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    CSNK1G3 casein kinase 1 gamma 3 [ Homo sapiens (human) ]

    Gene ID: 1456, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CSNK1G3provided by HGNC
    Official Full Name
    casein kinase 1 gamma 3provided by HGNC
    Primary source
    HGNC:HGNC:2456
    See related
    Ensembl:ENSG00000151292 MIM:604253; AllianceGenome:HGNC:2456
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSNK1G3L; CKI-gamma 3
    Summary
    This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
    Expression
    Ubiquitous expression in colon (RPKM 8.2), small intestine (RPKM 7.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CSNK1G3 in Genome Data Viewer
    Location:
    5q23.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (123512177..123617049)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (124028409..124133283)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (122847871..122952743)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:122758363-122759308 Neighboring gene centrosomal protein 120 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16274 Neighboring gene keratin 8 pseudogene 33 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23005 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:122861667-122861854 Neighboring gene high mobility group box 3 pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:122964549-122965050 Neighboring gene keratin 18 pseudogene 16 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:123210028-123210778 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:123210779-123211528 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:123211529-123212279 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:123360854-123361427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23008 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:123423241-123423991 Neighboring gene long intergenic non-protein coding RNA 1170 Neighboring gene uncharacterized LOC101927397

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Intratumoral heterogeneity of CSNK1G3 mutations, a casein kinase 1, in colon cancers. Son HJ, et al. Pathol Res Pract, 2020 May. PMID 32241596
    2. A novel consensus phosphorylation motif in sulfatide- and cholesterol-3-sulfate-binding protein substrates for CK1 in vitro. Kawakami F, et al. Biol Pharm Bull, 2008 Feb. PMID 18239272
    3. Cloning and chromosome mapping of the human casein kinase I gamma3 gene (CSNK1G3). Kusuda J, et al. Cytogenet Cell Genet, 1998. PMID 9925945
    4. Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling. Agajanian MJ, et al. J Biol Chem, 2022 Jun. PMID 35487243, Free PMC Article
    5. The casein kinase I family in Wnt signaling. McKay RM, et al. Dev Biol, 2001 Jul 15. PMID 11437445

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel nanoplatform-based circCSNK1G3 affects CBX7 protein and promotes glioma cell growth.
      Title: A novel nanoplatform-based circCSNK1G3 affects CBX7 protein and promotes glioma cell growth.
    2. circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment.
      Title: circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment.
    3. Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1gamma3 in WNT signaling.
      Title: Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling.
    4. Intratumoral heterogeneity of CSNK1G3 mutations, a casein kinase 1, in colon cancers.
      Title: Intratumoral heterogeneity of CSNK1G3 mutations, a casein kinase 1, in colon cancers.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein casein kinase 1, gamma 3 (CSNK1G3) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase I isoform gamma-3; casein kinase I
    NP_001026982.1
    NP_001038188.1
    NP_001257501.1
    NP_001257502.1
    NP_001257503.1
    NP_001351069.1
    NP_001351070.1
    NP_001351072.1
    NP_001351073.1
    NP_001351074.1
    NP_001351075.1
    NP_001351076.1
    NP_001351077.1
    NP_001351078.1
    NP_001351079.1
    NP_004375.2
    XP_005271949.1
    XP_005271952.1
    XP_016864546.1
    XP_016864548.1
    XP_016864549.1
    XP_016864551.1
    XP_016864552.1
    XP_016864553.1
    XP_016864554.1
    XP_016864556.1
    XP_016864557.1
    XP_016864558.1
    XP_016864559.1
    XP_047272698.1
    XP_047272699.1
    XP_047272700.1
    XP_047272701.1
    XP_047272702.1
    XP_047272703.1
    XP_047272704.1
    XP_047272705.1
    XP_047272706.1
    XP_047272707.1
    XP_047272708.1
    XP_047272710.1
    XP_047272711.1
    XP_047272712.1
    XP_047272713.1
    XP_047272714.1
    XP_047272715.1
    XP_047272716.1
    XP_047272717.1
    XP_047272719.1
    XP_047272720.1
    XP_047272721.1
    XP_047272722.1
    XP_047272723.1
    XP_047272724.1
    XP_047272725.1
    XP_047272726.1
    XP_047272727.1
    XP_047272728.1
    XP_047272729.1
    XP_047272730.1
    XP_047272731.1
    XP_054207639.1
    XP_054207640.1
    XP_054207641.1
    XP_054207642.1
    XP_054207643.1
    XP_054207644.1
    XP_054207645.1
    XP_054207646.1
    XP_054207647.1
    XP_054207648.1
    XP_054207649.1
    XP_054207650.1
    XP_054207651.1
    XP_054207652.1
    XP_054207653.1
    XP_054207654.1
    XP_054207655.1
    XP_054207656.1
    XP_054207657.1
    XP_054207658.1
    XP_054207659.1
    XP_054207660.1
    XP_054207661.1
    XP_054207662.1
    XP_054207663.1
    XP_054207664.1
    XP_054207665.1
    XP_054207666.1
    XP_054207667.1
    XP_054207668.1
    XP_054207669.1
    XP_054207670.1
    XP_054207671.1
    XP_054207672.1
    XP_054207673.1
    XP_054207674.1
    XP_054207675.1
    XP_054207676.1
    XP_054207677.1
    XP_054207678.1
    XP_054207679.1
    XP_054207680.1
    XP_054207681.1
    XP_054207682.1
    XP_054207683.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031812.4 → NP_001026982.1  casein kinase I isoform gamma-3 isoform 2

