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    RNMT RNA guanine-7 methyltransferase [ Homo sapiens (human) ]

    Gene ID: 8731, updated on 10-Dec-2024

    Summary

    Official Symbol
    RNMTprovided by HGNC
    Official Full Name
    RNA guanine-7 methyltransferaseprovided by HGNC
    Primary source
    HGNC:HGNC:10075
    See related
    Ensembl:ENSG00000101654 MIM:603514; AllianceGenome:HGNC:10075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MET; Met; CMT1; cm1p; hMet; CMT1c; hCMT1; RG7MT1; N7-MTase
    Summary
    Enables RNA binding activity and mRNA 5'-cap (guanine-N7-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in fibrillar center and nucleoplasm. Part of mRNA cap methyltransferase RNMT:RAMAC complex; mRNA capping enzyme complex; and receptor complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 9.8), thyroid (RPKM 9.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RNMT in Genome Data Viewer
    Location:
    18p11.21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (13726673..13764556)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (13888989..13926829)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (13726672..13764555)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13613273-13613792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13613793-13614310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13616337-13616838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13623209-13623708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13626114-13626614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13649057-13649558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13649559-13650058 Neighboring gene microRNA 4526 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:13672949-13674148 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:13675367-13676566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13688247-13688792 Neighboring gene family with sequence similarity 210 member A Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:13725735-13726660 Neighboring gene RNA, 7SL, cytoplasmic 362, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:13775047-13775546 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:13823817-13823997 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13834952-13835452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13872168-13873006 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:13876434-13877404 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr18:13878605-13879337 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13887335-13887847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9337 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13129 Neighboring gene melanocortin 5 receptor Neighboring gene melanocortin 2 receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0398, DKFZp686H1252

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in 7-methylguanosine mRNA capping IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in 7-methylguanosine mRNA capping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in 7-methylguanosine mRNA capping TAS
    Traceable Author Statement
    more info
     
    involved_in RNA 5'-cap (guanine-N7)-methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    part_of mRNA cap methyltransferase RNMT:RAMAC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mRNA capping enzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mRNA cap guanine-N(7) methyltransferase; mRNA cap guanine-N7 methyltransferase
    Names
    RNA (guanine-7-) methyltransferase
    hcm1p
    mRNA (guanine-7-)methyltransferase
    mRNA (guanine-N(7)-)-methyltransferase
    mRNA cap methyltransferase
    NP_001295192.1
    NP_001365061.1
    NP_001365063.1
    NP_001365064.1
    NP_003790.1
    XP_011524051.1
    XP_011524052.1
    XP_011524053.1
    XP_011524055.1
    XP_047293863.1
    XP_047293864.1
    XP_054175275.1
    XP_054175276.1
    XP_054175277.1
    XP_054175278.1
    XP_054175279.1
    XP_054175280.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308263.2NP_001295192.1  mRNA cap guanine-N(7) methyltransferase isoform 1

      See identical proteins and their annotated locations for NP_001295192.1

      Status: VALIDATED

      Source sequence(s)
      AB022605, AK292561, AP001525, DA634865
      Consensus CDS
      CCDS77156.1
      UniProtKB/TrEMBL
      A8K946
      Related
      ENSP00000466111.1, ENST00000592764.5
      Conserved Domains (1) summary
      pfam03291
      Location:136466
      Pox_MCEL; mRNA capping enzyme
    2. NM_001378132.1NP_001365061.1  mRNA cap guanine-N(7) methyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AP001525
      Consensus CDS
      CCDS92440.1
      UniProtKB/TrEMBL
      K7EP06
      Related
      ENSP00000467171.1, ENST00000588457.5
      Conserved Domains (1) summary
      cl17173
      Location:1297
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_001378134.1NP_001365063.1  mRNA cap guanine-N(7) methyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AP001525
      Consensus CDS
      CCDS77156.1
      UniProtKB/TrEMBL
      A8K946
      Conserved Domains (1) summary
      pfam03291
      Location:136466
      Pox_MCEL; mRNA capping enzyme
    4. NM_001378135.1NP_001365064.1  mRNA cap guanine-N(7) methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP001525
      Consensus CDS
      CCDS11867.1
      UniProtKB/Swiss-Prot
      B0YJ90, D3DUJ5, O43148, O94996, Q9UIJ9
      UniProtKB/TrEMBL
      A8K946
      Related
      ENSP00000446426.1, ENST00000543302.6
      Conserved Domains (1) summary
      pfam03291
      Location:136475
      Pox_MCEL; mRNA capping enzyme
    5. NM_003799.3NP_003790.1  mRNA cap guanine-N(7) methyltransferase isoform 2

