldip2 mediates focal adhesion formation via FAK, RhoA, and Nox4.
Title: Poldip2 controls vascular smooth muscle cell migration by regulating focal adhesion turnover and force polarization.
RhoA/ROCK is upstream of Poldip2-dependent Nox4 regulation and ROS production and induces redox signaling of kidney myofibroblast activation and may have broader implications in the pathophysiology of renal fibrosis.
Title: RhoA/Rho kinase mediates TGF-β1-induced kidney myofibroblast activation through Poldip2/Nox4-derived reactive oxygen species.
Poldip2 associates with p22phox to activate Nox4, leading to regulation of focal adhesion turnover and vascular smooth muscle cell migration, thus linking reactive oxygen species production and cytoskeletal remodeling.
Title: Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells.
Data indicate different roles for PDIP38 in safeguarding a proper cell division at various stages of the cell cycle, including DNA synthesis and repair, organization of the mitotic spindle and chromosome segregation.
Title: PDIP38 is a novel mitotic spindle-associated protein that affects spindle organization and chromosome segregation.
PDIP38 can shuttle between the cytoplasmic and the nuclear compartments and that its subcellular localization is regulated by CEACAM1
Title: The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38.

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General gene information

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Markers

RH134114 (e-PCR)
- UniSTS:217396

RH141066 (e-PCR)
- UniSTS:223066

RH136114 (e-PCR)
- UniSTS:210109

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in error-free translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in error-free translesion synthesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial nucleoid	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polymerase delta-interacting protein 2

Names: DNA-directed polymerase delta interacting protein 2; polymerase (DNA) delta interacting protein 2; polymerase (DNA-directed), delta interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401983.1 → NP_001388912.1 polymerase delta-interacting protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6A984, C8YL70, E9PT51

Related

ENSRNOP00000013100.7, ENSRNOT00000013100.9

Conserved Domains (2) summary

cl01119
Location:234 → 355

DUF525; ApaG domain

cl01548
Location:74 → 200

YccV-like; Hemimethylated DNA-binding protein YccV like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

63905287..63915655

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001105816.1: Suppressed sequence

Description

NM_001105816.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.