      See identical proteins and their annotated locations for NP_001026982.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC008541, AF049089, BC047567, BX116822, DA409424
      Consensus CDS
      CCDS34218.1
      UniProtKB/Swiss-Prot
      Q9Y6M4
      Related
      ENSP00000429412.1, ENST00000521364.5
      Conserved Domains (2) summary
      cd14126
      Location:42 → 328
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:328 → 385
      CK1gamma_C; Casein kinase 1 gamma C terminal

    2. NM_001044723.2 → NP_001038188.1  casein kinase I isoform gamma-3 isoform 4

      See identical proteins and their annotated locations for NP_001038188.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as CSNK1G3L) contains an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
      Source sequence(s)
      AC008541, AF049090, BC047567, BX116822
      Consensus CDS
      CCDS43355.1
      UniProtKB/Swiss-Prot
      Q9Y6M4
      Related
      ENSP00000353904.2, ENST00000360683.6
      Conserved Domains (2) summary
      cd14126
      Location:42 → 328
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:328 → 417
      CK1gamma_C; Casein kinase 1 gamma C terminal

    3. NM_001270572.1 → NP_001257501.1  casein kinase I isoform gamma-3 isoform 5

      See identical proteins and their annotated locations for NP_001257501.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC008541, AK289405, BC047567, BX116822
      Consensus CDS
      CCDS59491.1
      UniProtKB/Swiss-Prot
      Q9Y6M4
      Related
      ENSP00000423838.2, ENST00000510842.6
      Conserved Domains (2) summary
      cd14126
      Location:42 → 329
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:329 → 386
      CK1gamma_C; Casein kinase 1 gamma C terminal

    4. NM_001270573.2 → NP_001257502.1  casein kinase I isoform gamma-3 isoform 6

      See identical proteins and their annotated locations for NP_001257502.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and has multiple differences in the coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (6) has a shorter N-terminus, compared to isoform 1. Variants 6, 16, and 17 all encode the same isoform (6).
      Source sequence(s)
      AC008541, AK299739, BX116822, DA409424
      Consensus CDS
      CCDS59492.1
      UniProtKB/Swiss-Prot
      Q9Y6M4
      Related
      ENSP00000421998.3, ENST00000512718.7
      Conserved Domains (2) summary
      pfam12605
      Location:253 → 310
      CK1gamma_C; Casein kinase 1 gamma C terminal
      cl21453
      Location:1 → 253
      PKc_like; Protein Kinases, catalytic domain

