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    USP19 ubiquitin specific peptidase 19 [ Homo sapiens (human) ]

    Gene ID: 10869, updated on 9-Dec-2024

    Summary

    Official Symbol
    USP19provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 19provided by HGNC
    Primary source
    HGNC:HGNC:12617
    See related
    Ensembl:ENSG00000172046 MIM:614471; AllianceGenome:HGNC:12617
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZMYND9
    Summary
    Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
    Expression
    Ubiquitous expression in testis (RPKM 12.9), thyroid (RPKM 11.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See USP19 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (49108050..49120823, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (49136122..49148895, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49145483..49158256, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene glutamine rich 1 Neighboring gene RNA, 7SL, cytoplasmic 182, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49130628-49131140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19852 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49137787-49138287 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:49140762-49141412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19854 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:49142715-49143364 Neighboring gene glutaminyl-tRNA synthetase 1 Neighboring gene microRNA 6890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:49157555-49158544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:49158545-49159533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49165495-49166412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:49168941-49169756 Neighboring gene uncharacterized LOC124909377 Neighboring gene laminin subunit beta 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49170574-49171389 Neighboring gene CRISPRi-validated cis-regulatory element chr3.2093 Neighboring gene Sharpr-MPRA regulatory region 3170 Neighboring gene laminin subunit beta 2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cysteine-type deubiquitinase activity TAS
    Traceable Author Statement
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ERAD pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of skeletal muscle tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell cycle process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein stability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to endoplasmic reticulum stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 19
    Names
    deubiquitinating enzyme 19
    ubiquitin specific protease 19
    ubiquitin thioesterase 19
    ubiquitin thiolesterase 19
    ubiquitin-specific-processing protease 19
    zinc finger MYND domain-containing protein 9
    NP_001186089.1
    NP_001186090.1
    NP_001186091.1
    NP_001338027.1
    NP_001338028.1
    NP_001338029.1
    NP_001338030.1
    NP_001338031.1
    NP_001338032.1
    NP_001338033.1
    NP_001338034.1
    NP_001338035.1
    NP_001338036.1
    NP_001338037.1
    NP_001376523.1
    NP_001376524.1
    NP_001376525.1
    NP_001376526.1
    NP_001376527.1
    NP_001376528.1
    NP_001376529.1
    NP_001376530.1
    NP_001376531.1
    NP_001376532.1
    NP_001376533.1
    NP_001376534.1
    NP_001376535.1
    NP_001376536.1
    NP_001376537.1
    NP_001387217.1
    NP_001387219.1
    NP_001387221.1
    NP_001387222.1
    NP_001387223.1
    NP_001387224.1
    NP_001387225.1
    NP_001387226.1
    NP_001387227.1
    NP_001387228.1
    NP_006668.1
    XP_005264880.1
    XP_005264881.1
    XP_005264884.1
    XP_006713009.1
    XP_006713010.1
    XP_016861116.1
    XP_047303297.1
    XP_047303298.1
    XP_047303299.1
    XP_047303300.1
    XP_047303301.1
    XP_047303302.1
    XP_047303303.1
    XP_047303304.1
    XP_047303305.1
    XP_047303306.1
    XP_047303307.1
    XP_047303308.1
    XP_047303309.1
    XP_054201008.1
    XP_054201009.1
    XP_054201010.1
    XP_054201011.1
    XP_054201012.1
    XP_054201013.1
    XP_054201014.1
    XP_054201015.1
    XP_054201016.1
    XP_054201017.1
    XP_054201018.1
    XP_054201019.1
    XP_054201020.1
    XP_054201021.1
    XP_054201022.1
    XP_054201023.1
    XP_054201024.1
    XP_054201025.1
    XP_054201026.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_054716.1 RefSeqGene

