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    ART1 ADP-ribosyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 417, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ART1provided by HGNC
    Official Full Name
    ADP-ribosyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:723
    See related
    Ensembl:ENSG00000129744 MIM:601625; AllianceGenome:HGNC:723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RT6; ART2; ARTC1; CD296
    Summary
    ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

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    See ART1 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (3645128..3664416)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (3690584..3729789)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (3666358..3685646)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3662929-3663642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3081 Neighboring gene transient receptor potential cation channel subfamily C member 2 (pseudogene) Neighboring gene ADP-ribosyltransferase 5 Neighboring gene cholinergic receptor nicotinic alpha 10 subunit Neighboring gene nucleoporin 98 and 96 precursor Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases. Okazaki IJ, et al. Biochemistry, 1994 Nov 1. PMID 7947688
    2. Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. Wennerberg E, et al. Sci Transl Med, 2022 Mar 16. PMID 35294260, Free PMC Article
    3. Chemotaxin-dependent translocation of immunoreactive ADP-ribosyltransferase-1 to the surface of human neutrophil polymorphs. Kefalas P, et al. Eur J Biochem, 1999 Feb. PMID 10092875
    4. Expression of ADP-ribosyltransferase 1 Is Associated with Poor Prognosis of Glioma Patients. Li Z, et al. Tohoku J Exp Med, 2016 Aug. PMID 27466078
    5. Regulation of the RhoA/ROCK/AKT/β-catenin pathway by arginine-specific ADP-ribosytransferases 1 promotes migration and epithelial-mesenchymal transition in colon carcinoma. Song GL, et al. Int J Oncol, 2016 Aug. PMID 27277835

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ART1 knockdown decreases the IL-6-induced proliferation of colorectal cancer cells.
      Title: ART1 knockdown decreases the IL-6-induced proliferation of colorectal cancer cells.
    2. ARTC1-mediated VAPB ADP-ribosylation regulates calcium homeostasis.
      Title: ARTC1-mediated VAPB ADP-ribosylation regulates calcium homeostasis.
    3. Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer.
      Title: Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer.
    4. Our data suggest that ART1 could regulate EMT by regulating the RhoA/ROCK1/AKT/beta-catenin pathway and its downstream factors (snail1, vimentin, N-cadherin and E-cadherin) and that it therefore plays an important role in the progression of colon carcinoma.
      Title: Regulation of the RhoA/ROCK/AKT/β-catenin pathway by arginine-specific ADP-ribosytransferases 1 promotes migration and epithelial-mesenchymal transition in colon carcinoma.
    5. up-regulation of ART1 expression is associated with the aggressiveness of glioma.
      Title: Expression of ADP-ribosyltransferase 1 Is Associated with Poor Prognosis of Glioma Patients.
    6. Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway
      Title: Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway.
    7. The altered function and expression of P2X7 and ART1 in the human CD39+ Treg or CD39- Treg cells could participate in the resistance against cell death induced by ATP or NAD.
      Title: Evaluation of the expression and function of the P2X7 receptor and ART1 in human regulatory T-cell subsets.
    8. This study provides evidence that ARTC1 is activated during the endoplasmic-reticulum stress response, which results in acute ADP-ribosylation of GRP78/BiP paralleling translational inhibition.
      Title: ARTC1-mediated ADP-ribosylation of GRP78/BiP: a new player in endoplasmic-reticulum stress responses.
    9. ADPRT Ala762Val polymorphism may play a role in the etiology of squamous cell carcinoma of the head and neck or in linkage disequilibrium with other untyped protective alleles.
      Title: Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck.
    10. ADP-ribosylation of HNP-1 appears to be primarily an activity of ART1 and occurs in inflammatory conditions and disease
      Title: ADP-ribosyltransferase-specific modification of human neutrophil peptide-1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC133217

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein-arginine ADP-ribosyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
    Names
    ADP-ribosyltransferase 2
    ADP-ribosyltransferase C2 and C3 toxin-like 1
    mono(ADP-ribosyl)transferase 1
    NP_004305.2
    XP_011518416.1
    XP_016873252.1
    XP_054224799.1
    XP_054224800.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004314.3 → NP_004305.2  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor

      See identical proteins and their annotated locations for NP_004305.2

      Status: REVIEWED

      Source sequence(s)
      AC060812, BC069102, S74683
      Consensus CDS
      CCDS7744.1
      UniProtKB/Swiss-Prot
      P52961, Q6NTD2, Q96KT9
      Related
      ENSP00000250693.1, ENST00000250693.2
      Conserved Domains (1) summary
      pfam01129
      Location:39 → 274
      ART; NAD:arginine ADP-ribosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      3645128..3664416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017763.3 → XP_016873252.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      P52961, Q6NTD2, Q96KT9
      Conserved Domains (1) summary
      pfam01129
      Location:39 → 274
      ART; NAD:arginine ADP-ribosyltransferase

    2. XM_011520114.4 → XP_011518416.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_011518416.1

      UniProtKB/Swiss-Prot
      P52961, Q6NTD2, Q96KT9
      Conserved Domains (1) summary
      pfam01129
      Location:39 → 274
      ART; NAD:arginine ADP-ribosyltransferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      3690584..3729789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368825.1 → XP_054224800.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

    2. XM_054368824.1 → XP_054224799.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52961.2 GenPept UniProtKB/Swiss-Prot:P52961

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