    5. NM_001270574.2 → NP_001257503.1  casein kinase I isoform gamma-3 isoform 7

      See identical proteins and their annotated locations for NP_001257503.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and has multiple differences in the coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (7) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC008541, AK316019, BX116822, DA409424
      Consensus CDS
      CCDS59493.1
      UniProtKB/Swiss-Prot
      Q9Y6M4
      Related
      ENSP00000421385.2, ENST00000511130.6
      Conserved Domains (2) summary
      pfam12605
      Location:216 → 273
      CK1gamma_C; Casein kinase 1 gamma C terminal
      cl21453
      Location:1 → 216
      PKc_like; Protein Kinases, catalytic domain

    6. NM_001364140.2 → NP_001351069.1  casein kinase I isoform gamma-3 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (8) is 1 aa longer compared to isoform 1 and is the longest isoform.
      Source sequence(s)
      AC008541, AC026422
      Consensus CDS
      CCDS93772.1
      UniProtKB/TrEMBL
      A0A8V8TKT3
      Related
      ENSP00000512966.1, ENST00000696905.1
      Conserved Domains (2) summary
      cd14126
      Location:42 → 329
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:329 → 418
      CK1gamma_C; Casein kinase 1 gamma C terminal

    7. NM_001364141.2 → NP_001351070.1  casein kinase I isoform gamma-3 isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) contains an alternate in-frame exon and lacks another alternate in-frame exon compared to variant 1. The resulting isoform (9) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC008541, AC026422
      Conserved Domains (2) summary
      cd14126
      Location:42 → 353
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:353 → 399
      CK1gamma_C; Casein kinase 1 gamma C terminal

    8. NM_001364143.2 → NP_001351072.1  casein kinase I isoform gamma-3 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternate in-frame splice junction and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (10) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC008541, AC026422
      Conserved Domains (2) summary
      cd14126
      Location:42 → 329
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:329 → 386
      CK1gamma_C; Casein kinase 1 gamma C terminal

    9. NM_001364144.2 → NP_001351073.1  casein kinase I isoform gamma-3 isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (11) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC008541, AC026422
      Conserved Domains (2) summary
      pfam12605
      Location:253 → 342
      CK1gamma_C; Casein kinase 1 gamma C terminal
      cl21453
      Location:1 → 253
      PKc_like; Protein Kinases, catalytic domain

    10. NM_001364145.2 → NP_001351074.1  casein kinase I isoform gamma-3 isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR and coding sequence, uses an alternate in-frame splice junction, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (12) is shorter at the N-terminus and lacks two alternate internal segments compared to isoform 1.
      Source sequence(s)
      AC008541, AC026422
      Conserved Domains (2) summary
      pfam12605
      Location:254 → 311
      CK1gamma_C; Casein kinase 1 gamma C terminal
      cl21453
      Location:1 → 254
      PKc_like; Protein Kinases, catalytic domain

    11. NM_001364146.2 → NP_001351075.1  casein kinase I isoform gamma-3 isoform 13

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (13) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC008541, AC026422
      Conserved Domains (2) summary
      pfam12605
      Location:215 → 304
      CK1gamma_C; Casein kinase 1 gamma C terminal
      cl21453
      Location:1 → 215
      PKc_like; Protein Kinases, catalytic domain

    12. NM_001364147.2 → NP_001351076.1  casein kinase I isoform gamma-3 isoform 14

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (14) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC008541, AC026422
      Conserved Domains (2) summary
      pfam12605
      Location:215 → 272
      CK1gamma_C; Casein kinase 1 gamma C terminal
      cl21453
      Location:1 → 215
      PKc_like; Protein Kinases, catalytic domain

