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    CDC42BPG CDC42 binding protein kinase gamma [ Homo sapiens (human) ]

    Gene ID: 55561, updated on 9-Dec-2024

    Summary

    Official Symbol
    CDC42BPGprovided by HGNC
    Official Full Name
    CDC42 binding protein kinase gammaprovided by HGNC
    Primary source
    HGNC:HGNC:29829
    See related
    Ensembl:ENSG00000171219 MIM:613991; AllianceGenome:HGNC:29829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DMPK2; MRCKG; HSMDPKIN; KAPPA-200; MRCKgamma
    Summary
    Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in cell leading edge; centriolar satellite; and cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in skin (RPKM 11.8), stomach (RPKM 5.1) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CDC42BPG in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64823052..64844653, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64816347..64837971, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64590524..64612125, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64557481-64557982 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene Sharpr-MPRA regulatory region 11124 Neighboring gene MPRA-validated peak1298 silencer Neighboring gene Sharpr-MPRA regulatory region 2965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3491 Neighboring gene menin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64594480-64594980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64609163-64609975 Neighboring gene Sharpr-MPRA regulatory region 8286 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64610788-64611600 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3493 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3494 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4921 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64620804-64621802 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:64622049-64623248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4925 Neighboring gene EH domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64630869-64631680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4928 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:64641208-64641398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64644230-64645006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4932 Neighboring gene microRNA 10392 Neighboring gene ribosomal protein S16 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase MRCK gamma
    Names
    CDC42 binding protein kinase gamma (DMPK-like)
    DMPK-like gamma
    MRCK gamma
    myotonic dystrophy kinase-related CDC42-binding kinase gamma
    myotonic dystrophy protein kinase like protein
    myotonic dystrophy protein kinase-like alpha
    myotonic dystrophy protein kinase-like gamma
    NP_059995.2
    XP_011543457.1
    XP_011543458.1
    XP_011543459.1
    XP_011543460.1
    XP_011543461.1
    XP_011543462.1
    XP_011543463.1
    XP_016873485.1
    XP_016873486.1
    XP_016873487.1
    XP_047283204.1
    XP_047283205.1
    XP_047283206.1
    XP_047283207.1
    XP_054225299.1
    XP_054225300.1
    XP_054225301.1
    XP_054225302.1
    XP_054225303.1
    XP_054225304.1
    XP_054225305.1
    XP_054225306.1
    XP_054225307.1
    XP_054225308.1
    XP_054225309.1
    XP_054225310.1
    XP_054225311.1
    XP_054225312.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017525.3NP_059995.2  serine/threonine-protein kinase MRCK gamma

      See identical proteins and their annotated locations for NP_059995.2

      Status: VALIDATED

      Source sequence(s)
      AP001187, AY648038, BI793270
      Consensus CDS
      CCDS31601.1
      UniProtKB/Swiss-Prot
      O00565, Q6DT37
      Related
      ENSP00000345133.5, ENST00000342711.6
      Conserved Domains (7) summary
      pfam08826
      Location:744801
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:71337
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01243
      Location:9381070
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:69399
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:879921
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:10971360
      CNH; CNH domain
      pfam13868
      Location:410802
      TPH; Trichohyalin-plectin-homology domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      64823052..64844653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427250.1XP_047283206.1  serine/threonine-protein kinase MRCK gamma isoform X7

    2. XM_047427248.1XP_047283204.1  serine/threonine-protein kinase MRCK gamma isoform X4

    3. XM_011545156.4XP_011543458.1  serine/threonine-protein kinase MRCK gamma isoform X3

      Conserved Domains (7) summary
      pfam08826
      Location:737794
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:71337
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01243
      Location:9491081
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:69399
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:890932
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:11081371
      CNH; CNH domain
      pfam15558
      Location:422794
      DUF4659; Domain of unknown function (DUF4659)
    4. XM_017017996.3XP_016873485.1  serine/threonine-protein kinase MRCK gamma isoform X2

