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    TMEM181 transmembrane protein 181 [ Homo sapiens (human) ]

    Gene ID: 57583, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TMEM181provided by HGNC
    Official Full Name
    transmembrane protein 181provided by HGNC
    Primary source
    HGNC:HGNC:20958
    See related
    Ensembl:ENSG00000146433 MIM:613209; AllianceGenome:HGNC:20958
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR178; KIAA1423
    Summary
    The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]
    Expression
    Ubiquitous expression in stomach (RPKM 9.9), testis (RPKM 9.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM181 in Genome Data Viewer
    Location:
    6q25.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (158536640..158635429)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (159781619..159880620)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (158957672..159056461)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TUB like protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25355 Neighboring gene RNA, 7SL, cytoplasmic 173, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:158884819-158885810 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:158885811-158886802 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:158890813-158891694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:158895792-158896364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158900383-158900884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158927517-158928017 Neighboring gene Sharpr-MPRA regulatory region 4140 Neighboring gene Sharpr-MPRA regulatory region 10808 Neighboring gene calcyclin binding protein pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 807 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17739 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158982655-158983154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158982153-158982654 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:159000120-159000332 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:159030351-159030852 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:159051575-159052076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:159052077-159052576 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:159053255-159053416 Neighboring gene TatD DNase domain containing 2 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:159065146-159066089 Neighboring gene microRNA 7161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17742 Neighboring gene dynein light chain Tctex-type 1 Neighboring gene MPRA-validated peak6273 silencer Neighboring gene synaptotagmin like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25359 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:159128779-159129410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:159129411-159130042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25360 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:159141094-159142293 Neighboring gene AMZ2 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TMEM181: a key mediator of cytolethal distending toxin required for Wnt signaling activity. Zhang J, et al. J Genet Genomics, 2023 Jan. PMID 35577237
    2. A general model of G protein-coupled receptor sequences and its application to detect remote homologs. Wistrand M, et al. Protein Sci, 2006 Mar. PMID 16452613, Free PMC Article
    3. Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. Wollscheid B, et al. Nat Biotechnol, 2009 Apr. PMID 19349973, Free PMC Article
    4. Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A. Hoel CM, et al. Elife, 2022 Nov 14. PMID 36373655, Free PMC Article
    5. Haploid genetic screens in human cells identify host factors used by pathogens. Carette JE, et al. Science, 2009 Nov 27. PMID 19965467

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of transmembrane protein 181 (TMEM181) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables toxic substance binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables toxic substance binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 181
    Names
    G protein-coupled receptor 178

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376817.1 → NP_001363746.1  transmembrane protein 181 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL591025
      UniProtKB/TrEMBL
      A0AAQ5BHG2
      Conserved Domains (1) summary
      pfam06664
      Location:177 → 472
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    2. NM_001376850.1 → NP_001363779.1  transmembrane protein 181 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL591025
      UniProtKB/TrEMBL
      A0AAQ5BHG2
      Conserved Domains (1) summary
      pfam06664
      Location:136 → 431
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    3. NM_001376852.1 → NP_001363781.1  transmembrane protein 181 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL591025
      Consensus CDS
      CCDS94026.1
      UniProtKB/Swiss-Prot
      A0A804HII6, Q5VTU1, Q9P2C4
      UniProtKB/TrEMBL
      A0AAQ5BHG2
      Related
      ENSP00000507085.1, ENST00000684151.1
      Conserved Domains (1) summary
      pfam06664
      Location:128 → 423
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    4. NM_001376854.1 → NP_001363783.1  transmembrane protein 181 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL591025
      UniProtKB/TrEMBL
      A0AAQ5BHG2
      Conserved Domains (1) summary
      pfam06664
      Location:128 → 396
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    5. NM_001376855.1 → NP_001363784.1  transmembrane protein 181 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL591025
      UniProtKB/TrEMBL
      A0AAQ5BHG2
      Conserved Domains (1) summary
      pfam06664
      Location:96 → 391
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    6. NM_001376856.1 → NP_001363785.1  transmembrane protein 181 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL591025
      UniProtKB/TrEMBL
      A0AAQ5BHG2
      Conserved Domains (1) summary
      pfam06664
      Location:47 → 342
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    7. NM_020823.2 → NP_065874.2  transmembrane protein 181 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL591025
      Consensus CDS
      CCDS43520.2
      UniProtKB/TrEMBL
      A0AAQ5BHG2
      Related
      ENSP00000356057.4, ENST00000367090.4
      Conserved Domains (1) summary
      pfam06664
      Location:170 → 464
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    RNA

