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    Hacd2 3-hydroxyacyl-CoA dehydratase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 102551408, updated on 4-Jan-2025

    Summary

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    Symbol
    Hacd2provided by RGD
    Full Name
    3-hydroxyacyl-CoA dehydratase 2provided by RGD
    Primary source
    RGD:1306337
    See related
    EnsemblRapid:ENSRNOG00000038761 AllianceGenome:RGD:1306337
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ptplb
    Summary
    Predicted to enable enzyme binding activity and very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity. Predicted to be involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human HACD2 (3-hydroxyacyl-CoA dehydratase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Liver (RPKM 45.3), Heart (RPKM 34.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hacd2 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (79175470..79268975, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (65667671..65762903, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (68985497..68990023, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551038 Neighboring gene adenylate cyclase 5 Neighboring gene uncharacterized LOC134481009 Neighboring gene uncharacterized LOC134481011 Neighboring gene myosin light chain kinase Neighboring gene uncharacterized LOC120095664

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The yeast split-ubiquitin membrane protein two-hybrid screen identifies BAP31 as a regulator of the turnover of endoplasmic reticulum-associated protein tyrosine phosphatase-like B. Wang B, et al. Mol Cell Biol, 2004 Apr. PMID 15024066, Free PMC Article
    2. Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis. Ikeda M, et al. FEBS Lett, 2008 Jul 9. PMID 18554506
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxyacyl-CoA dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2
    Names
    protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b
    protein-tyrosine phosphatase-like member B
    very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2-like
    very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2-like
    NP_001389032.1
    XP_006248501.2
    XP_038944843.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402103.1 → NP_001389032.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      Related
      ENSRNOP00000104716.1, ENSRNOT00000126686.1

    RNA

    1. NR_175003.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      Related
      ENSRNOT00000003013.10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      79175470..79268975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248439.5 → XP_006248501.2  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform X1

      Conserved Domains (1) summary
      pfam04387
      Location:85 → 167
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    2. XM_039088915.2 → XP_038944843.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform X2

      Conserved Domains (1) summary
      cl02156
      Location:37 → 141
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA
    Nucleotide Protein Strain
    Heading Accession and Version

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