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    WNK1 WNK lysine deficient protein kinase 1 [ Homo sapiens (human) ]

    Gene ID: 65125, updated on 27-Nov-2024

    Summary

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    Official Symbol
    WNK1provided by HGNC
    Official Full Name
    WNK lysine deficient protein kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:14540
    See related
    Ensembl:ENSG00000060237 MIM:605232; AllianceGenome:HGNC:14540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KDP; PSK; p65; HSN2; HSAN2; PRKWNK1; PPP1R167
    Summary
    This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in kidney (RPKM 30.2), fat (RPKM 24.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See WNK1 in Genome Data Viewer
    Location:
    12p13.33
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (752579..911452)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (748443..907208)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (861745..1020618)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4103 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5779 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4105 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:754531-755730 Neighboring gene Sharpr-MPRA regulatory region 6322 Neighboring gene ninjurin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:775809-776308 Neighboring gene NINJ2 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:780043-780251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5783 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5786 Neighboring gene uncharacterized LOC101929432 Neighboring gene long intergenic non-protein coding RNA 2455 Neighboring gene CRISPRi-validated cis-regulatory element chr12.51 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5788 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5790 Neighboring gene H3K27ac hESC enhancers GRCh37_chr12:861758-862476 and GRCh37_chr12:862477-863195 Neighboring gene RNA, U4atac small nuclear 16, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5791 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:917646-918146 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:918147-918647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5792 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:1023012-1024211 Neighboring gene uncharacterized LOC124902855 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:1058032-1058690 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:1058691-1059349 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1067429-1067930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1067931-1068430 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:1083331-1083878 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:1092618-1092819 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:1099220-1099782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:1100344-1100905 Neighboring gene Sharpr-MPRA regulatory region 6010 Neighboring gene RAD52 homolog, DNA repair protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1115216-1115716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1115717-1116217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1181067-1181567 Neighboring gene ELKS/RAB6-interacting/CAST family member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5795 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:1224566-1225765 Neighboring gene uncharacterized LOC124902857

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Carriers of recessive WNK1/HSN2 mutations for hereditary sensory and autonomic neuropathy type 2 (HSAN2) are more sensitive to thermal stimuli. Loggia ML, et al. J Neurosci, 2009 Feb 18. PMID 19228968, Free PMC Article
    2. Aberrant expression of WNK lysine deficient protein kinase 1 is associated with poor prognosis of colon adenocarcinoma. Jiang H, et al. Ir J Med Sci, 2023 Feb. PMID 35138567
    3. Novel mutations in the HSN2 gene causing hereditary sensory and autonomic neuropathy type II. Coen K, et al. Neurology, 2006 Mar 14. PMID 16534117
    4. Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress. Zagórska A, et al. J Cell Biol, 2007 Jan 1. PMID 17190791, Free PMC Article
    5. Common variation in with no-lysine kinase 1 (WNK1) and blood pressure responses to dietary sodium or potassium interventions- family-based association study. Liu F, et al. Circ J, 2013. PMID 23059770

    See all (216) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma.
      Title: WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma.
    2. The CREB1/WNK1 axis promotes the tumorigenesis of ovarian cancer via regulating HIF-1.
      Title: The CREB1/WNK1 axis promotes the tumorigenesis of ovarian cancer via regulating HIF-1.
    3. Circular RNA circWNK1 inhibits the progression of gastric cancer via regulating the miR-21-3p/SMAD7 axis.
      Title: Circular RNA circWNK1 inhibits the progression of gastric cancer via regulating the miR-21-3p/SMAD7 axis.
    4. A Spanish Family with Gordon Syndrome Due to a Variant in the Acidic Motif of WNK1.
      Title: A Spanish Family with Gordon Syndrome Due to a Variant in the Acidic Motif of WNK1.
    5. WNK1 mediates amphiregulin-induced MMP9 expression and cell invasion in human extravillous trophoblast cells.
      Title: WNK1 mediates amphiregulin-induced MMP9 expression and cell invasion in human extravillous trophoblast cells.
    6. WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly.
      Title: WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly.
    7. Aberrant expression of WNK lysine deficient protein kinase 1 is associated with poor prognosis of colon adenocarcinoma.
      Title: Aberrant expression of WNK lysine deficient protein kinase 1 is associated with poor prognosis of colon adenocarcinoma.
    8. Loss of WNK1 Suppressed the Malignant Behaviors of Hepatocellular Carcinoma Cells by Promoting Autophagy and Activating AMPK Pathway.
      Title: Loss of WNK1 Suppressed the Malignant Behaviors of Hepatocellular Carcinoma Cells by Promoting Autophagy and Activating AMPK Pathway.
    9. WNK1/HSN2 mediates neurite outgrowth and differentiation via a OSR1/GSK3beta-LHX8 pathway.
      Title: WNK1/HSN2 mediates neurite outgrowth and differentiation via a OSR1/GSK3β-LHX8 pathway.
    10. WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.
      Title: WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.
    Submit: New GeneRIF Correction See all GeneRIFs (106)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of WNK lysine deficient protein kinase 1 (WNK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed
    Knockdown of WNK lysine deficient protein kinase 1 (WNK1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0344, MGC163339, MGC163341

