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    EIF5A eukaryotic translation initiation factor 5A [ Homo sapiens (human) ]

    Gene ID: 1984, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EIF5Aprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 5Aprovided by HGNC
    Primary source
    HGNC:HGNC:3300
    See related
    Ensembl:ENSG00000132507 MIM:600187; AllianceGenome:HGNC:3300
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FABAS; EIF-5A; EIF5A1; eIF-4D; eIF5AI
    Summary
    Enables U6 snRNA binding activity. Involved in several processes, including cellular response to virus; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and tumor necrosis factor-mediated signaling pathway. Located in annulate lamellae; cytoplasm; and nucleus. Part of nuclear pore. Biomarker of colorectal cancer. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in esophagus (RPKM 53.8), appendix (RPKM 49.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EIF5A in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7306999..7312463)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7210983..7216447)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7210318..7215782)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Y-box binding protein 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:7197310-7197485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8102 Neighboring gene uncharacterized LOC124903912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8103 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11608 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:7209261-7210072 and GRCh37_chr17:7210073-7210883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8105 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8107 Neighboring gene G protein pathway suppressor 2 Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7226660-7227166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7227167-7227672 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7231927-7232586 Neighboring gene Sharpr-MPRA regulatory region 1992

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Prognostic significance and therapeutic potential of eukaryotic translation initiation factor 5A (eIF5A) in hepatocellular carcinoma. Lee NP, et al. Int J Cancer, 2010 Aug 15. PMID 19998337
    2. Blocking eIF5A modification in cervical cancer cells alters the expression of cancer-related genes and suppresses cell proliferation. Mémin E, et al. Cancer Res, 2014 Jan 15. PMID 24220243, Free PMC Article
    3. Down-regulation of eIF5A-2 prevents epithelial-mesenchymal transition in non-small-cell lung cancer cells. Xu GD, et al. J Zhejiang Univ Sci B, 2013 Jun. PMID 23733422, Free PMC Article
    4. Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress. Melis N, et al. Cells, 2023 Jan 25. PMID 36766751, Free PMC Article
    5. Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection. Manjunath H, et al. Cell Rep, 2019 Dec 3. PMID 31801078, Free PMC Article

    See all (243) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Insights into eukaryotic translation initiation factor 5A: Its role and mechanisms in protein synthesis.
      Title: Insights into eukaryotic translation initiation factor 5A: Its role and mechanisms in protein synthesis.
    2. Construction of a nomogram for predicting HNSCC distant metastasis and identification of EIF5A as a hub gene.
      Title: Construction of a nomogram for predicting HNSCC distant metastasis and identification of EIF5A as a hub gene.
    3. AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.
      Title: AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.
    4. Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.
      Title: Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.
    5. Targeted inhibition of eIF5A[hpu] suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer.
      Title: Targeted inhibition of eIF5A(hpu) suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer.
    6. High levels of hypusinated eIF5A in leiomyoma and leiomyosarcoma pathologies: a possible novel therapeutic target.
      Title: High levels of hypusinated eIF5A in leiomyoma and leiomyosarcoma pathologies: a possible novel therapeutic target.
    7. Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration.
      Title: Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration.
    8. Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
      Title: Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
    9. Comparison of Human Eukaryotic Translation Initiation Factors 5A1 and 5AL1: Identification of Amino Acid Residues Important for EIF5A1 Lysine 50 Hypusination and Its Protein Stability.
      Title: Comparison of Human Eukaryotic Translation Initiation Factors 5A1 and 5AL1: Identification of Amino Acid Residues Important for EIF5A1 Lysine 50 Hypusination and Its Protein Stability.
    10. Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
      Title: Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
    Submit: New GeneRIF Correction See all GeneRIFs (77)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Faundes-Banka syndrome
    MedGen: C5543554 OMIM: 619376 GeneReviews: Not available
    		not available

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef downregulates the expression of eukaryotic translation initiation factor 5A (EIF5A) protein in Nef-transfected SupT1 cells PubMed
    Rev rev eIF-5A binds Rev Response Element (RRE) RNA, an interaction likely to be involved in its association with Rev during nuclear export PubMed
    rev eIF-5A directly interacts with CRM1 and mediates its binding to Rev, an effect that is required for nuclear export of Rev PubMed
    rev eIF-5A is a hypusine-containing protein required for Rev-mediated nuclear export of HIV-1 mRNA PubMed
    rev eIF-5A interacts with the ribosomal protein L5 during its Rev nuclear export activity PubMed
    rev eIF-5A interacts with nucleoporins CAN/nup214, nup153, nup98, and nup62 as well as nuclear actin during the nuclear export of Rev PubMed
    rev eIF-5A interacts with the activation domain of Rev (amino acids 75-83) PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human eukaryotic translation initiation factor 5A (EIF5A) at amino acid residues 5-6, 96-97, 97-98, and 100-101 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC99547, MGC104255

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables U6 snRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translational elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of translational termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in annulate lamellae IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 5A-1
    Names
    eukaryotic initiation factor 5A
    rev-binding factor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143760.1 → NP_001137232.1  eukaryotic translation initiation factor 5A-1 isoform A

      See identical proteins and their annotated locations for NP_001137232.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) encodes the longer isoform (A).
      Source sequence(s)
      AC026954, AY129319
      Consensus CDS
      CCDS45601.1
      UniProtKB/TrEMBL
      I3L504
      Related
      ENSP00000336702.7, ENST00000336452.11
      Conserved Domains (1) summary
      cl28432
      Location:31 → 180
      PRK03999; translation initiation factor IF-5A; Provisional

