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    ADGRG3 adhesion G protein-coupled receptor G3 [ Homo sapiens (human) ]

    Gene ID: 222487, updated on 27-Nov-2024

    Summary

    Official Symbol
    ADGRG3provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor G3provided by HGNC
    Primary source
    HGNC:HGNC:13728
    See related
    Ensembl:ENSG00000182885 MIM:618441; AllianceGenome:HGNC:13728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PB99; GPR97; PGR26
    Summary
    Predicted to enable G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and regulation of cell migration. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bone marrow (RPKM 59.0), appendix (RPKM 9.5) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADGRG3 in Genome Data Viewer
    Location:
    16q21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57665629..57689378)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63460829..63484584)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57702218..57723290)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10904 Neighboring gene high mobility group box 3 pseudogene 32 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10905 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57653277-57653781 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57653782-57654285 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57654286-57654790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57656181-57657035 Neighboring gene Sharpr-MPRA regulatory region 10529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57661723-57662378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57662379-57663034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57665003-57665658 Neighboring gene adhesion G protein-coupled receptor G1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:57685116-57685516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57692922-57693920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57693921-57694919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57710685-57711625 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10909 Neighboring gene dynein regulatory complex subunit 7 Neighboring gene MTCH2 pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57767533-57768510 Neighboring gene uncharacterized LOC107984852 Neighboring gene Sharpr-MPRA regulatory region 7942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7536 Neighboring gene katanin regulatory subunit B1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    adhesion G protein-coupled receptor G3
    Names
    G protein-coupled receptor 97
    G-protein coupled receptor PGR26
    probable G-protein coupled receptor 97

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308360.2NP_001295289.1  adhesion G protein-coupled receptor G3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR and 5' coding region resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC018552, AK172801, AK301258, BC044222
      Consensus CDS
      CCDS76879.1
      UniProtKB/TrEMBL
      B4DVW2, F8W8F7
      Related
      ENSP00000404803.3, ENST00000450388.7
      Conserved Domains (2) summary
      pfam01825
      Location:93135
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:148397
      7tm_4; Olfactory receptor
    2. NM_170776.5NP_740746.4  adhesion G protein-coupled receptor G3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_740746.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC018552, BC064508, BE672513
      Consensus CDS
      CCDS10786.1
      UniProtKB/Swiss-Prot
      Q6ZMF4, Q86SL9, Q86Y34, Q8IZF1
      Related
      ENSP00000332900.4, ENST00000333493.9
      Conserved Domains (2) summary
      pfam01825
      Location:213255
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:268517
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      57665629..57689378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433780.1XP_047289736.1  adhesion G protein-coupled receptor G3 isoform X2

    2. XM_005255842.5XP_005255899.1  adhesion G protein-coupled receptor G3 isoform X1

      Conserved Domains (2) summary
      pfam01825
      Location:213255
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:355564
      7tm_4; Olfactory receptor
    3. XM_011522953.4XP_011521255.1  adhesion G protein-coupled receptor G3 isoform X4

      Conserved Domains (2) summary
      pfam01825
      Location:213255
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:274392
      7tm_4; Olfactory receptor
    4. XM_006721170.5XP_006721233.1  adhesion G protein-coupled receptor G3 isoform X6

      Conserved Domains (1) summary
      pfam01825
      Location:213255
      GPS; GPCR proteolysis site, GPS, motif
    5. XM_011522954.3XP_011521256.1  adhesion G protein-coupled receptor G3 isoform X5

      Conserved Domains (1) summary
      pfam01825
      Location:213255
      GPS; GPCR proteolysis site, GPS, motif
    6. XM_047433782.1XP_047289738.1  adhesion G protein-coupled receptor G3 isoform X7

      UniProtKB/TrEMBL
      H3BRU4
      Related
      ENSP00000456409.1, ENST00000567991.5
    7. XM_047433783.1XP_047289739.1  adhesion G protein-coupled receptor G3 isoform X8

    8. XM_047433781.1XP_047289737.1  adhesion G protein-coupled receptor G3 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      63460829..63484584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379819.1XP_054235794.1  adhesion G protein-coupled receptor G3 isoform X2

    2. XM_054379818.1XP_054235793.1  adhesion G protein-coupled receptor G3 isoform X1

    3. XM_054379821.1XP_054235796.1  adhesion G protein-coupled receptor G3 isoform X4

    4. XM_054379823.1XP_054235798.1  adhesion G protein-coupled receptor G3 isoform X6

    5. XM_054379822.1XP_054235797.1  adhesion G protein-coupled receptor G3 isoform X5

    6. XM_054379824.1XP_054235799.1  adhesion G protein-coupled receptor G3 isoform X7

      UniProtKB/TrEMBL
      H3BRU4
    7. XM_054379825.1XP_054235800.1  adhesion G protein-coupled receptor G3 isoform X8

    8. XM_054379820.1XP_054235795.1  adhesion G protein-coupled receptor G3 isoform X3