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    TTC16 tetratricopeptide repeat domain 16 [ Homo sapiens (human) ]

    Gene ID: 158248, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TTC16provided by HGNC
    Official Full Name
    tetratricopeptide repeat domain 16provided by HGNC
    Primary source
    HGNC:HGNC:26536
    See related
    Ensembl:ENSG00000167094 AllianceGenome:HGNC:26536
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in testis (RPKM 9.1), lung (RPKM 0.9) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TTC16 in Genome Data Viewer
    Location:
    9q34.11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (127716079..127731590)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (139923034..139939034)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130478358..130493869)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene syntaxin binding protein 1 Neighboring gene OCT4 hESC enhancer GRCh37_chr9:130463106-130463614 Neighboring gene microRNA 3911 Neighboring gene peptidyl-tRNA hydrolase 1 homolog Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130476687-130477343 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29046 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:130478240-130478416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29047 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:130480462-130480664 Neighboring gene cilia and flagella associated protein 157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130488893-130489394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130496147-130497053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130504225-130504852 Neighboring gene torsin family 2 member A Neighboring gene SH2 domain containing 3C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130523547-130524424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130524425-130525300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130526508-130527090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20309 Neighboring gene uncharacterized LOC107987132 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:130539526-130539796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29050 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:130545551-130545741 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29052 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20310 Neighboring gene Sharpr-MPRA regulatory region 7866 Neighboring gene microRNA 3960 Neighboring gene microRNA 2861

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Isoform-specific GSK3A activity is negatively correlated with human sperm motility. Freitas MJ, et al. Mol Hum Reprod, 2019 Apr 1. PMID 30824926, Free PMC Article
    2. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article
    3. New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing. Basei FL, et al. Proteome Sci, 2015. PMID 25798074, Free PMC Article
    4. In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker. Gao H, et al. Anal Chem, 2022 May 31. PMID 35575683
    5. UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination. Liu J, et al. Nat Cell Biol, 2020 Sep. PMID 32807901

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32780

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 16
    Names
    TPR repeat protein 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317037.2 → NP_001303966.1  tetratricopeptide repeat protein 16 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK057342, AK302737
      UniProtKB/TrEMBL
      B4DZ42
      Conserved Domains (4) summary
      sd00006
      Location:320 → 346
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:355 → 385
      TPR_1; Tetratricopeptide repeat
      pfam05338
      Location:71 → 130
      DUF717; Protein of unknown function (DUF717)
      pfam13414
      Location:319 → 383
      TPR_11; TPR repeat

    2. NM_144965.3 → NP_659402.1  tetratricopeptide repeat protein 16 isoform 1

      See identical proteins and their annotated locations for NP_659402.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK057342
      Consensus CDS
      CCDS6875.1
      UniProtKB/Swiss-Prot
      B4DYG4, B5ME24, Q5JU66, Q8NEE8, Q96M72
      UniProtKB/TrEMBL
      B4DZ42
      Related
      ENSP00000362386.3, ENST00000373289.4
      Conserved Domains (3) summary
      sd00006
      Location:333 → 359
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:368 → 398
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:62 → 124
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      127716079..127731590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518283.3 → XP_011516585.1  tetratricopeptide repeat protein 16 isoform X1

      UniProtKB/TrEMBL
      B4DZ42
      Conserved Domains (3) summary
      sd00006
      Location:333 → 359
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:368 → 398
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:62 → 124
      TPR_11; TPR repeat

    2. XM_011518285.3 → XP_011516587.1  tetratricopeptide repeat protein 16 isoform X3

      UniProtKB/TrEMBL
      B4DZ42
      Conserved Domains (4) summary
      sd00006
      Location:61 → 89
      TPR; TPR repeat [structural motif]
      cd15830
      Location:61 → 149
      BamD; BamD lipoprotein, a component of the beta-barrel assembly machinery
      pfam13371
      Location:260 → 325
      TPR_9; Tetratricopeptide repeat
      pfam13414
      Location:62 → 124
      TPR_11; TPR repeat

    3. XM_047422835.1 → XP_047278791.1  tetratricopeptide repeat protein 16 isoform X4

      UniProtKB/TrEMBL
      B4DZ42

    4. XM_011518284.3 → XP_011516586.1  tetratricopeptide repeat protein 16 isoform X2

      UniProtKB/TrEMBL
      B4DZ42
      Conserved Domains (4) summary
      COG0457
      Location:70 → 348
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 311
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:320 → 350
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:319 → 389
      TPR_11; TPR repeat

    5. XM_011518288.3 → XP_011516590.1  tetratricopeptide repeat protein 16 isoform X5

      UniProtKB/TrEMBL
      B4DZ42
      Conserved Domains (3) summary
      sd00006
      Location:156 → 184
      TPR; TPR repeat [structural motif]
      pfam13371
      Location:212 → 277
      TPR_9; Tetratricopeptide repeat
      pfam13414
      Location:62 → 119
      TPR_11; TPR repeat

