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    UNC79 unc-79 homolog, NALCN channel complex subunit [ Homo sapiens (human) ]

    Gene ID: 57578, updated on 27-Nov-2024

    Summary

    Official Symbol
    UNC79provided by HGNC
    Official Full Name
    unc-79 homolog, NALCN channel complex subunitprovided by HGNC
    Primary source
    HGNC:HGNC:19966
    See related
    Ensembl:ENSG00000133958 MIM:616884; AllianceGenome:HGNC:19966
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIAA1409
    Summary
    The NALCN channel is responsible for Na(+) leak currents. The protein encoded by this gene, along with UNC80, is an accessory subunit of the NALCN channel that contributes to the Ca(2+) sensitivity of the channel. [provided by RefSeq, Sep 2016]
    Expression
    Biased expression in brain (RPKM 2.1), testis (RPKM 1.1) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See UNC79 in Genome Data Viewer
    Location:
    14q32.12
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (93333182..93707876)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (87565061..87935165)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (93799528..94174222)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18a pseudogene 1 Neighboring gene ubiquitin protein ligase E3 component n-recognin 7 Neighboring gene ribosomal protein L36a pseudogene 4 Neighboring gene BTB domain containing 7 Neighboring gene NANOG hESC enhancer GRCh37_chr14:93810118-93810619 Neighboring gene cytochrome c oxidase subunit 8C Neighboring gene RNA, U6 small nuclear 1258, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:93956171-93956670 Neighboring gene NANOG hESC enhancer GRCh37_chr14:94025779-94026281 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:94153830-94154524 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:94154525-94155218 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:94155913-94156606 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:94155219-94155912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94173027-94173527 Neighboring gene uncharacterized LOC124903367 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94215113-94215986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94226183-94226683 Neighboring gene proline rich membrane anchor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94245793-94246294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:94254197-94254908 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:94254909-94255622

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ43337, KIAA1409

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051662.1 RefSeqGene

      Range
      102721..379658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001346218.2NP_001333147.1  protein unc-79 homolog isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL122023, AL136338, AL157858
      Consensus CDS
      CCDS91921.1
      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
      UniProtKB/TrEMBL
      A0A8Q3SHN5
      Related
      ENSP00000511644.1, ENST00000695013.1
    2. NM_001395159.1NP_001382088.1  protein unc-79 homolog isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL122023, AL136338, AL157858
      Consensus CDS
      CCDS91920.1
      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
      UniProtKB/TrEMBL
      A0A8Q3SHI5
      Related
      ENSP00000511643.1, ENST00000695012.1
      Conserved Domains (1) summary
      pfam14776
      Location:114645
      UNC-79; Cation-channel complex subunit UNC-79
    3. NM_020818.5NP_065869.3  protein unc-79 homolog isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AL122023, AL136338, AL157858
      Consensus CDS
      CCDS9911.2
      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
      Related
      ENSP00000256339.4, ENST00000256339.8
      Conserved Domains (1) summary
      pfam14776
      Location:1468
      UNC-79; Cation-channel complex subunit UNC-79

    RNA

    1. NR_144398.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' end compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
      Source sequence(s)
      AL122023

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      93333182..93707876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537027.3XP_011535329.1  protein unc-79 homolog isoform X22

      See identical proteins and their annotated locations for XP_011535329.1

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
      Conserved Domains (1) summary
      pfam14776
      Location:46578
      UNC-79; Cation-channel complex subunit UNC-79
    2. XM_011537026.3XP_011535328.1  protein unc-79 homolog isoform X22

      See identical proteins and their annotated locations for XP_011535328.1

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
      Conserved Domains (1) summary
      pfam14776
      Location:46578
      UNC-79; Cation-channel complex subunit UNC-79
    3. XM_047431624.1XP_047287580.1  protein unc-79 homolog isoform X15

    4. XM_024449668.2XP_024305436.1  protein unc-79 homolog isoform X20

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
      Conserved Domains (1) summary
      pfam14776
      Location:114583
      UNC-79; Cation-channel complex subunit UNC-79
    5. XM_017021515.2XP_016877004.1  protein unc-79 homolog isoform X18

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
    6. XM_047431627.1XP_047287583.1  protein unc-79 homolog isoform X24

    7. XM_011537018.3XP_011535320.1  protein unc-79 homolog isoform X1

      See identical proteins and their annotated locations for XP_011535320.1

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
      Conserved Domains (1) summary
      pfam14776
      Location:158690
      UNC-79; Cation-channel complex subunit UNC-79
    8. XM_017021507.2XP_016876996.1  protein unc-79 homolog isoform X4

