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    SHC2 SHC adaptor protein 2 [ Homo sapiens (human) ]

    Gene ID: 25759, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SHC2provided by HGNC
    Official Full Name
    SHC adaptor protein 2provided by HGNC
    Primary source
    HGNC:HGNC:29869
    See related
    Ensembl:ENSG00000129946 MIM:605217; AllianceGenome:HGNC:29869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCK; SLI; SHCB
    Summary
    Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 10.2), gall bladder (RPKM 9.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SHC2 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (416589..461033, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (364869..412538, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (416589..461033, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:406130-407009 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:407010-407890 Neighboring gene proline-rich proteoglycan 2-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:412911-413666 Neighboring gene C2 calcium dependent domain containing 4C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:427767-428344 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:428871-430070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:436243-436744 Neighboring gene RNA, 5S ribosomal pseudogene 462 Neighboring gene MPRA-validated peak3210 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:470349-470886 Neighboring gene CIMAP1 family member D Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:485653-486171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9600 Neighboring gene uncharacterized LOC124904608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:489477-489978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9602 Neighboring gene MADCAM1 antisense RNA 1 Neighboring gene mucosal vascular addressin cell adhesion molecule 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. Kavanaugh WM, et al. Science, 1994 Dec 16. PMID 7527937
    2. SHC2 gene copy number in multiple system atrophy (MSA). Ferguson MC, et al. Clin Auton Res, 2014 Feb. PMID 24170347, Free PMC Article
    3. Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy. Sasaki H, et al. Mol Brain, 2011 Jun 10. PMID 21658278, Free PMC Article
    4. CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma. Teodorczyk M, et al. Cell Death Differ, 2015 Jul. PMID 25613377, Free PMC Article
    5. Sck interacts with KDR and Flt-1 via its SH2 domain. Igarashi K, et al. Biochem Biophys Res Commun, 1998 Oct 9. PMID 9790910

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sck was identified as a novel molecule indispensable for CD95's activation of the PI3K and MAPK pathways and induction of cell cycle progression in pancreatic ductal adenocarcinoma.
      Title: CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma.
    2. SHC2 gene deletions underlie few, if any, cases of well-characterized multiple system atrophy in the US population.
      Title: SHC2 gene copy number in multiple system atrophy (MSA).
    3. Data show that copy number loss of SHC2 strongly indicates a causal link to multiple system atrophy.
      Title: Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat-induced small GTPase Ras activation is mediated by tyrosine phosphorylation of Shc and recruitment of Grb2 in human endothelial cells PubMed
    tat HIV-1 Tat activates the MAPK signaling pathway leading to the phosphorylation of Shc, a protein involved in signal transduction downstream of receptor tyrosine kinase activation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SHC-transforming protein 2
    Names
    SH2 domain protein C2
    SHC (Src homology 2 domain containing) transforming protein 2
    SHC-transforming protein B
    neuronal Shc adaptor homolog
    protein Sck
    src homology 2 domain-containing-transforming protein C2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001387056.1 → NP_001373985.1  SHC-transforming protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC006124, AC008988, AC138433
      Conserved Domains (2) summary
      cd09925
      Location:434 → 537
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:138 → 307
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    2. NM_012435.3 → NP_036567.2  SHC-transforming protein 2 isoform 1

      See identical proteins and their annotated locations for NP_036567.2

      Status: VALIDATED

      Source sequence(s)
      AC006124, AC008988, AC138433
      Consensus CDS
      CCDS45891.1
      UniProtKB/Swiss-Prot
      O60230, P98077, Q9NPL5, Q9UCX4
      Related
      ENSP00000264554.4, ENST00000264554.11
      Conserved Domains (2) summary
      cd09925
      Location:479 → 582
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:138 → 307
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      416589..461033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527894.3 → XP_011526196.1  SHC-transforming protein 2 isoform X2

      Conserved Domains (2) summary
      cd01209
      Location:138 → 307
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
      cl15255
      Location:434 → 497
      SH2; Src homology 2 (SH2) domain

    2. XM_011527893.4 → XP_011526195.1  SHC-transforming protein 2 isoform X1

      Conserved Domains (2) summary
      cd01209
      Location:138 → 307
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
      cl15255
      Location:479 → 542
      SH2; Src homology 2 (SH2) domain

    3. XM_011527896.3 → XP_011526198.1  SHC-transforming protein 2 isoform X3

      Conserved Domains (2) summary
      cd01209
      Location:1 → 150
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
      cl15255
      Location:322 → 385
      SH2; Src homology 2 (SH2) domain

    4. XM_047438565.1 → XP_047294521.1  SHC-transforming protein 2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      364869..412538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320469.1 → XP_054176444.1  SHC-transforming protein 2 isoform X4

    2. XM_054320470.1 → XP_054176445.1  SHC-transforming protein 2 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98077.4 GenPept UniProtKB/Swiss-Prot:P98077

    Gene LinkOut

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