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    KSR1 kinase suppressor of ras 1 [ Homo sapiens (human) ]

    Gene ID: 8844, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KSR1provided by HGNC
    Official Full Name
    kinase suppressor of ras 1provided by HGNC
    Primary source
    HGNC:HGNC:6465
    See related
    Ensembl:ENSG00000141068 MIM:601132; AllianceGenome:HGNC:6465
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KSR; RSU2
    Summary
    Enables 14-3-3 protein binding activity and ATP binding activity. Involved in positive regulation of MAPK cascade. Located in cytosol; endoplasmic reticulum; and membrane. Part of protein-containing complex. Implicated in breast adenocarcinoma. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 8.2), endometrium (RPKM 5.8) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KSR1 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (27456448..27626435)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (28397924..28567909)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (25783474..25953461)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371705 Neighboring gene TBC1 domain family member 3 pseudogene 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:25783139-25783640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25787154-25787857 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25788561-25789264 Neighboring gene Sharpr-MPRA regulatory region 12448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11901 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25798863-25799627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25799628-25800392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11903 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25802427-25802940 Neighboring gene Sharpr-MPRA regulatory region 12304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25806167-25806668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11905 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:25830813-25832012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25833398-25833995 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25838597-25839125 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25840412-25841256 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25841257-25842099 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25846538-25847174 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:25859917-25860102 Neighboring gene MSANTD3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25865210-25866051 Neighboring gene uncharacterized LOC124903960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25867223-25868022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25869832-25870332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25870333-25870833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25894115-25895067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25896821-25897581 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25917327-25917828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25917829-25918328 Neighboring gene integral membrane protein 2B pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25957839-25958656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25964969-25965523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25970104-25970797 Neighboring gene galectin 9 Neighboring gene nitric oxide synthase 2 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras. Xing HR, et al. J Biol Chem, 2000 Jun 9. PMID 10764733
    2. Inflammatory bowel disease reveals the kinase activity of KSR1. Kolesnick R, et al. J Clin Invest, 2004 Nov. PMID 15520853, Free PMC Article
    3. Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity. Kim M, et al. Cancer Res, 2005 May 15. PMID 15899786
    4. Induction of kinase suppressor of RAS-1(KSR-1) gene by 1, alpha25-dihydroxyvitamin D3 in human leukemia HL60 cells through a vitamin D response element in the 5'-flanking region. Wang X, et al. Oncogene, 2006 Nov 9. PMID 16732322, Free PMC Article
    5. Genetic variants of kinase suppressors of Ras (KSR1) to predict survival in patients with ERα-positive advanced breast cancer. Benhaim L, et al. Pharmacogenomics J, 2015 Jun. PMID 25287073

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status.
      Title: SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status.
    2. Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells.
      Title: Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells.
    3. SHP2 inhibition mitigates adaptive resistance to MEK inhibitors in KRAS-mutant gastric cancer through the suppression of KSR1 activity.
      Title: SHP2 inhibition mitigates adaptive resistance to MEK inhibitors in KRAS-mutant gastric cancer through the suppression of KSR1 activity.
    4. Praja2 suppresses the growth of gastric cancer by ubiquitylation of KSR1 and inhibiting MEK-ERK signal pathways.
      Title: Praja2 suppresses the growth of gastric cancer by ubiquitylation of KSR1 and inhibiting MEK-ERK signal pathways.
    5. Findings demonstrate a role for kinase suppressor of Ras 1 as a positive regulator of neurotensin secretion from human endocrine cells and indicate that this effect is mediated by the extracellular signal-regulated kinase 1 and 2 signaling pathway.
      Title: Kinase suppressor of Ras 1 and Exo70 promote fatty acid-stimulated neurotensin secretion through ERK1/2 signaling.
    6. Erbin interacted with kinase suppressor of Ras 1 (KSR1) and displaced it from the RAF/MEK/ERK complex to prevent signal propagation..These findings establish the scaffold protein Erbin as a negative regulator of EMT and tumorigenesis in colorectal cancer through direct suppression of Akt and RAS/RAF signaling
      Title: Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer.
    7. findings demonstrate that KSR-MEK complexes allosterically activate BRAF through the action of N-terminal regulatory region and kinase domain contacts and challenge the accepted role of KSR as a scaffold for MEK recruitment to RAF
      Title: MEK drives BRAF activation through allosteric control of KSR proteins.
    8. Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer
      Title: Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer.
    9. praja2 regulates KSR1 stability and mitogenic signaling.
      Title: praja2 regulates KSR1 stability and mitogenic signaling.
    10. Data show that neurofibromin 2 (Merlin) suppresses proliferation and adhesion, at least partly, through inhibiting kinase suppressor of Ras 1 (KSR1) and DCAF1 protein.
      Title: The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP-kinase scaffold activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in Ras protein signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinase suppressor of Ras 1
    NP_001354739.1
    NP_001381512.1
    NP_001381513.1
    NP_001381514.1
    NP_055053.1
    XP_006722217.1
    XP_011523731.1
    XP_011523733.1
    XP_016880768.1
    XP_016880769.1
    XP_047292941.1
    XP_047292942.1
    XP_047292943.1
    XP_047292944.1
    XP_047292945.1
    XP_047292946.1
    XP_047292947.1
    XP_047292948.1
    XP_047292949.1
    XP_047292950.1
    XP_047292951.1
    XP_047292952.1
    XP_054173639.1
    XP_054173640.1
    XP_054173641.1
    XP_054173642.1
    XP_054173643.1
    XP_054173644.1
    XP_054173645.1
    XP_054173646.1
    XP_054173647.1
    XP_054173648.1
    XP_054173649.1
    XP_054173650.1
    XP_054173651.1
    XP_054173652.1
    XP_054173653.1
    XP_054173654.1
    XP_054173655.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001367810.1 → NP_001354739.1  kinase suppressor of Ras 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC015688, AC069366
      UniProtKB/TrEMBL
      A0A2R8Y4X0
      Conserved Domains (3) summary
      cd14152
      Location:590 → 868
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:41 → 168
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
      cd20872
      Location:346 → 392
      C1_KSR1; protein kinase C conserved region 1 (C1 domain) found in kinase suppressor of Ras 1 (KSR1) and similar proteins