    6. XM_047422838.1 → XP_047278794.1  tetratricopeptide repeat protein 16 isoform X12

    7. XM_011518293.3 → XP_011516595.1  tetratricopeptide repeat protein 16 isoform X10

      Conserved Domains (3) summary
      sd00006
      Location:333 → 359
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:368 → 398
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:62 → 124
      TPR_11; TPR repeat

    8. XM_047422837.1 → XP_047278793.1  tetratricopeptide repeat protein 16 isoform X9

    9. XM_047422840.1 → XP_047278796.1  tetratricopeptide repeat protein 16 isoform X14

    10. XM_011518295.2 → XP_011516597.1  tetratricopeptide repeat protein 16 isoform X13

      Conserved Domains (3) summary
      sd00006
      Location:333 → 359
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:368 → 398
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:62 → 124
      TPR_11; TPR repeat

    11. XM_011518294.3 → XP_011516596.1  tetratricopeptide repeat protein 16 isoform X11

      Conserved Domains (3) summary
      sd00006
      Location:333 → 359
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:368 → 398
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:62 → 124
      TPR_11; TPR repeat

    12. XM_011518297.2 → XP_011516599.1  tetratricopeptide repeat protein 16 isoform X15

      Conserved Domains (3) summary
      sd00006
      Location:333 → 359
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:368 → 398
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:62 → 124
      TPR_11; TPR repeat

    13. XM_011518298.4 → XP_011516600.1  tetratricopeptide repeat protein 16 isoform X16

      Conserved Domains (3) summary
      sd00006
      Location:61 → 89
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:368 → 398
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:62 → 124
      TPR_11; TPR repeat

    14. XM_047422839.1 → XP_047278795.1  tetratricopeptide repeat protein 16 isoform X12

    15. XM_011518292.3 → XP_011516594.1  tetratricopeptide repeat protein 16 isoform X7

      See identical proteins and their annotated locations for XP_011516594.1

      Conserved Domains (2) summary
      PHA03247
      Location:40 → 292
      PHA03247; large tegument protein UL36; Provisional
      COG5099
      Location:391 → 569
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]

    16. XM_047422836.1 → XP_047278792.1  tetratricopeptide repeat protein 16 isoform X8

    17. XM_011518290.3 → XP_011516592.1  tetratricopeptide repeat protein 16 isoform X6

      See identical proteins and their annotated locations for XP_011516592.1

      Related
      ENST00000488285.1
      Conserved Domains (3) summary
      sd00006
      Location:155 → 181
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:190 → 220
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:154 → 218
      TPR_11; TPR repeat

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      139923034..139939034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362091.1 → XP_054218066.1  tetratricopeptide repeat protein 16 isoform X3

      UniProtKB/TrEMBL
      B4DZ42

    2. XM_054362090.1 → XP_054218065.1  tetratricopeptide repeat protein 16 isoform X2

      UniProtKB/TrEMBL
      B4DZ42

    3. XM_054362093.1 → XP_054218068.1  tetratricopeptide repeat protein 16 isoform X5

      UniProtKB/TrEMBL
      B4DZ42

    4. XM_054362100.1 → XP_054218075.1  tetratricopeptide repeat protein 16 isoform X12

    5. XM_054362089.1 → XP_054218064.1  tetratricopeptide repeat protein 16 isoform X1

      UniProtKB/TrEMBL
      B4DZ42

    6. XM_054362092.1 → XP_054218067.1  tetratricopeptide repeat protein 16 isoform X4

      UniProtKB/TrEMBL
      B4DZ42

    7. XM_054362098.1 → XP_054218073.1  tetratricopeptide repeat protein 16 isoform X10

    8. XM_054362097.1 → XP_054218072.1  tetratricopeptide repeat protein 16 isoform X9

    9. XM_054362103.1 → XP_054218078.1  tetratricopeptide repeat protein 16 isoform X14

    10. XM_054362102.1 → XP_054218077.1  tetratricopeptide repeat protein 16 isoform X13

    11. XM_054362099.1 → XP_054218074.1  tetratricopeptide repeat protein 16 isoform X11

    12. XM_054362104.1 → XP_054218079.1  tetratricopeptide repeat protein 16 isoform X15

    13. XM_054362105.1 → XP_054218080.1  tetratricopeptide repeat protein 16 isoform X16

    14. XM_054362101.1 → XP_054218076.1  tetratricopeptide repeat protein 16 isoform X12

    15. XM_054362095.1 → XP_054218070.1  tetratricopeptide repeat protein 16 isoform X7

    16. XM_054362096.1 → XP_054218071.1  tetratricopeptide repeat protein 16 isoform X8

    17. XM_054362094.1 → XP_054218069.1  tetratricopeptide repeat protein 16 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NEE8.2 GenPept UniProtKB/Swiss-Prot:Q8NEE8

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