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular condensate scaffold activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cell volume homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular hyperosmotic response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to chemokine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemokine (C-C motif) ligand 21 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular chloride ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in lymphocyte migration into lymph node ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in membraneless organelle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic cation homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monoatomic ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell-cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of heterotypic cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of leukocyte cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of pancreatic juice secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of peptidyl-threonine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of T cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cytokinesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of termination of RNA polymerase II transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of regulation of monoatomic cation transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in intracellular membraneless organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase WNK1
    Names
    erythrocyte 65 kDa protein
    prostate-derived sterile 20-like kinase
    protein kinase with no lysine 1
    protein phosphatase 1, regulatory subunit 167
    serine/threonine-protein kinase WNK1 1
    serine/threonine-protein kinase WNK1 2
    NP_001171914.1
    NP_055638.2
    NP_061852.3
    NP_998820.3
    XP_006719066.1
    XP_011519299.1
    XP_011519300.1
    XP_011519301.1
    XP_011519302.1
    XP_011519303.1
    XP_011519304.1
    XP_011519305.1
    XP_011519308.1
    XP_011519309.1
    XP_011519310.1
    XP_011519311.1
    XP_016875323.1
    XP_016875324.1
    XP_016875325.1
    XP_016875326.1
    XP_016875327.1
    XP_047285330.1
    XP_047285331.1
    XP_047285332.1
    XP_047285333.1
    XP_047285334.1
    XP_047285335.1
    XP_047285336.1
    XP_047285337.1
    XP_047285338.1
    XP_047285339.1
    XP_047285340.1
    XP_047285341.1
    XP_047285342.1
    XP_047285343.1
    XP_047285344.1
    XP_047285345.1
    XP_047285346.1
    XP_047285347.1
    XP_047285348.1
    XP_047285349.1
    XP_047285350.1
    XP_047285351.1
    XP_047285352.1
    XP_047285353.1
    XP_047285354.1
    XP_047285355.1
    XP_047285356.1
    XP_047285357.1
    XP_047285358.1
    XP_047285359.1
    XP_054228909.1
    XP_054228910.1
    XP_054228911.1
    XP_054228912.1
    XP_054228913.1
    XP_054228914.1
    XP_054228915.1
    XP_054228916.1
    XP_054228917.1
    XP_054228918.1
    XP_054228919.1
    XP_054228920.1
    XP_054228921.1
    XP_054228922.1
    XP_054228923.1
    XP_054228924.1
    XP_054228925.1
    XP_054228926.1
    XP_054228927.1
    XP_054228928.1
    XP_054228929.1
    XP_054228930.1
    XP_054228931.1
    XP_054228932.1
    XP_054228933.1
    XP_054228934.1
    XP_054228935.1
    XP_054228936.1
    XP_054228937.1
    XP_054228938.1
    XP_054228939.1
    XP_054228940.1
    XP_054228941.1
    XP_054228942.1
    XP_054228943.1
    XP_054228944.1
    XP_054228945.1
    XP_054228946.1
    XP_054228947.1
    XP_054228948.1
    XP_054228949.1
    XP_054228950.1
    XP_054228951.1
    XP_054228952.1
    XP_054228953.1
    XP_054228954.1
    XP_054228955.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007984.3 RefSeqGene

      Range
      4521..163394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_247

    mRNA and Protein(s)

    1. NM_001184985.2 → NP_001171914.1  serine/threonine-protein kinase WNK1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame compared to variant 1. This variant represents the exon combination of the dorsal root ganglia and sciatic nerve variant described in Figure 2F of PubMed ID 18521183. This variant encodes isoform 4, which is longer than isoform 1.
      Source sequence(s)
      AC004765, AC004803
      UniProtKB/Swiss-Prot
      Q9H4A3
      Related
      ENSP00000444465.1, ENST00000537687.5
      Conserved Domains (3) summary
      smart00220
      Location:226 → 479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    2. NM_014823.3 → NP_055638.2  serine/threonine-protein kinase WNK1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses two alternative splice sites and lacks two exons in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AB002342, AC004765, AC004803, AI074334, AJ296290, BC141881, BX644268, CD629562, DA720959
      Consensus CDS
      CCDS53731.1
      UniProtKB/TrEMBL
      F5GWT4
      Related
      ENSP00000441972.1, ENST00000535572.5
      Conserved Domains (3) summary
      smart00220
      Location:226 → 479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    3. NM_018979.4 → NP_061852.3  serine/threonine-protein kinase WNK1 isoform 1