      See identical proteins and their annotated locations for NP_003790.1

      Status: VALIDATED

      Source sequence(s)
      AB022605, AF067791, AP001525, DA634865
      Consensus CDS
      CCDS11867.1
      UniProtKB/Swiss-Prot
      B0YJ90, D3DUJ5, O43148, O94996, Q9UIJ9
      UniProtKB/TrEMBL
      A8K946
      Related
      ENSP00000372804.2, ENST00000383314.7
      Conserved Domains (1) summary
      pfam03291
      Location:136475
      Pox_MCEL; mRNA capping enzyme

    RNA

    1. NR_165427.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001525

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      13726673..13764556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047437908.1XP_047293864.1  mRNA cap guanine-N7 methyltransferase isoform X3

      UniProtKB/Swiss-Prot
      B0YJ90, D3DUJ5, O43148, O94996, Q9UIJ9
      UniProtKB/TrEMBL
      A8K946
    2. XM_047437907.1XP_047293863.1  mRNA cap guanine-N7 methyltransferase isoform X2

      UniProtKB/TrEMBL
      A8K946
    3. XM_011525749.3XP_011524051.1  mRNA cap guanine-N7 methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_011524051.1

      UniProtKB/TrEMBL
      A8K946
      Conserved Domains (2) summary
      COG0500
      Location:196414
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam03291
      Location:136468
      Pox_MCEL; mRNA capping enzyme
    4. XM_011525751.2XP_011524053.1  mRNA cap guanine-N7 methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_011524053.1

      UniProtKB/TrEMBL
      A8K946
      Conserved Domains (2) summary
      COG0500
      Location:196414
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam03291
      Location:136468
      Pox_MCEL; mRNA capping enzyme
    5. XM_011525750.3XP_011524052.1  mRNA cap guanine-N7 methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_011524052.1

      UniProtKB/TrEMBL
      A8K946
      Conserved Domains (2) summary
      COG0500
      Location:196414
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam03291
      Location:136468
      Pox_MCEL; mRNA capping enzyme
    6. XM_011525753.3XP_011524055.1  mRNA cap guanine-N7 methyltransferase isoform X4

      Conserved Domains (2) summary
      COG0500
      Location:18149
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      cl17173
      Location:1290
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      13888989..13926829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319300.1XP_054175275.1  mRNA cap guanine-N7 methyltransferase isoform X1

      UniProtKB/TrEMBL
      A8K946
    2. XM_054319301.1XP_054175276.1  mRNA cap guanine-N7 methyltransferase isoform X1

      UniProtKB/TrEMBL
      A8K946
    3. XM_054319305.1XP_054175280.1  mRNA cap guanine-N7 methyltransferase isoform X4

    4. XM_054319304.1XP_054175279.1  mRNA cap guanine-N7 methyltransferase isoform X3

      UniProtKB/Swiss-Prot
      B0YJ90, D3DUJ5, O43148, O94996, Q9UIJ9
      UniProtKB/TrEMBL
      A8K946
    5. XM_054319303.1XP_054175278.1  mRNA cap guanine-N7 methyltransferase isoform X2

      UniProtKB/TrEMBL
      A8K946
    6. XM_054319302.1XP_054175277.1  mRNA cap guanine-N7 methyltransferase isoform X1

      UniProtKB/TrEMBL
      A8K946