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    NPY4R neuropeptide Y receptor Y4 [ Homo sapiens (human) ]

    Gene ID: 5540, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NPY4Rprovided by HGNC
    Official Full Name
    neuropeptide Y receptor Y4provided by HGNC
    Primary source
    HGNC:HGNC:9329
    See related
    Ensembl:ENSG00000204174 MIM:601790; AllianceGenome:HGNC:9329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Y4; PP1; PPYR1; NPY4-R
    Summary
    Enables pancreatic polypeptide receptor activity and peptide hormone binding activity. Involved in G protein-coupled receptor signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon (RPKM 2.9), skin (RPKM 1.7) and 7 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NPY4R in Genome Data Viewer
    Location:
    10q11.22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (46461099..46470668, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (47347139..47357909, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (47083457..47088320)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47752508-47753049 Neighboring gene annexin A8 like 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47152525-47153140 Neighboring gene long intergenic non-protein coding RNA 842 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 33 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47124851-47125351 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47124350-47124850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47107598-47108554 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47101901-47102401 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:47089605-47090205 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:47033702-47034570 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47034571-47035439 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47047925-47048424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47057528-47058124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47021543-47022511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47013295-47013796 Neighboring gene uncharacterized LOC124902419 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47008064-47008694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:46992923-46993628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:46991512-46992217 Neighboring gene G protein regulated inducer of neurite outgrowth 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:46975535-46976296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:46974774-46975534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:46974012-46974773 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:46969747-46970624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:46968867-46969746 Neighboring gene Sharpr-MPRA regulatory regions 2784 and 8617 duplicate 1 Neighboring gene SYT15 antisense RNA 1 Neighboring gene synaptotagmin 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference. Shebanits K, et al. PLoS One, 2018. PMID 29621259, Free PMC Article
    2. NPY regulates catecholamine secretion from human adrenal chromaffin cells. Cavadas C, et al. J Clin Endocrinol Metab, 2001 Dec. PMID 11739470
    3. Structure and receptor binding of PYY analogs. Keire DA, et al. Peptides, 2002 Feb. PMID 11825645
    4. Clinical potentials of neuropeptide Y family of hormones. Balasubramaniam A. Am J Surg, 2002 Apr. PMID 11975932
    5. Protein phosphatase-1 is targeted to DNA polymerase delta via an interaction with the p68 subunit. Gao Y, et al. Biochemistry, 2008 Oct 28. PMID 18826257

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Theoretical study of the interactions between peptide tyrosine tyrosine [PYY (1-36)], a newly identified modulator in type 2 diabetes pathophysiology, with receptors NPY1R and NPY4R.
      Title: Theoretical study of the interactions between peptide tyrosine tyrosine [PYY (1-36)], a newly identified modulator in type 2 diabetes pathophysiology, with receptors NPY1R and NPY4R.
    2. Our results suggest that NPY4R genetic variation influences body weight in women, but the exact role of this receptor appears to be more complex than previously proposed.
      Title: Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference.
    3. the internalization motif for the human neuropeptide Y4 receptor, which regulates arrestin-3 recruitment and receptor endocytosis, was identified.
      Title: C-terminal motif of human neuropeptide Y(4) receptor determines internalization and arrestin recruitment.
    4. A copy number variation (CNV) analysis demonstrated a significantly higher frequency of NPY4R containing 10q11.22 CNV loss in the patient population, while CNV gain in this region was more prevalent in the control population. Mutation analysis resulted in the identification of 15 rare non-synonymous heterozygous variants. Two variants in the patient population demonstrated receptor dysfunction and a pathogenic effect.
      Title: CNV analysis and mutation screening indicate an important role for the NPY4R gene in human obesity.
    5. Data suggest that repression of JNK-c-Jun signaling through pancreatic polypeptide receptor 1 (PP1) is one of the key anti-tumor mechanisms of neuronal membrane cytoskeletal protein 4.1 (4.1N).
      Title: Protein 4.1N acts as a potential tumor suppressor linking PP1 to JNK-c-Jun pathway regulation in NSCLC.
    6. These data demonstrate glucose-regulated secretion of PP and its effects on glucagon release through PPYR1 receptors expressed by alpha-cells.
      Title: Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells.
    7. Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket.
      Title: Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket.
    8. structure determination of transmembrane segments of Y4 and the yeast Ste2p G-protein-coupled receptors
      Title: Comparison of fragments comprising the first two helices of the human Y4 and the yeast Ste2p G-protein-coupled receptors.
    9. Results report on the functional reconstitution of the hY(2)R and the hY(4)R in Sf9 insect cells using the baculovirus system.
      Title: Functional reconstitution of human neuropeptide Y (NPY) Y(2) and Y(4) receptors in Sf9 insect cells.
    10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116897

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pancreatic polypeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pancreatic polypeptide receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide hormone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    neuropeptide Y receptor type 4
    Names
    pancreatic polypeptide receptor 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278794.2 → NP_001265723.1  neuropeptide Y receptor type 4

      See identical proteins and their annotated locations for NP_001265723.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC244230
      Consensus CDS
      CCDS73100.1
      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
      UniProtKB/TrEMBL
      Q4KKW2
      Related
      ENSP00000480883.1, ENST00000612632.3
      Conserved Domains (1) summary
      pfam00001
      Location:58 → 322
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. NM_005972.6 → NP_005963.4  neuropeptide Y receptor type 4

      See identical proteins and their annotated locations for NP_005963.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC244230
      Consensus CDS
      CCDS73100.1
      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
      UniProtKB/TrEMBL
      Q4KKW2
      Related
      ENSP00000363431.1, ENST00000374312.5
      Conserved Domains (1) summary
      pfam00001
      Location:58 → 322
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      46461099..46470668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539937.4 → XP_011538239.1  neuropeptide Y receptor type 4 isoform X1

      See identical proteins and their annotated locations for XP_011538239.1

      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
      UniProtKB/TrEMBL
      Q4KKW2
      Conserved Domains (1) summary
      pfam00001
      Location:58 → 322
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. XM_017016387.3 → XP_016871876.1  neuropeptide Y receptor type 4 isoform X1

      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
      UniProtKB/TrEMBL
      Q4KKW2
      Conserved Domains (1) summary
      pfam00001
      Location:58 → 322
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. XM_011539936.4 → XP_011538238.1  neuropeptide Y receptor type 4 isoform X1

      See identical proteins and their annotated locations for XP_011538238.1

      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
      UniProtKB/TrEMBL
      Q4KKW2
      Conserved Domains (1) summary
      pfam00001
      Location:58 → 322
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    4. XM_017016386.3 → XP_016871875.1  neuropeptide Y receptor type 4 isoform X1

      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
      UniProtKB/TrEMBL
      Q4KKW2
      Conserved Domains (1) summary
      pfam00001
      Location:58 → 322
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RNA

    1. XR_007061972.1 RNA Sequence

    2. XR_001747124.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      47347139..47357909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366238.1 → XP_054222213.1  neuropeptide Y receptor type 4 isoform X1

      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
      UniProtKB/TrEMBL
      Q4KKW2

    2. XM_054366237.1 → XP_054222212.1  neuropeptide Y receptor type 4 isoform X1

      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
      UniProtKB/TrEMBL
      Q4KKW2

    3. XM_054366236.1 → XP_054222211.1  neuropeptide Y receptor type 4 isoform X1

      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
      UniProtKB/TrEMBL
      Q4KKW2

    RNA

    1. XR_007080979.1 RNA Sequence

    2. XR_007080978.1 RNA Sequence

    3. XR_007080980.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50391.2 GenPept UniProtKB/Swiss-Prot:P50391

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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