    2. NM_001394583.1 → NP_001381512.1  kinase suppressor of Ras 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC015688, AC069366
      Consensus CDS
      CCDS92281.1
      UniProtKB/TrEMBL
      A0A2R8Y4X0, A0A2R8Y5H9
      Related
      ENSP00000494552.1, ENST00000644974.2
      Conserved Domains (2) summary
      smart00109
      Location:348 → 390
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd14152
      Location:590 → 868
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1

    3. NM_001394584.1 → NP_001381513.1  kinase suppressor of Ras 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC015688, AC069366
      UniProtKB/TrEMBL
      A8MY87
      Conserved Domains (2) summary
      smart00109
      Location:12 → 54
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd14152
      Location:254 → 532
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1

    4. NM_001394585.1 → NP_001381514.1  kinase suppressor of Ras 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC015688, AC069366
      UniProtKB/TrEMBL
      A8MY87
      Conserved Domains (2) summary
      smart00109
      Location:12 → 54
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd14152
      Location:240 → 518
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1

    5. NM_014238.2 → NP_055053.1  kinase suppressor of Ras 1 isoform 1

      See identical proteins and their annotated locations for NP_055053.1

      Status: VALIDATED

      Source sequence(s)
      AC015688, AC069366, BC037586, BC042106, BI829205, BX396814, U43586
      Consensus CDS
      CCDS58532.1
      UniProtKB/TrEMBL
      A0A2R8Y4X0
      Related
      ENSP00000381958.3, ENST00000398988.7
      Conserved Domains (3) summary
      cd00029
      Location:211 → 253
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:475 → 753
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam07714
      Location:476 → 740
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      27456448..27626435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436989.1 → XP_047292945.1  kinase suppressor of Ras 1 isoform X8

      UniProtKB/TrEMBL
      A0A2R8Y4X0

    2. XM_047436985.1 → XP_047292941.1  kinase suppressor of Ras 1 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y4X0

    3. XM_011525429.3 → XP_011523731.1  kinase suppressor of Ras 1 isoform X2

      See identical proteins and their annotated locations for XP_011523731.1

      UniProtKB/Swiss-Prot
      F8WEA9, H7BYU0, Q13476, Q8IVT5
      UniProtKB/TrEMBL
      A0A2R8Y4X0
      Conserved Domains (3) summary
      cd14152
      Location:612 → 890
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:41 → 168
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
      cd20872
      Location:346 → 392
      C1_KSR1; protein kinase C conserved region 1 (C1 domain) found in kinase suppressor of Ras 1 (KSR1) and similar proteins

    4. XM_047436986.1 → XP_047292942.1  kinase suppressor of Ras 1 isoform X3

      UniProtKB/TrEMBL
      A0A2R8Y4X0

    5. XM_006722154.4 → XP_006722217.1  kinase suppressor of Ras 1 isoform X5

      See identical proteins and their annotated locations for XP_006722217.1

      UniProtKB/TrEMBL
      A0A2R8Y4X0
      Conserved Domains (4) summary
      cd00029
      Location:348 → 390
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:576 → 854
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam07714
      Location:577 → 841
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13543
      Location:41 → 168
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

    6. XM_047436987.1 → XP_047292943.1  kinase suppressor of Ras 1 isoform X6

      UniProtKB/TrEMBL
      A0A2R8Y4X0

    7. XM_047436988.1 → XP_047292944.1  kinase suppressor of Ras 1 isoform X7

      UniProtKB/TrEMBL
      A0A2R8Y4X0

    8. XM_011525431.3 → XP_011523733.1  kinase suppressor of Ras 1 isoform X4

      UniProtKB/TrEMBL
      A0A2R8Y4X0
      Conserved Domains (4) summary
      cd00029
      Location:348 → 390
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:612 → 890
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam07714
      Location:613 → 877
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13543
      Location:41 → 168
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