      UniProtKB/TrEMBL
      G3V2U4
    9. XM_011537022.3XP_011535324.1  protein unc-79 homolog isoform X6

      See identical proteins and their annotated locations for XP_011535324.1

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
      Conserved Domains (1) summary
      pfam14776
      Location:158690
      UNC-79; Cation-channel complex subunit UNC-79
    10. XM_017021508.2XP_016876997.1  protein unc-79 homolog isoform X5

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
    11. XM_017021514.2XP_016877003.1  protein unc-79 homolog isoform X17

      UniProtKB/TrEMBL
      G3V2U4
    12. XM_017021506.2XP_016876995.1  protein unc-79 homolog isoform X3

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
    13. XM_011537020.3XP_011535322.1  protein unc-79 homolog isoform X2

      See identical proteins and their annotated locations for XP_011535322.1

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
      Conserved Domains (1) summary
      pfam14776
      Location:158690
      UNC-79; Cation-channel complex subunit UNC-79
    14. XM_017021510.2XP_016876999.1  protein unc-79 homolog isoform X10

      UniProtKB/TrEMBL
      G3V2U4
    15. XM_017021513.2XP_016877002.1  protein unc-79 homolog isoform X12

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
    16. XM_017021516.2XP_016877005.1  protein unc-79 homolog isoform X21

      UniProtKB/TrEMBL
      G3V2U4
    17. XM_024449667.2XP_024305435.1  protein unc-79 homolog isoform X9

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
      Conserved Domains (1) summary
      pfam14776
      Location:159690
      UNC-79; Cation-channel complex subunit UNC-79
    18. XM_011537024.3XP_011535326.1  protein unc-79 homolog isoform X13

      See identical proteins and their annotated locations for XP_011535326.1

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
      Conserved Domains (1) summary
      pfam14776
      Location:158690
      UNC-79; Cation-channel complex subunit UNC-79
    19. XM_017021509.2XP_016876998.1  protein unc-79 homolog isoform X8

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
    20. XM_047431622.1XP_047287578.1  protein unc-79 homolog isoform X11

    21. XM_011537023.3XP_011535325.1  protein unc-79 homolog isoform X7

      See identical proteins and their annotated locations for XP_011535325.1

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
      Conserved Domains (1) summary
      pfam07964
      Location:15392012
      Red1; Rec10 / Red1
    22. XM_047431625.1XP_047287581.1  protein unc-79 homolog isoform X19

    23. XM_047431623.1XP_047287579.1  protein unc-79 homolog isoform X14

    24. XM_017021517.2XP_016877006.1  protein unc-79 homolog isoform X25

      UniProtKB/TrEMBL
      G3V2U4
    25. XM_047431626.1XP_047287582.1  protein unc-79 homolog isoform X23

    26. XM_011537025.3XP_011535327.1  protein unc-79 homolog isoform X16

      See identical proteins and their annotated locations for XP_011535327.1

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
      Conserved Domains (1) summary
      pfam14776
      Location:158690
      UNC-79; Cation-channel complex subunit UNC-79
    27. XM_017021518.2XP_016877007.1  protein unc-79 homolog isoform X26

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
    28. XM_011537029.3XP_011535331.1  protein unc-79 homolog isoform X28

      See identical proteins and their annotated locations for XP_011535331.1

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
      Conserved Domains (1) summary
      pfam14776
      Location:6277
      UNC-79; Cation-channel complex subunit UNC-79
    29. XM_017021519.2XP_016877008.1  protein unc-79 homolog isoform X27

      UniProtKB/Swiss-Prot
      B5MDL6, Q6ZUT7, Q9P2D8
    30. XM_017021520.2XP_016877009.1  protein unc-79 homolog isoform X29

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187601.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      447744..822438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329015.1XP_054184990.1  protein unc-79 homolog isoform X22

