ADORA2B adenosine A2b receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADORA2Bprovided by HGNC
Official Full Name: adenosine A2b receptorprovided by HGNC
Primary source: HGNC:HGNC:264
See related: Ensembl:ENSG00000170425 MIM:600446; AllianceGenome:HGNC:264
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ADORA2
Summary: This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Expression: Broad expression in colon (RPKM 1.7), placenta (RPKM 1.2) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (15850362..15975746)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (15756782..15877924)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (15848444..15879060)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of Cannabinoid Receptors and Adenosine A2B Receptor in Enhanced Migration of Lung Cancer A549 Cells Induced by gamma-Ray Irradiation.
Title: Involvement of Cannabinoid Receptors and Adenosine A2B Receptor in Enhanced Migration of Lung Cancer A549 Cells Induced by γ-Ray Irradiation.
The resurgence of the Adora2b receptor as an immunotherapeutic target in pancreatic cancer.
Title: The resurgence of the Adora2b receptor as an immunotherapeutic target in pancreatic cancer.
CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer.
Title: CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer.
Adenosine Receptor A2B Negatively Regulates Cell Migration in Ovarian Carcinoma Cells.
Title: Adenosine Receptor A2B Negatively Regulates Cell Migration in Ovarian Carcinoma Cells.
Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.
Title: Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.
Tumor-derived exosomes promote angiogenesis via adenosine A2B receptor signaling.
Title: Tumor-derived exosomes promote angiogenesis via adenosine A(2B) receptor signaling.
Involvement of CD73 and A2B Receptor in Radiation-Induced DNA Damage Response and Cell Migration in Human Glioblastoma A172 Cells.
Title: Involvement of CD73 and A2B Receptor in Radiation-Induced DNA Damage Response and Cell Migration in Human Glioblastoma A172 Cells.
Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/beta-Catenin Pathway Stimulation by Regulating GSK3b Activity.
Title: Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/β-Catenin Pathway Stimulation by Regulating GSK3b Activity.
Systematic deletion of adenosine receptors reveals novel roles in inflammation and pyroptosis in THP-1 macrophages.
Title: Systematic deletion of adenosine receptors reveals novel roles in inflammation and pyroptosis in THP-1 macrophages.
Insulin requires A2B adenosine receptors to modulate the L-arginine/nitric oxide signalling in the human fetoplacental vascular endothelium from late-onset preeclampsia.
Title: Insulin requires A(2B) adenosine receptors to modulate the L-arginine/nitric oxide signalling in the human fetoplacental vascular endothelium from late-onset preeclampsia.

Submit: New GeneRIF Correction See all GeneRIFs (115)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S1679 (e-PCR)
- UniSTS:68876

SHGC-82711 (e-PCR)
- UniSTS:102421

STS-X68487 (e-PCR)
- UniSTS:7593

ADORA2B (e-PCR)
- UniSTS:480204

GDB:593101 (e-PCR)
- UniSTS:157937

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled adenosine receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in activation of adenylate cyclase activity	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in mast cell degranulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chronic inflammatory response to non-antigenic stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mast cell degranulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor production	IEA Inferred from Electronic Annotation more info
involved_in presynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in relaxation of vascular associated smooth muscle	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenosine receptor A2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000676.4 → NP_000667.1 adenosine receptor A2b

See identical proteins and their annotated locations for NP_000667.1

Status: VALIDATED

Source sequence(s)

AC006251

Consensus CDS

CCDS11173.1

UniProtKB/Swiss-Prot

P29275

Related

ENSP00000304501.2, ENST00000304222.3

Conserved Domains (1) summary

cd15069
Location:8 → 301

7tmA_Adenosine_R_A2B; adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

15850362..15975746

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047435373.1 → XP_047291329.1 adenosine receptor A2b isoform X2
XM_047435374.1 → XP_047291330.1 adenosine receptor A2b isoform X2
XM_011523659.4 → XP_011521961.1 adenosine receptor A2b isoform X2

Conserved Domains (1) summary

pfam00001
Location:6 → 187

7tm_1; 7 transmembrane receptor (rhodopsin family)
XM_047435375.1 → XP_047291331.1 adenosine receptor A2b isoform X3
XM_011523661.3 → XP_011521963.1 adenosine receptor A2b isoform X4

Conserved Domains (2) summary

cd14964
Location:10 → 34

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:8 → 112

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_017024197.3 → XP_016879686.1 adenosine receptor A2b isoform X1