      Range
      5116..17889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001199160.2NP_001186089.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK294756, BC146752, DC323791, DC332671
      Consensus CDS
      CCDS56254.1
      UniProtKB/TrEMBL
      A0A8V8TN96
      Related
      ENSP00000401197.2, ENST00000434032.6
      Conserved Domains (7) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:389485
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:11561313
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:599785
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:892934
      zf-MYND; MYND finger
      pfam14533
      Location:799858
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:476596
      USP19_linker; Linker region of USP19 deubiquitinase
    2. NM_001199161.2NP_001186090.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the CDS and an alternate 3' exon, as compared to variant 1. The resulting isoform (2) has an internal additional 2 aa and a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      BC014934, BC048269, BC142660, DC323791, DC332671
      Consensus CDS
      CCDS56255.1
      UniProtKB/TrEMBL
      A5PL36
      Related
      ENSP00000395260.1, ENST00000417901.6
      Conserved Domains (7) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:389485
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:11581315
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:601787
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:894936
      zf-MYND; MYND finger
      pfam14533
      Location:801860
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:476598
      USP19_linker; Linker region of USP19 deubiquitinase
    3. NM_001199162.2NP_001186091.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate splice site in the CDS and an alternate 3' exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment and has a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK300425, BC014934, BC048269, DC323791, DC332671
      Consensus CDS
      CCDS56256.1
      UniProtKB/TrEMBL
      A5PL36
      Related
      ENSP00000400090.1, ENST00000453664.5
      Conserved Domains (6) summary
      cd06466
      Location:379475
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:11461303
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:589775
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:882924
      zf-MYND; MYND finger
      pfam14533
      Location:789848
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:466586
      USP19_linker; Linker region of USP19 deubiquitinase
    4. NM_001351098.2NP_001338027.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
      Conserved Domains (4) summary
      cd06463
      Location:105187
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:376472
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      pfam16602
      Location:463585
      USP19_linker; Linker region of USP19 deubiquitinase
      cl02553
      Location:5831305
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    5. NM_001351099.2NP_001338028.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:388484
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      pfam16602
      Location:475595
      USP19_linker; Linker region of USP19 deubiquitinase
      cl02553
      Location:5931315
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    6. NM_001351100.2NP_001338029.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A0A8V8TN96
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:388484
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      pfam16602
      Location:475597
      USP19_linker; Linker region of USP19 deubiquitinase
      cl02553
      Location:5951317
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    7. NM_001351101.2NP_001338030.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:391487
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      pfam16602
      Location:478598
      USP19_linker; Linker region of USP19 deubiquitinase
      cl02553
      Location:5961318
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    8. NM_001351102.2NP_001338031.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC135506
      Consensus CDS
      CCDS93271.1
      UniProtKB/TrEMBL
      E7ESU0
      Related
      ENSP00000381870.3, ENST00000398896.6
      Conserved Domains (4) summary
      cd06463
      Location:105187
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:273369
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      pfam16602
      Location:360482
      USP19_linker; Linker region of USP19 deubiquitinase
      cl02553
      Location:4801202
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    9. NM_001351103.2NP_001338032.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A0A590UK03
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:290386
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      pfam16602
      Location:377497
      USP19_linker; Linker region of USP19 deubiquitinase
      cl02553
      Location:4951217
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    10. NM_001351104.2NP_001338033.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A0A590UK03
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:290386
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      pfam16602
      Location:377499
      USP19_linker; Linker region of USP19 deubiquitinase
      cl02553
      Location:4971219
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    11. NM_001351105.2NP_001338034.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC135506
      Consensus CDS
      CCDS93274.1
      UniProtKB/TrEMBL
      A0A8I5KT08, A0A8V8TN96
      Related
      ENSP00000510256.1, ENST00000689715.1
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:339435
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      pfam16602
      Location:426546
      USP19_linker; Linker region of USP19 deubiquitinase
      cl02553
      Location:5441266
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    12. NM_001351106.2NP_001338035.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A0A590UK03
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:288384
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      pfam16602
      Location:375497
      USP19_linker; Linker region of USP19 deubiquitinase
      cl02553
      Location:4951217
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    13. NM_001351107.2NP_001338036.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
      Conserved Domains (4) summary
      cd06463
      Location:105187
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:374470
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      pfam16602
      Location:461583
      USP19_linker; Linker region of USP19 deubiquitinase
      cl02553
      Location:5811303
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    14. NM_001351108.2NP_001338037.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC135506
      Consensus CDS
      CCDS93270.1
      UniProtKB/TrEMBL
      A0A8I5KV50, E7ESU0
      Related
      ENSP00000508481.1, ENST00000691288.1
      Conserved Domains (4) summary
      cd06463
      Location:105187
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:275371
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      pfam16602
      Location:362484
      USP19_linker; Linker region of USP19 deubiquitinase
      cl02553
      Location:4821204
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    15. NM_001389594.1NP_001376523.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC135506
      Consensus CDS
      CCDS93273.1
      UniProtKB/TrEMBL
      A0A8I5KXK1, A0A8V8TN96
      Related
      ENSP00000508993.1, ENST00000692912.1
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:389485
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5961318
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:476598
      USP19_linker; Linker region of USP19 deubiquitinase
    16. NM_001389595.1NP_001376524.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A0A8V8TN96
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:391487
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5961318
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:478598
      USP19_linker; Linker region of USP19 deubiquitinase
    17. NM_001389596.1NP_001376525.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:391487
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5981320
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:478600
      USP19_linker; Linker region of USP19 deubiquitinase
    18. NM_001389597.1NP_001376526.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A0A8V8TN96
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:290386
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:4971219
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:377499
      USP19_linker; Linker region of USP19 deubiquitinase
    19. NM_001389598.1NP_001376527.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:389485
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5941316
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:476596
      USP19_linker; Linker region of USP19 deubiquitinase
    20. NM_001389599.1NP_001376528.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
      Conserved Domains (4) summary
      cd06463
      Location:105187
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:373469
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5801302
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:460582
      USP19_linker; Linker region of USP19 deubiquitinase
    21. NM_001389600.1NP_001376529.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
      Conserved Domains (4) summary
      cd06463
      Location:105187
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:374470
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5791301
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:461581
      USP19_linker; Linker region of USP19 deubiquitinase
    22. NM_001389601.1NP_001376530.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A0A8V8TN96
      Conserved Domains (4) summary
      cd06463
      Location:105187
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:374470
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5791301
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:461581
      USP19_linker; Linker region of USP19 deubiquitinase
    23. NM_001389602.1NP_001376531.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A0A8V8TN96
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:388484
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5931315
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:475595
      USP19_linker; Linker region of USP19 deubiquitinase
    24. NM_001389603.1NP_001376532.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC135506
      Consensus CDS
      CCDS93272.1
      UniProtKB/TrEMBL
      A0A0A0MR08, A0A8V8TN96
      Related
      ENSP00000303503.6, ENST00000306026.6
      Conserved Domains (4) summary
      cd06463
      Location:105187
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:374470
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5811303
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:461583
      USP19_linker; Linker region of USP19 deubiquitinase
    25. NM_001389604.1NP_001376533.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:388484
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5951317
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:475597
      USP19_linker; Linker region of USP19 deubiquitinase
    26. NM_001389605.1NP_001376534.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:339435
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5441266
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:426546
      USP19_linker; Linker region of USP19 deubiquitinase
    27. NM_001389606.1NP_001376535.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A0A8V8TN96
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:288384
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:4951217
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:375497
      USP19_linker; Linker region of USP19 deubiquitinase
    28. NM_001389607.1NP_001376536.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A0A8V8TN96
      Conserved Domains (4) summary
      cd06463
      Location:105187
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:273369
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:4801202
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:360482
      USP19_linker; Linker region of USP19 deubiquitinase
    29. NM_001389608.1NP_001376537.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A0A590UK03
      Related
      ENSP00000509474.1, ENST00000693111.1
      Conserved Domains (4) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:288384
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:4931215
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:375495
      USP19_linker; Linker region of USP19 deubiquitinase
    30. NM_001400288.1NP_001387217.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC135506
      Consensus CDS
      CCDS93273.1
      UniProtKB/TrEMBL
      A0A8I5KXK1, A0A8V8TN96
    31. NM_001400290.1NP_001387219.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
    32. NM_001400292.1NP_001387221.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC135506
      Consensus CDS
      CCDS56255.1
      UniProtKB/TrEMBL
      A5PL36
    33. NM_001400293.1NP_001387222.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
    34. NM_001400294.1NP_001387223.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
    35. NM_001400295.1NP_001387224.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
    36. NM_001400296.1NP_001387225.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
    37. NM_001400297.1NP_001387226.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
    38. NM_001400298.1NP_001387227.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 34