      See identical proteins and their annotated locations for NP_061852.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the most common isoform (1), as indicated in PubMed ID 18521183.
      Source sequence(s)
      AB002342, AC004765, AC004803, AI074334, AJ296290, BC141881, BX644268, CD629562, DA720959
      Consensus CDS
      CCDS8506.1
      UniProtKB/Swiss-Prot
      A1L4B0, C5HTZ5, C5HTZ6, C5HTZ7, H6WZW3, O15052, P54963, Q4VBX9, Q6IFS5, Q86WL5, Q8N673, Q96CZ6, Q9H4A3, Q9P1S9
      Related
      ENSP00000313059.6, ENST00000315939.11
      Conserved Domains (3) summary
      smart00220
      Location:226 → 479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    4. NM_213655.5 → NP_998820.3  serine/threonine-protein kinase WNK1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame compared to variant 1. This variant represents the exon combination of the brain and spinal cord variant described in Figure 2F of PubMed ID 18521183. This variant encodes isoform 3, which is longer than isoform 1.
      Source sequence(s)
      AC004765, AC004803
      Consensus CDS
      CCDS73419.1
      UniProtKB/Swiss-Prot
      Q9H4A3
      Related
      ENSP00000341292.5, ENST00000340908.9
      Conserved Domains (3) summary
      smart00220
      Location:226 → 479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      752579..911452
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520997.4 → XP_011519299.1  serine/threonine-protein kinase WNK1 isoform X1

      Related
      ENSP00000433548.3, ENST00000530271.6
      Conserved Domains (3) summary
      smart00220
      Location:226 → 479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    2. XM_011521000.3 → XP_011519302.1  serine/threonine-protein kinase WNK1 isoform X4

      Conserved Domains (3) summary
      smart00220
      Location:226 → 479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    3. XM_011520999.3 → XP_011519301.1  serine/threonine-protein kinase WNK1 isoform X3

      Conserved Domains (3) summary
      smart00220
      Location:226 → 479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    4. XM_047429374.1 → XP_047285330.1  serine/threonine-protein kinase WNK1 isoform X5

    5. XM_011521001.3 → XP_011519303.1  serine/threonine-protein kinase WNK1 isoform X6

      Conserved Domains (3) summary
      smart00220
      Location:226 → 479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    6. XM_047429375.1 → XP_047285331.1  serine/threonine-protein kinase WNK1 isoform X7

    7. XM_047429376.1 → XP_047285332.1  serine/threonine-protein kinase WNK1 isoform X9

    8. XM_011521003.3 → XP_011519305.1  serine/threonine-protein kinase WNK1 isoform X10

      Conserved Domains (3) summary
      smart00220
      Location:226 → 479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    9. XM_011520998.3 → XP_011519300.1  serine/threonine-protein kinase WNK1 isoform X2

      Conserved Domains (3) summary
      smart00220
      Location:226 → 479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    10. XM_011521002.3 → XP_011519304.1  serine/threonine-protein kinase WNK1 isoform X8

      Conserved Domains (3) summary
      smart00220
      Location:226 → 479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    11. XM_047429377.1 → XP_047285333.1  serine/threonine-protein kinase WNK1 isoform X12

    12. XM_047429380.1 → XP_047285336.1  serine/threonine-protein kinase WNK1 isoform X17

    13. XM_047429383.1 → XP_047285339.1  serine/threonine-protein kinase WNK1 isoform X20

    14. XM_047429388.1 → XP_047285344.1  serine/threonine-protein kinase WNK1 isoform X25

    15. XM_047429393.1 → XP_047285349.1  serine/threonine-protein kinase WNK1 isoform X33

    16. XM_047429389.1 → XP_047285345.1  serine/threonine-protein kinase WNK1 isoform X27

    17. XM_017019837.2 → XP_016875326.1  serine/threonine-protein kinase WNK1 isoform X34

      Conserved Domains (3) summary
      smart00220
      Location:226 → 479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    18. XM_047429400.1 → XP_047285356.1  serine/threonine-protein kinase WNK1 isoform X44