    13. NM_001364148.2 → NP_001351077.1  casein kinase I isoform gamma-3 isoform 15

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) differs in the 5' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (15) is shorter at the N-terminus and lacks two alternate internal segments compared to isoform 1.
      Source sequence(s)
      AC008541, AC026422
      Conserved Domains (2) summary
      pfam12605
      Location:215 → 272
      CK1gamma_C; Casein kinase 1 gamma C terminal
      cl21453
      Location:1 → 215
      PKc_like; Protein Kinases, catalytic domain

    14. NM_001364149.2 → NP_001351078.1  casein kinase I isoform gamma-3 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1. Variants 6, 16, and 17 all encode the same isoform (6).
      Source sequence(s)
      AC008541, AC026422
      Consensus CDS
      CCDS59492.1
      Conserved Domains (2) summary
      pfam12605
      Location:253 → 310
      CK1gamma_C; Casein kinase 1 gamma C terminal
      cl21453
      Location:1 → 253
      PKc_like; Protein Kinases, catalytic domain

    15. NM_001364150.2 → NP_001351079.1  casein kinase I isoform gamma-3 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1. Variants 6, 16, and 17 all encode the same isoform (6).
      Source sequence(s)
      AC008541, AC026422
      Consensus CDS
      CCDS59492.1
      Conserved Domains (2) summary
      pfam12605
      Location:253 → 310
      CK1gamma_C; Casein kinase 1 gamma C terminal
      cl21453
      Location:1 → 253
      PKc_like; Protein Kinases, catalytic domain

    16. NM_004384.5 → NP_004375.2  casein kinase I isoform gamma-3 isoform 1

      See identical proteins and their annotated locations for NP_004375.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC008541, AC026422
      Consensus CDS
      CCDS4135.1
      UniProtKB/Swiss-Prot
      A8K040, B4DSH2, B7Z9Q4, E7EVD0, Q86WZ7, Q9Y6M3, Q9Y6M4
      Related
      ENSP00000354942.2, ENST00000361991.6
      Conserved Domains (2) summary
      cd14126
      Location:42 → 328
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:328 → 417
      CK1gamma_C; Casein kinase 1 gamma C terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      123512177..123617049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009060.2 → XP_016864549.1  casein kinase I isoform X1

    2. XM_047416765.1 → XP_047272721.1  casein kinase I isoform X19

    3. XM_047416768.1 → XP_047272724.1  casein kinase I isoform X20

    4. XM_017009059.2 → XP_016864548.1  casein kinase I isoform X1

    5. XM_047416755.1 → XP_047272711.1  casein kinase I isoform X11

    6. XM_047416763.1 → XP_047272719.1  casein kinase I isoform X17

    7. XM_047416764.1 → XP_047272720.1  casein kinase I isoform X18

    8. XM_047416757.1 → XP_047272713.1  casein kinase I isoform X12

    9. XM_017009069.2 → XP_016864558.1  casein kinase I isoform X19

      UniProtKB/Swiss-Prot
      Q9Y6M4
      Conserved Domains (2) summary
      cd14126
      Location:42 → 329
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:329 → 386
      CK1gamma_C; Casein kinase 1 gamma C terminal

    10. XM_047416770.1 → XP_047272726.1  casein kinase I isoform X21

    11. XM_047416749.1 → XP_047272705.1  casein kinase I isoform X8

    12. XM_047416758.1 → XP_047272714.1  casein kinase I isoform X14

      UniProtKB/Swiss-Prot
      A8K040, B4DSH2, B7Z9Q4, E7EVD0, Q86WZ7, Q9Y6M3, Q9Y6M4