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
    39. NM_001400299.1NP_001387228.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC135506
      UniProtKB/TrEMBL
      A5PL36
    40. NM_006677.3NP_006668.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 4

      See identical proteins and their annotated locations for NP_006668.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (4) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      BC146752, DC323791, DC332671
      Consensus CDS
      CCDS43090.1
      UniProtKB/Swiss-Prot
      A5PKX8, A6H8U2, B4DGT3, B4DTZ0, E7EN22, E7ETS0, E9PEG8, O94966, Q3KQW4, Q641Q9, Q6NZY8, Q86XV9
      UniProtKB/TrEMBL
      A0A8V8TN96
      Related
      ENSP00000381863.2, ENST00000398888.6
      Conserved Domains (7) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:288384
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:10551212
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:498684
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:791833
      zf-MYND; MYND finger
      pfam14533
      Location:698757
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:375495
      USP19_linker; Linker region of USP19 deubiquitinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      49108050..49120823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447353.1XP_047303309.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X18

      UniProtKB/TrEMBL
      E7ESU0
    2. XM_047447352.1XP_047303308.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X17

      UniProtKB/TrEMBL
      E7ESU0
    3. XM_047447347.1XP_047303303.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X11

      UniProtKB/TrEMBL
      A5PL36
    4. XM_047447349.1XP_047303305.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X13

      UniProtKB/TrEMBL
      A5PL36
    5. XM_047447346.1XP_047303302.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X10

      UniProtKB/TrEMBL
      A5PL36
    6. XM_047447351.1XP_047303307.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X16

      UniProtKB/TrEMBL
      A0A8V8TN96
    7. XM_047447350.1XP_047303306.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X15

      UniProtKB/TrEMBL
      A0A8V8TN96
    8. XM_017005627.2XP_016861116.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X14