    9. XM_017025280.3 → XP_016880769.1  kinase suppressor of Ras 1 isoform X14

    10. XM_017025279.2 → XP_016880768.1  kinase suppressor of Ras 1 isoform X12

    11. XM_047436991.1 → XP_047292947.1  kinase suppressor of Ras 1 isoform X8

      UniProtKB/TrEMBL
      A0A2R8Y4X0

    12. XM_047436990.1 → XP_047292946.1  kinase suppressor of Ras 1 isoform X8

      UniProtKB/TrEMBL
      A0A2R8Y4X0
      Related
      ENSP00000494039.1, ENST00000644418.1

    13. XM_047436993.1 → XP_047292949.1  kinase suppressor of Ras 1 isoform X9

      UniProtKB/TrEMBL
      A8MY87

    14. XM_047436995.1 → XP_047292951.1  kinase suppressor of Ras 1 isoform X11

      UniProtKB/TrEMBL
      A8MY87

    15. XM_047436992.1 → XP_047292948.1  kinase suppressor of Ras 1 isoform X9

      UniProtKB/TrEMBL
      A8MY87

    16. XM_047436994.1 → XP_047292950.1  kinase suppressor of Ras 1 isoform X10

      UniProtKB/TrEMBL
      A8MY87

    17. XM_047436996.1 → XP_047292952.1  kinase suppressor of Ras 1 isoform X13

      UniProtKB/TrEMBL
      A8MY87
      Related
      ENSP00000381952.2, ENST00000398982.6

    RNA

    1. XR_934587.4 RNA Sequence

    2. XR_007065523.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      28397924..28567909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317671.1 → XP_054173646.1  kinase suppressor of Ras 1 isoform X8

      UniProtKB/TrEMBL
      A0A2R8Y4X0

    2. XM_054317664.1 → XP_054173639.1  kinase suppressor of Ras 1 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y4X0

    3. XM_054317665.1 → XP_054173640.1  kinase suppressor of Ras 1 isoform X2

      UniProtKB/Swiss-Prot
      F8WEA9, H7BYU0, Q13476, Q8IVT5
      UniProtKB/TrEMBL
      A0A2R8Y4X0

    4. XM_054317666.1 → XP_054173641.1  kinase suppressor of Ras 1 isoform X3

      UniProtKB/TrEMBL
      A0A2R8Y4X0

    5. XM_054317668.1 → XP_054173643.1  kinase suppressor of Ras 1 isoform X5

      UniProtKB/TrEMBL
      A0A2R8Y4X0

    6. XM_054317669.1 → XP_054173644.1  kinase suppressor of Ras 1 isoform X6

      UniProtKB/TrEMBL
      A0A2R8Y4X0

    7. XM_054317670.1 → XP_054173645.1  kinase suppressor of Ras 1 isoform X7

      UniProtKB/TrEMBL
      A0A2R8Y4X0

    8. XM_054317667.1 → XP_054173642.1  kinase suppressor of Ras 1 isoform X4

      UniProtKB/TrEMBL
      A0A2R8Y4X0

    9. XM_054317680.1 → XP_054173655.1  kinase suppressor of Ras 1 isoform X14

    10. XM_054317678.1 → XP_054173653.1  kinase suppressor of Ras 1 isoform X12

    11. XM_054317673.1 → XP_054173648.1  kinase suppressor of Ras 1 isoform X8

      UniProtKB/TrEMBL
      A0A2R8Y4X0

    12. XM_054317672.1 → XP_054173647.1  kinase suppressor of Ras 1 isoform X8

      UniProtKB/TrEMBL
      A0A2R8Y4X0

    13. XM_054317675.1 → XP_054173650.1  kinase suppressor of Ras 1 isoform X9

      UniProtKB/TrEMBL
      A8MY87

    14. XM_054317677.1 → XP_054173652.1  kinase suppressor of Ras 1 isoform X11

      UniProtKB/TrEMBL
      A8MY87

    15. XM_054317674.1 → XP_054173649.1  kinase suppressor of Ras 1 isoform X9

      UniProtKB/TrEMBL
      A8MY87

    16. XM_054317676.1 → XP_054173651.1  kinase suppressor of Ras 1 isoform X10

      UniProtKB/TrEMBL
      A8MY87

    17. XM_054317679.1 → XP_054173654.1  kinase suppressor of Ras 1 isoform X13

      UniProtKB/TrEMBL
      A8MY87

    RNA

    1. XR_008484960.1 RNA Sequence

    2. XR_008484961.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IVT5.3 GenPept UniProtKB/Swiss-Prot:Q8IVT5

    Gene LinkOut

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