    13. XM_047416754.1 → XP_047272710.1  casein kinase I isoform X10

    14. XM_047416766.1 → XP_047272722.1  casein kinase I isoform X20

    15. XM_047416773.1 → XP_047272729.1  casein kinase I isoform X22

    16. XM_017009057.3 → XP_016864546.1  casein kinase I isoform X1

    17. XM_017009063.3 → XP_016864552.1  casein kinase I isoform X4

    18. XM_047416745.1 → XP_047272701.1  casein kinase I isoform X3

    19. XM_047416747.1 → XP_047272703.1  casein kinase I isoform X6

    20. XM_017009064.3 → XP_016864553.1  casein kinase I isoform X11

    21. XM_017009067.3 → XP_016864556.1  casein kinase I isoform X17

    22. XM_047416746.1 → XP_047272702.1  casein kinase I isoform X5

    23. XM_017009065.3 → XP_016864554.1  casein kinase I isoform X13

      Conserved Domains (2) summary
      cd14126
      Location:42 → 353
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:353 → 399
      CK1gamma_C; Casein kinase 1 gamma C terminal

    24. XM_017009068.3 → XP_016864557.1  casein kinase I isoform X18

    25. XM_047416756.1 → XP_047272712.1  casein kinase I isoform X12

    26. XM_047416751.1 → XP_047272707.1  casein kinase I isoform X9

    27. XM_047416759.1 → XP_047272715.1  casein kinase I isoform X15

    28. XM_005271895.4 → XP_005271952.1  casein kinase I isoform X19

      See identical proteins and their annotated locations for XP_005271952.1

      UniProtKB/Swiss-Prot
      Q9Y6M4
      Conserved Domains (2) summary
      cd14126
      Location:42 → 329
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:329 → 386
      CK1gamma_C; Casein kinase 1 gamma C terminal

    29. XM_005271892.4 → XP_005271949.1  casein kinase I isoform X8

      See identical proteins and their annotated locations for XP_005271949.1

      UniProtKB/Swiss-Prot
      Q9Y6M4
      Related
      ENSP00000334735.5, ENST00000345990.9
      Conserved Domains (2) summary
      cd14126
      Location:42 → 328
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:328 → 417
      CK1gamma_C; Casein kinase 1 gamma C terminal

    30. XM_047416752.1 → XP_047272708.1  casein kinase I isoform X10

    31. XM_047416761.1 → XP_047272717.1  casein kinase I isoform X16

    32. XM_017009070.3 → XP_016864559.1  casein kinase I isoform X22

      Conserved Domains (2) summary
      cd14126
      Location:42 → 328
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:328 → 385
      CK1gamma_C; Casein kinase 1 gamma C terminal

    33. XM_047416743.1 → XP_047272699.1  casein kinase I isoform X1

    34. XM_047416767.1 → XP_047272723.1  casein kinase I isoform X20

    35. XM_047416760.1 → XP_047272716.1  casein kinase I isoform X15

    36. XM_047416771.1 → XP_047272727.1  casein kinase I isoform X21

    37. XM_047416774.1 → XP_047272730.1  casein kinase I isoform X22

    38. XM_047416742.1 → XP_047272698.1  casein kinase I isoform X1

    39. XM_047416744.1 → XP_047272700.1  casein kinase I isoform X1

    40. XM_017009062.2 → XP_016864551.1  casein kinase I isoform X2

    41. XM_047416748.1 → XP_047272704.1  casein kinase I isoform X7

      UniProtKB/TrEMBL
      A0A8V8TKT3

    42. XM_047416750.1 → XP_047272706.1  casein kinase I isoform X8

    43. XM_047416772.1 → XP_047272728.1  casein kinase I isoform X21

    44. XM_047416769.1 → XP_047272725.1  casein kinase I isoform X20

    45. XM_047416775.1 → XP_047272731.1  casein kinase I isoform X22

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      124028409..124133283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351668.1 → XP_054207643.1  casein kinase I isoform X1