    2. XM_054329014.1XP_054184989.1  protein unc-79 homolog isoform X22

    3. XM_054329007.1XP_054184982.1  protein unc-79 homolog isoform X15

    4. XM_054329012.1XP_054184987.1  protein unc-79 homolog isoform X20

    5. XM_054329010.1XP_054184985.1  protein unc-79 homolog isoform X18

    6. XM_054329017.1XP_054184992.1  protein unc-79 homolog isoform X24

    7. XM_054328993.1XP_054184968.1  protein unc-79 homolog isoform X1

    8. XM_054328996.1XP_054184971.1  protein unc-79 homolog isoform X4

    9. XM_054328998.1XP_054184973.1  protein unc-79 homolog isoform X6

    10. XM_054328997.1XP_054184972.1  protein unc-79 homolog isoform X5

    11. XM_054329009.1XP_054184984.1  protein unc-79 homolog isoform X17

    12. XM_054328995.1XP_054184970.1  protein unc-79 homolog isoform X3

    13. XM_054328994.1XP_054184969.1  protein unc-79 homolog isoform X2

    14. XM_054329002.1XP_054184977.1  protein unc-79 homolog isoform X10

    15. XM_054329004.1XP_054184979.1  protein unc-79 homolog isoform X12

    16. XM_054329013.1XP_054184988.1  protein unc-79 homolog isoform X21

    17. XM_054329001.1XP_054184976.1  protein unc-79 homolog isoform X9

    18. XM_054329005.1XP_054184980.1  protein unc-79 homolog isoform X13

    19. XM_054329000.1XP_054184975.1  protein unc-79 homolog isoform X8

    20. XM_054329003.1XP_054184978.1  protein unc-79 homolog isoform X11

    21. XM_054328999.1XP_054184974.1  protein unc-79 homolog isoform X7

    22. XM_054329011.1XP_054184986.1  protein unc-79 homolog isoform X19

    23. XM_054329006.1XP_054184981.1  protein unc-79 homolog isoform X14

    24. XM_054329018.1XP_054184993.1  protein unc-79 homolog isoform X25

    25. XM_054329016.1XP_054184991.1  protein unc-79 homolog isoform X23

    26. XM_054329008.1XP_054184983.1  protein unc-79 homolog isoform X16

    27. XM_054329019.1XP_054184994.1  protein unc-79 homolog isoform X26

    28. XM_054329021.1XP_054184996.1  protein unc-79 homolog isoform X28

    29. XM_054329020.1XP_054184995.1  protein unc-79 homolog isoform X27

    30. XM_054329022.1XP_054184997.1  protein unc-79 homolog isoform X29

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      87565061..87935165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376484.1XP_054232459.1  protein unc-79 homolog isoform X22

    2. XM_054376483.1XP_054232458.1  protein unc-79 homolog isoform X22

    3. XM_054376476.1XP_054232451.1  protein unc-79 homolog isoform X15

    4. XM_054376481.1XP_054232456.1  protein unc-79 homolog isoform X20

    5. XM_054376479.1XP_054232454.1  protein unc-79 homolog isoform X18

    6. XM_054376486.1XP_054232461.1  protein unc-79 homolog isoform X24

    7. XM_054376462.1XP_054232437.1  protein unc-79 homolog isoform X1

    8. XM_054376465.1XP_054232440.1  protein unc-79 homolog isoform X4

    9. XM_054376467.1XP_054232442.1  protein unc-79 homolog isoform X6

    10. XM_054376466.1XP_054232441.1  protein unc-79 homolog isoform X5

    11. XM_054376478.1XP_054232453.1  protein unc-79 homolog isoform X17

    12. XM_054376464.1XP_054232439.1  protein unc-79 homolog isoform X3

    13. XM_054376463.1XP_054232438.1  protein unc-79 homolog isoform X2

    14. XM_054376471.1XP_054232446.1  protein unc-79 homolog isoform X10

    15. XM_054376473.1XP_054232448.1  protein unc-79 homolog isoform X12

    16. XM_054376482.1XP_054232457.1  protein unc-79 homolog isoform X21

    17. XM_054376470.1XP_054232445.1  protein unc-79 homolog isoform X9

    18. XM_054376474.1XP_054232449.1  protein unc-79 homolog isoform X13

    19. XM_054376469.1XP_054232444.1  protein unc-79 homolog isoform X8

    20. XM_054376472.1XP_054232447.1  protein unc-79 homolog isoform X11

    21. XM_054376468.1XP_054232443.1  protein unc-79 homolog isoform X7

    22. XM_054376480.1XP_054232455.1  protein unc-79 homolog isoform X19

    23. XM_054376475.1XP_054232450.1  protein unc-79 homolog isoform X14

    24. XM_054376487.1XP_054232462.1  protein unc-79 homolog isoform X25

    25. XM_054376485.1XP_054232460.1  protein unc-79 homolog isoform X23

    26. XM_054376477.1XP_054232452.1  protein unc-79 homolog isoform X16

    27. XM_054376488.1XP_054232463.1  protein unc-79 homolog isoform X26

    28. XM_054376490.1XP_054232465.1  protein unc-79 homolog isoform X28

    29. XM_054376489.1XP_054232464.1  protein unc-79 homolog isoform X27

    30. XM_054376491.1XP_054232466.1  protein unc-79 homolog isoform X29