    19. XM_047429395.1 → XP_047285351.1  serine/threonine-protein kinase WNK1 isoform X37

    20. XM_006719003.3 → XP_006719066.1  serine/threonine-protein kinase WNK1 isoform X11

      Conserved Domains (2) summary
      PHA03247
      Location:1572 → 1866
      PHA03247; large tegument protein UL36; Provisional
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

    21. XM_047429378.1 → XP_047285334.1  serine/threonine-protein kinase WNK1 isoform X13

    22. XM_047429382.1 → XP_047285338.1  serine/threonine-protein kinase WNK1 isoform X19

    23. XM_047429384.1 → XP_047285340.1  serine/threonine-protein kinase WNK1 isoform X21

    24. XM_017019834.2 → XP_016875323.1  serine/threonine-protein kinase WNK1 isoform X26

    25. XM_047429390.1 → XP_047285346.1  serine/threonine-protein kinase WNK1 isoform X28

    26. XM_017019838.2 → XP_016875327.1  serine/threonine-protein kinase WNK1 isoform X36

    27. XM_047429401.1 → XP_047285357.1  serine/threonine-protein kinase WNK1 isoform X45

    28. XM_047429402.1 → XP_047285358.1  serine/threonine-protein kinase WNK1 isoform X46

    29. XM_011521006.3 → XP_011519308.1  serine/threonine-protein kinase WNK1 isoform X14

      Conserved Domains (3) summary
      smart00220
      Location:226 → 479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    30. XM_047429381.1 → XP_047285337.1  serine/threonine-protein kinase WNK1 isoform X18

    31. XM_047429379.1 → XP_047285335.1  serine/threonine-protein kinase WNK1 isoform X16

    32. XM_047429385.1 → XP_047285341.1  serine/threonine-protein kinase WNK1 isoform X22

    33. XM_017019835.2 → XP_016875324.1  serine/threonine-protein kinase WNK1 isoform X29

    34. XM_047429394.1 → XP_047285350.1  serine/threonine-protein kinase WNK1 isoform X35

    35. XM_047429391.1 → XP_047285347.1  serine/threonine-protein kinase WNK1 isoform X31

    36. XM_047429397.1 → XP_047285353.1  serine/threonine-protein kinase WNK1 isoform X39

    37. XM_011521008.3 → XP_011519310.1  serine/threonine-protein kinase WNK1 isoform X40

      Conserved Domains (3) summary
      smart00220
      Location:226 → 479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    38. XM_047429398.1 → XP_047285354.1  serine/threonine-protein kinase WNK1 isoform X42

    39. XM_011521007.3 → XP_011519309.1  serine/threonine-protein kinase WNK1 isoform X15

      Conserved Domains (3) summary
      smart00220
      Location:226 → 479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    40. XM_047429386.1 → XP_047285342.1  serine/threonine-protein kinase WNK1 isoform X23

    41. XM_047429387.1 → XP_047285343.1  serine/threonine-protein kinase WNK1 isoform X24

    42. XM_017019836.2 → XP_016875325.1  serine/threonine-protein kinase WNK1 isoform X30

    43. XM_047429396.1 → XP_047285352.1  serine/threonine-protein kinase WNK1 isoform X38

    44. XM_047429392.1 → XP_047285348.1  serine/threonine-protein kinase WNK1 isoform X32

    45. XM_011521009.3 → XP_011519311.1  serine/threonine-protein kinase WNK1 isoform X41

      Conserved Domains (3) summary
      smart00220
      Location:226 → 479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195 → 483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    46. XM_047429399.1 → XP_047285355.1  serine/threonine-protein kinase WNK1 isoform X43

    47. XM_047429403.1 → XP_047285359.1  serine/threonine-protein kinase WNK1 isoform X47

      Related
      ENSP00000502415.1, ENST00000675631.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      748443..907208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372934.1 → XP_054228909.1  serine/threonine-protein kinase WNK1 isoform X1