    2. XM_054351697.1 → XP_054207672.1  casein kinase I isoform X19

    3. XM_054351700.1 → XP_054207675.1  casein kinase I isoform X20

    4. XM_054351666.1 → XP_054207641.1  casein kinase I isoform X1

    5. XM_054351683.1 → XP_054207658.1  casein kinase I isoform X11

    6. XM_054351692.1 → XP_054207667.1  casein kinase I isoform X17

    7. XM_054351694.1 → XP_054207669.1  casein kinase I isoform X18

    8. XM_054351685.1 → XP_054207660.1  casein kinase I isoform X12

    9. XM_054351696.1 → XP_054207671.1  casein kinase I isoform X19

    10. XM_054351702.1 → XP_054207677.1  casein kinase I isoform X21

    11. XM_054351677.1 → XP_054207652.1  casein kinase I isoform X8

    12. XM_054351687.1 → XP_054207662.1  casein kinase I isoform X14

      UniProtKB/Swiss-Prot
      A8K040, B4DSH2, B7Z9Q4, E7EVD0, Q86WZ7, Q9Y6M3, Q9Y6M4

    13. XM_054351681.1 → XP_054207656.1  casein kinase I isoform X10

    14. XM_054351698.1 → XP_054207673.1  casein kinase I isoform X20

    15. XM_054351706.1 → XP_054207681.1  casein kinase I isoform X22

    16. XM_054351664.1 → XP_054207639.1  casein kinase I isoform X1

    17. XM_054351672.1 → XP_054207647.1  casein kinase I isoform X4

    18. XM_054351671.1 → XP_054207646.1  casein kinase I isoform X3

    19. XM_054351674.1 → XP_054207649.1  casein kinase I isoform X6

    20. XM_054351682.1 → XP_054207657.1  casein kinase I isoform X11

    21. XM_054351691.1 → XP_054207666.1  casein kinase I isoform X17

    22. XM_054351673.1 → XP_054207648.1  casein kinase I isoform X5

    23. XM_054351686.1 → XP_054207661.1  casein kinase I isoform X13

    24. XM_054351693.1 → XP_054207668.1  casein kinase I isoform X18

    25. XM_054351684.1 → XP_054207659.1  casein kinase I isoform X12

    26. XM_054351679.1 → XP_054207654.1  casein kinase I isoform X9

    27. XM_054351688.1 → XP_054207663.1  casein kinase I isoform X15

    28. XM_054351695.1 → XP_054207670.1  casein kinase I isoform X19

    29. XM_054351676.1 → XP_054207651.1  casein kinase I isoform X8

    30. XM_054351680.1 → XP_054207655.1  casein kinase I isoform X10

    31. XM_054351690.1 → XP_054207665.1  casein kinase I isoform X16

    32. XM_054351705.1 → XP_054207680.1  casein kinase I isoform X22

    33. XM_054351667.1 → XP_054207642.1  casein kinase I isoform X1

    34. XM_054351699.1 → XP_054207674.1  casein kinase I isoform X20

    35. XM_054351689.1 → XP_054207664.1  casein kinase I isoform X15

    36. XM_054351703.1 → XP_054207678.1  casein kinase I isoform X21

    37. XM_054351707.1 → XP_054207682.1  casein kinase I isoform X22

    38. XM_054351665.1 → XP_054207640.1  casein kinase I isoform X1

    39. XM_054351669.1 → XP_054207644.1  casein kinase I isoform X1

    40. XM_054351670.1 → XP_054207645.1  casein kinase I isoform X2

    41. XM_054351675.1 → XP_054207650.1  casein kinase I isoform X7

      UniProtKB/TrEMBL
      A0A8V8TKT3

    42. XM_054351678.1 → XP_054207653.1  casein kinase I isoform X8

    43. XM_054351704.1 → XP_054207679.1  casein kinase I isoform X21

    44. XM_054351701.1 → XP_054207676.1  casein kinase I isoform X20

    45. XM_054351708.1 → XP_054207683.1  casein kinase I isoform X22

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001044722.1: Suppressed sequence

      Description
      NM_001044722.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y6M4.2 GenPept UniProtKB/Swiss-Prot:Q9Y6M4

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