    5. XM_047427249.1XP_047283205.1  serine/threonine-protein kinase MRCK gamma isoform X6

    6. XM_011545158.4XP_011543460.1  serine/threonine-protein kinase MRCK gamma isoform X8

      Conserved Domains (7) summary
      pfam08826
      Location:744801
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:71337
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01243
      Location:9561088
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:69399
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:897939
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13868
      Location:410802
      TPH; Trichohyalin-plectin-homology domain
      cl02434
      Location:11151340
      CNH; CNH domain
    7. XM_011545157.4XP_011543459.1  serine/threonine-protein kinase MRCK gamma isoform X5

      Conserved Domains (7) summary
      pfam08826
      Location:744801
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:71337
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01243
      Location:9561088
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:69399
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:897939
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13868
      Location:410802
      TPH; Trichohyalin-plectin-homology domain
      cl02434
      Location:11151340
      CNH; CNH domain
    8. XM_011545155.4XP_011543457.1  serine/threonine-protein kinase MRCK gamma isoform X1

      See identical proteins and their annotated locations for XP_011543457.1

      Conserved Domains (7) summary
      pfam08826
      Location:744801
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:71337
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01243
      Location:9561088
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:69399
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:897939
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:11151378
      CNH; CNH domain
      pfam13868
      Location:410802
      TPH; Trichohyalin-plectin-homology domain
    9. XM_011545160.4XP_011543462.1  serine/threonine-protein kinase MRCK gamma isoform X10

      Conserved Domains (8) summary
      pfam08826
      Location:646703
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:1239
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01243
      Location:858990
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:1301
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:799841
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00169
      Location:870986
      PH; PH domain
      pfam00780
      Location:10171280
      CNH; CNH domain
      pfam13868
      Location:312704
      TPH; Trichohyalin-plectin-homology domain
    10. XM_011545159.4XP_011543461.1  serine/threonine-protein kinase MRCK gamma isoform X9

      Conserved Domains (7) summary
      pfam08826
      Location:744801
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:71337
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01243
      Location:9561088
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:69399
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:897939
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:11151378
      CNH; CNH domain
      pfam13868
      Location:410802
      TPH; Trichohyalin-plectin-homology domain
    11. XM_017017998.3XP_016873487.1  serine/threonine-protein kinase MRCK gamma isoform X14

    12. XM_047427251.1XP_047283207.1  serine/threonine-protein kinase MRCK gamma isoform X13

    13. XM_017017997.3XP_016873486.1  serine/threonine-protein kinase MRCK gamma isoform X11

    14. XM_011545161.4XP_011543463.1  serine/threonine-protein kinase MRCK gamma isoform X12

      Conserved Domains (5) summary
      pfam08826
      Location:744801
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:71337
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01243
      Location:9561088
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:69399
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:897939
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RNA

    1. XR_949988.4 RNA Sequence

    2. XR_949989.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      64816347..64837971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369330.1XP_054225305.1  serine/threonine-protein kinase MRCK gamma isoform X7

    2. XM_054369327.1XP_054225302.1  serine/threonine-protein kinase MRCK gamma isoform X4

    3. XM_054369326.1XP_054225301.1  serine/threonine-protein kinase MRCK gamma isoform X3

    4. XM_054369325.1XP_054225300.1  serine/threonine-protein kinase MRCK gamma isoform X2

    5. XM_054369329.1XP_054225304.1  serine/threonine-protein kinase MRCK gamma isoform X6

    6. XM_054369331.1XP_054225306.1  serine/threonine-protein kinase MRCK gamma isoform X8

    7. XM_054369328.1XP_054225303.1  serine/threonine-protein kinase MRCK gamma isoform X5

    8. XM_054369324.1XP_054225299.1  serine/threonine-protein kinase MRCK gamma isoform X1

    9. XM_054369333.1XP_054225308.1  serine/threonine-protein kinase MRCK gamma isoform X10

    10. XM_054369332.1XP_054225307.1  serine/threonine-protein kinase MRCK gamma isoform X9

    11. XM_054369337.1XP_054225312.1  serine/threonine-protein kinase MRCK gamma isoform X14

    12. XM_054369336.1XP_054225311.1  serine/threonine-protein kinase MRCK gamma isoform X13

    13. XM_054369334.1XP_054225309.1  serine/threonine-protein kinase MRCK gamma isoform X11

    14. XM_054369335.1XP_054225310.1  serine/threonine-protein kinase MRCK gamma isoform X12

    RNA

    1. XR_008488418.1 RNA Sequence

    2. XR_008488419.1 RNA Sequence