    1. NR_164859.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591025
      Related
      ENST00000714114.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      158536640..158635429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536000.2 → XP_011534302.2  transmembrane protein 181 isoform X1

      UniProtKB/TrEMBL
      A0AAQ5BHQ5

    2. XM_011536003.3 → XP_011534305.2  transmembrane protein 181 isoform X5

      UniProtKB/TrEMBL
      A0AAQ5BHF0

    3. XM_047419182.1 → XP_047275138.1  transmembrane protein 181 isoform X6

      UniProtKB/TrEMBL
      A0AAQ5BHF0

    4. XM_047419183.1 → XP_047275139.1  transmembrane protein 181 isoform X7

      UniProtKB/TrEMBL
      A0AAQ5BHQ5
      Related
      ENSP00000519487.1, ENST00000714203.1

    5. XM_047419185.1 → XP_047275141.1  transmembrane protein 181 isoform X9

      UniProtKB/TrEMBL
      A0AAQ5BHF0, A0AAQ5BHM7
      Related
      ENSP00000519507.1, ENST00000714226.1

    6. XM_047419187.1 → XP_047275143.1  transmembrane protein 181 isoform X10

      UniProtKB/TrEMBL
      A0AAQ5BHF0
      Related
      ENSP00000519409.1, ENST00000714117.1

    7. XM_011536001.3 → XP_011534303.1  transmembrane protein 181 isoform X3

      UniProtKB/TrEMBL
      A0AAQ5BHG2
      Conserved Domains (1) summary
      pfam06664
      Location:154 → 449
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    8. XM_011536002.3 → XP_011534304.1  transmembrane protein 181 isoform X4

      UniProtKB/TrEMBL
      A0AAQ5BHG2
      Related
      ENSP00000519410.1, ENST00000714118.1
      Conserved Domains (1) summary
      pfam06664
      Location:146 → 441
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    9. XM_047419184.1 → XP_047275140.1  transmembrane protein 181 isoform X8

      UniProtKB/TrEMBL
      A0AAQ5BHF0

    10. XM_047419181.1 → XP_047275137.1  transmembrane protein 181 isoform X2

      UniProtKB/TrEMBL
      A0AAQ5BHG2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      159781619..159880620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356096.1 → XP_054212071.1  transmembrane protein 181 isoform X1

      UniProtKB/TrEMBL
      A0AAQ5BHQ5

    2. XM_054356100.1 → XP_054212075.1  transmembrane protein 181 isoform X5

      UniProtKB/TrEMBL
      A0AAQ5BHF0

    3. XM_054356101.1 → XP_054212076.1  transmembrane protein 181 isoform X6

      UniProtKB/TrEMBL
      A0AAQ5BHF0

    4. XM_054356102.1 → XP_054212077.1  transmembrane protein 181 isoform X7

      UniProtKB/TrEMBL
      A0AAQ5BHQ5

    5. XM_054356104.1 → XP_054212079.1  transmembrane protein 181 isoform X9

      UniProtKB/TrEMBL
      A0AAQ5BHF0, A0AAQ5BHM7

    6. XM_054356105.1 → XP_054212080.1  transmembrane protein 181 isoform X10

      UniProtKB/TrEMBL
      A0AAQ5BHF0

    7. XM_054356099.1 → XP_054212074.1  transmembrane protein 181 isoform X4

      UniProtKB/TrEMBL
      A0AAQ5BHG2

    8. XM_054356103.1 → XP_054212078.1  transmembrane protein 181 isoform X8

      UniProtKB/TrEMBL
      A0AAQ5BHF0

    9. XM_054356098.1 → XP_054212073.1  transmembrane protein 181 isoform X3

      UniProtKB/TrEMBL
      A0AAQ5BHG2

    10. XM_054356097.1 → XP_054212072.1  transmembrane protein 181 isoform X2

      UniProtKB/TrEMBL
      A0AAQ5BHG2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P2C4.3 GenPept UniProtKB/Swiss-Prot:Q9P2C4

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