    2. XM_054372937.1 → XP_054228912.1  serine/threonine-protein kinase WNK1 isoform X4

    3. XM_054372936.1 → XP_054228911.1  serine/threonine-protein kinase WNK1 isoform X3

    4. XM_054372938.1 → XP_054228913.1  serine/threonine-protein kinase WNK1 isoform X5

    5. XM_054372939.1 → XP_054228914.1  serine/threonine-protein kinase WNK1 isoform X6

    6. XM_054372940.1 → XP_054228915.1  serine/threonine-protein kinase WNK1 isoform X7

    7. XM_054372942.1 → XP_054228917.1  serine/threonine-protein kinase WNK1 isoform X9

    8. XM_054372943.1 → XP_054228918.1  serine/threonine-protein kinase WNK1 isoform X10

    9. XM_054372935.1 → XP_054228910.1  serine/threonine-protein kinase WNK1 isoform X2

    10. XM_054372941.1 → XP_054228916.1  serine/threonine-protein kinase WNK1 isoform X8

    11. XM_054372945.1 → XP_054228920.1  serine/threonine-protein kinase WNK1 isoform X12

    12. XM_054372950.1 → XP_054228925.1  serine/threonine-protein kinase WNK1 isoform X17

    13. XM_054372953.1 → XP_054228928.1  serine/threonine-protein kinase WNK1 isoform X20

    14. XM_054372958.1 → XP_054228933.1  serine/threonine-protein kinase WNK1 isoform X25

    15. XM_054372966.1 → XP_054228941.1  serine/threonine-protein kinase WNK1 isoform X33

    16. XM_054372960.1 → XP_054228935.1  serine/threonine-protein kinase WNK1 isoform X27

    17. XM_054372967.1 → XP_054228942.1  serine/threonine-protein kinase WNK1 isoform X34

    18. XM_054372977.1 → XP_054228952.1  serine/threonine-protein kinase WNK1 isoform X44

    19. XM_054372970.1 → XP_054228945.1  serine/threonine-protein kinase WNK1 isoform X37

    20. XM_054372944.1 → XP_054228919.1  serine/threonine-protein kinase WNK1 isoform X11

    21. XM_054372946.1 → XP_054228921.1  serine/threonine-protein kinase WNK1 isoform X13

    22. XM_054372952.1 → XP_054228927.1  serine/threonine-protein kinase WNK1 isoform X19

    23. XM_054372954.1 → XP_054228929.1  serine/threonine-protein kinase WNK1 isoform X21

    24. XM_054372959.1 → XP_054228934.1  serine/threonine-protein kinase WNK1 isoform X26

    25. XM_054372961.1 → XP_054228936.1  serine/threonine-protein kinase WNK1 isoform X28

    26. XM_054372969.1 → XP_054228944.1  serine/threonine-protein kinase WNK1 isoform X36

    27. XM_054372978.1 → XP_054228953.1  serine/threonine-protein kinase WNK1 isoform X45

    28. XM_054372979.1 → XP_054228954.1  serine/threonine-protein kinase WNK1 isoform X46

    29. XM_054372947.1 → XP_054228922.1  serine/threonine-protein kinase WNK1 isoform X14

    30. XM_054372951.1 → XP_054228926.1  serine/threonine-protein kinase WNK1 isoform X18

    31. XM_054372949.1 → XP_054228924.1  serine/threonine-protein kinase WNK1 isoform X16

    32. XM_054372955.1 → XP_054228930.1  serine/threonine-protein kinase WNK1 isoform X22

    33. XM_054372962.1 → XP_054228937.1  serine/threonine-protein kinase WNK1 isoform X29

    34. XM_054372968.1 → XP_054228943.1  serine/threonine-protein kinase WNK1 isoform X35

    35. XM_054372964.1 → XP_054228939.1  serine/threonine-protein kinase WNK1 isoform X31

    36. XM_054372972.1 → XP_054228947.1  serine/threonine-protein kinase WNK1 isoform X39

    37. XM_054372973.1 → XP_054228948.1  serine/threonine-protein kinase WNK1 isoform X40

    38. XM_054372975.1 → XP_054228950.1  serine/threonine-protein kinase WNK1 isoform X42

    39. XM_054372948.1 → XP_054228923.1  serine/threonine-protein kinase WNK1 isoform X15

    40. XM_054372956.1 → XP_054228931.1  serine/threonine-protein kinase WNK1 isoform X23

    41. XM_054372957.1 → XP_054228932.1  serine/threonine-protein kinase WNK1 isoform X24

    42. XM_054372963.1 → XP_054228938.1  serine/threonine-protein kinase WNK1 isoform X30

    43. XM_054372971.1 → XP_054228946.1  serine/threonine-protein kinase WNK1 isoform X38

    44. XM_054372965.1 → XP_054228940.1  serine/threonine-protein kinase WNK1 isoform X32

    45. XM_054372974.1 → XP_054228949.1  serine/threonine-protein kinase WNK1 isoform X41

    46. XM_054372976.1 → XP_054228951.1  serine/threonine-protein kinase WNK1 isoform X43

    47. XM_054372980.1 → XP_054228955.1  serine/threonine-protein kinase WNK1 isoform X47

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H4A3.2 GenPept UniProtKB/Swiss-Prot:Q9H4A3

    Gene LinkOut

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