      UniProtKB/TrEMBL
      A0A8V8TN96
    9. XM_047447345.1XP_047303301.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TN96
    10. XM_006712947.3XP_006713010.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X7

      UniProtKB/TrEMBL
      A0A8V8TN96
      Conserved Domains (7) summary
      cd06463
      Location:105187
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:373469
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:11421299
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:585771
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:878920
      zf-MYND; MYND finger
      pfam14533
      Location:785844
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:460582
      USP19_linker; Linker region of USP19 deubiquitinase
    11. XM_047447344.1XP_047303300.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X8

      UniProtKB/TrEMBL
      A0A8V8TN96
    12. XM_047447342.1XP_047303298.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X5

      UniProtKB/TrEMBL
      A0A8V8TN96
    13. XM_047447343.1XP_047303299.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X6

      UniProtKB/TrEMBL
      A0A8V8TN96
    14. XM_005264827.3XP_005264884.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X4

      UniProtKB/TrEMBL
      A0A8V8TN96
      Conserved Domains (7) summary
      cd06463
      Location:105187
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:376472
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:11451302
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:588774
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:881923
      zf-MYND; MYND finger
      pfam14533
      Location:788847
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:463585
      USP19_linker; Linker region of USP19 deubiquitinase
    15. XM_047447348.1XP_047303304.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X12

      UniProtKB/TrEMBL
      A0A8V8TN96
    16. XM_047447341.1XP_047303297.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X3

      UniProtKB/TrEMBL
      A0A8V8TN96
    17. XM_006712946.4XP_006713009.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TN96
      Conserved Domains (7) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:390486
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:11591316
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:602788
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:895937
      zf-MYND; MYND finger
      pfam14533
      Location:802861
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:477599
      USP19_linker; Linker region of USP19 deubiquitinase
    18. XM_005264823.4XP_005264880.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X1

      See identical proteins and their annotated locations for XP_005264880.1

      UniProtKB/TrEMBL
      A0A8V8TN96
      Conserved Domains (7) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:391487
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:11601317
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:603789
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:896938
      zf-MYND; MYND finger
      pfam14533
      Location:803862
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:478600
      USP19_linker; Linker region of USP19 deubiquitinase
    19. XM_005264824.3XP_005264881.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X1

      See identical proteins and their annotated locations for XP_005264881.1

      UniProtKB/TrEMBL
      A0A8V8TN96
      Conserved Domains (7) summary
      cd06463
      Location:120202
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:391487
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:11601317
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:603789
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:896938
      zf-MYND; MYND finger
      pfam14533
      Location:803862
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:478600
      USP19_linker; Linker region of USP19 deubiquitinase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      49136122..49148895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345051.1XP_054201026.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X18

      UniProtKB/TrEMBL
      E7ESU0
    2. XM_054345050.1XP_054201025.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X17

      UniProtKB/TrEMBL
      E7ESU0
    3. XM_054345044.1XP_054201019.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X11

      UniProtKB/TrEMBL
      A5PL36
    4. XM_054345046.1XP_054201021.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X13

      UniProtKB/TrEMBL
      A5PL36
    5. XM_054345043.1XP_054201018.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X10

      UniProtKB/TrEMBL
      A5PL36
    6. XM_054345049.1XP_054201024.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X16

      UniProtKB/TrEMBL
      A0A8V8TN96
    7. XM_054345048.1XP_054201023.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X15

      UniProtKB/TrEMBL
      A0A8V8TN96
    8. XM_054345047.1XP_054201022.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X14

      UniProtKB/TrEMBL
      A0A8V8TN96
    9. XM_054345042.1XP_054201017.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TN96
    10. XM_054345040.1XP_054201015.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X7

      UniProtKB/TrEMBL
      A0A8V8TN96
    11. XM_054345041.1XP_054201016.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X8

      UniProtKB/TrEMBL
      A0A8V8TN96
    12. XM_054345038.1XP_054201013.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X5

      UniProtKB/TrEMBL
      A0A8V8TN96
    13. XM_054345039.1XP_054201014.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X6

      UniProtKB/TrEMBL
      A0A8V8TN96
    14. XM_054345037.1XP_054201012.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X4

      UniProtKB/TrEMBL
      A0A8V8TN96
    15. XM_054345045.1XP_054201020.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X12

      UniProtKB/TrEMBL
      A0A8V8TN96
    16. XM_054345036.1XP_054201011.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X3

      UniProtKB/TrEMBL
      A0A8V8TN96
    17. XM_054345035.1XP_054201010.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TN96
    18. XM_054345033.1XP_054201008.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X1

      UniProtKB/TrEMBL
      A0A8V8TN96
    19. XM_054345034.1XP_054201009.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X1

      UniProtKB/TrEMBL
      A0A8V8TN96