    2. NM_001143761.1 → NP_001137233.1  eukaryotic translation initiation factor 5A-1 isoform B

      See identical proteins and their annotated locations for NP_001137233.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (C) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant A. The encoded isoform (B) has a shorter N-terminus compared to isoform A. Variants B, C, and D encode the same isoform.
      Source sequence(s)
      AC026954, AY129321
      Consensus CDS
      CCDS11099.1
      UniProtKB/Swiss-Prot
      A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2
      UniProtKB/TrEMBL
      I3L397
      Related
      ENSP00000390677.2, ENST00000419711.6
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    3. NM_001143762.2 → NP_001137234.1  eukaryotic translation initiation factor 5A-1 isoform B

      See identical proteins and their annotated locations for NP_001137234.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (D) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant A. The encoded isoform (B) has a shorter N-terminus compared to isoform A. Variants B, C, and D encode the same isoform.
      Source sequence(s)
      AC026954, AY129322, BG479628
      Consensus CDS
      CCDS11099.1
      UniProtKB/Swiss-Prot
      A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2
      UniProtKB/TrEMBL
      I3L397
      Related
      ENSP00000396073.2, ENST00000416016.2
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    4. NM_001370420.1 → NP_001357349.1  eukaryotic translation initiation factor 5A-1 isoform B

      Status: VALIDATED

      Source sequence(s)
      AC026954
      Consensus CDS
      CCDS11099.1
      UniProtKB/Swiss-Prot
      A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2
      UniProtKB/TrEMBL
      I3L397
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    5. NM_001370421.1 → NP_001357350.1  eukaryotic translation initiation factor 5A-1 isoform B

      Status: VALIDATED

      Source sequence(s)
      AC026954
      Consensus CDS
      CCDS11099.1
      UniProtKB/Swiss-Prot
      A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2
      UniProtKB/TrEMBL
      I3L397
      Related
      ENSP00000460284.1, ENST00000573714.5
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    6. NM_001970.5 → NP_001961.1  eukaryotic translation initiation factor 5A-1 isoform B

      See identical proteins and their annotated locations for NP_001961.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant A. The encoded isoform (B) has a shorter N-terminus compared to isoform A. Variants B, C, and D encode the same isoform.
      Source sequence(s)
      AC026954, AY129320, CB111036
      Consensus CDS
      CCDS11099.1
      UniProtKB/Swiss-Prot
      A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2
      UniProtKB/TrEMBL
      I3L397
      Related
      ENSP00000336776.8, ENST00000336458.13
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      7306999..7312463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024301.3 → XP_016879790.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/TrEMBL
      B7Z8F1

    2. XM_047435523.1 → XP_047291479.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/TrEMBL
      B7Z8F1

    3. XM_011523710.3 → XP_011522012.1  eukaryotic translation initiation factor 5A-1 isoform X1

      See identical proteins and their annotated locations for XP_011522012.1

      UniProtKB/TrEMBL
      B7Z8F1

    4. XM_011523712.4 → XP_011522014.1  eukaryotic translation initiation factor 5A-1 isoform X1

      See identical proteins and their annotated locations for XP_011522014.1

      UniProtKB/TrEMBL
      B7Z8F1

    5. XM_011523711.3 → XP_011522013.1  eukaryotic translation initiation factor 5A-1 isoform X1

      See identical proteins and their annotated locations for XP_011522013.1

      UniProtKB/TrEMBL
      B7Z8F1

    6. XM_047435524.1 → XP_047291480.1  eukaryotic translation initiation factor 5A-1 isoform X2

      UniProtKB/Swiss-Prot
      A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2
      UniProtKB/TrEMBL
      I3L397

    7. XM_011523713.3 → XP_011522015.1  eukaryotic translation initiation factor 5A-1 isoform X1

      See identical proteins and their annotated locations for XP_011522015.1

      UniProtKB/TrEMBL
      B7Z8F1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160020.1 Reference GRCh38.p14 PATCHES

      Range
      65364..70828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332651.1 → XP_054188626.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/TrEMBL
      B7Z8F1

    2. XM_054332647.1 → XP_054188622.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/TrEMBL
      B7Z8F1

    3. XM_054332648.1 → XP_054188623.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/TrEMBL
      B7Z8F1

    4. XM_054332649.1 → XP_054188624.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/TrEMBL
      B7Z8F1

    5. XM_054332652.1 → XP_054188627.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/TrEMBL
      B7Z8F1

    6. XM_054332650.1 → XP_054188625.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/TrEMBL
      B7Z8F1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      7210983..7216447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315317.1 → XP_054171292.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/TrEMBL
      B7Z8F1

    2. XM_054315313.1 → XP_054171288.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/TrEMBL
      B7Z8F1

    3. XM_054315314.1 → XP_054171289.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/TrEMBL
      B7Z8F1

    4. XM_054315315.1 → XP_054171290.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/TrEMBL
      B7Z8F1

    5. XM_054315318.1 → XP_054171293.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/TrEMBL
      B7Z8F1

    6. XM_054315316.1 → XP_054171291.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/TrEMBL
      B7Z8F1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63241.2 GenPept UniProtKB/Swiss-Prot:P63241

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